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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. In frog liver, tyrosine aminotransferase is located mainly in cytoplasm. The enzyme is an anionic protein of mol. wt. 115 000 daltons, specific toward 2-oxoglutarate. The enzyme separates on ion-exchange chromatography into two active forms. 2. Administration of triiodotyronine in vivo induces the activity of the enzyme. Epinephrine and glucagon have no effect, and cAMP and insulin repress this activity by about 70%. 3. Triiodotyronine stimulates incorporation of [14C]leucine into protein, and the amount of the enzyme in the nacent polysome-bound protein is considerably increased.
Acta Biochim Pol 1975
PMID:Tyrosine aminotransferase in frog liver. 23 10

The investigations were carried out on 70 growing broiler chickens. The chickens were kept on a higher and the other ones on the lower level of nutrition. As a result of this the rate of growth was different in both groups. Glucagon had a strong calorigenic effect, reaching a peak 30 min after its injection. This effect of glucagon increased progressively with the growth and development of birds reaching a maximum in chickens aged about 7 weeks, and weighing approx. 1200 g. In the birds examined 2 hours after feeding the calorigenic effect of glucagon was most expressed in birds maintained on the low nutrition levels. The fall of RQ after glucagon injection may suggest that this hormone has a strong lipolytic action.
Acta Physiol Pol
PMID:Effect of glucagon on the metabolic rate in growing chicken. 49 46

The experiments were carried out on broiler chickens divided randomly into two groups differing in the feeding level and, consequently, in the rate of weight gain. Half the chickens in each group were given a single dose of glucagon 150 micrograms/kg, and the other half received a control solution of glycine buffer. The chickens were investigated 1--1.5 hour after feeding and after 18--20 hours of starvation using the technique of biopsy of the liver and the external pectoral muscle. In the biopsy specimens the glycogen level was determined immediately before glucagon administration and 30--60--90 minutes after the injection. It was found that glucagon injection caused either a rise or a fall in the glycogen level in the liver and that the trend of these changes depended on the feeding level of the chickens and on the duration of starvation of the birds before treatment. The glycogen level in the pectoral muscle of the chickens kept on the higher feeding level was observed to fall one hour after glucagon administration.
Acta Physiol Pol
PMID:Glucagon effect on glycogen content of chicken liver and muscles. 50 56

The investigations were carried out with a group of ten healthy men aged 20--26 years who were injected intravenously with glucagon in a single dose of 50 microgram per kg of body weight. Glucagon had no effect on myoinositol levels in the blood serum. It caused however, a significant decrease in the myoinositol discharge into urine and lowered the index of renal myoinositol clearance. The creatinine clearance index remained unchanged.
Acta Physiol Pol
PMID:The effect of glucagon on myoinositol levels in the blood serum and its excretion with urine. 74 10

The purpose of this work was to compare the hyperglycaemic effect of glucagon at rest and after prolonged exhausting exercise in dogs. The following doses of glucagon were administered in 10-minute i.v. infusions: 0.1, 0.5, 1.0 micgrogram-kg-1 min-1. Significant differences were demonstrated in the blood glucose level after glucagon administration in doses of 0.1 and 0-5 microgram-kg-1 min-1 at rest as well as after exercise, and glucagon-induced hyperglycaemia was always lower after exercise than at rest. Increasing of glucagon dose from 0.5 to 1.0 microgram-kg-1 min-1 was not followed by a similar increase of the hyperglycaemic response. In additional experiments glucagon was administered together with adrenaline using two combinations of doses: 0.1 micron g-kg-1min-1 of glucagon and 0.25 microgram-kg-1 min-1 of adrenaline or 1.0 microgram-kg-1 min-1 of glucogen and 1.0 microgram-kg-1 min-1 of adrenaline. The hyperglycaemic effects of glucagon and adrenaline were additive at rest and after exercise when low doses of both hormones were used. After prolonged exercise this additive effect was not found when the "saturating" doses of glucagon and adrenaline were used (1.0 microgram-kg-1 min-1). The results obtained suggest that the hyperglycaemic response to glucagon is decreased in dogs after prolonged excise. It seems that this can be partly explained by the changed reactivity of hepatic tissue to this horme after prolonged exercise.
Acta Physiol Pol
PMID:Hyperglycaemic effect of glucagon after prolonged exhausting exercise in dogs. 89 13

The secretion of insulin, glucagon and growth hormone was determined in the serum of patients with recently diagnosed juvenile-type diabetes (10 patients) during stimulation by intravenous infusion of L-arginine and was compared with the results found in a group of five healthy persons. The value of the insulinemia was significantly lower in the diabetics as compared with the healthy controls. Serum glucagon levels were higher in all diabetics when fasting and after L-arginine administration as compared with the controls but a significant difference was observed only at the peck of secretion (5 min after L-arginine administration). Growth hormone concentration was slightly higher in the diabetics after secretory stimulation than in the controls, particularly at the peak of secretion (30 and 45 min) but the difference was statistically no significant.
Pol Med Sci Hist Bull
PMID:Serum insulin, pancreatic glucagon and growth hormone levels in response to intravenous infusion of L-arginine in patients with recently detected juvenile diabetes. 95 42

The blood levels of glucagon, growth hormone and glucose were investigated in early (1st day) and late stages (3rd week) of myocardial infarction in 11 cases of severe and 6 cases of mild myocardial infarction. The results were related to those in 9 healthy controls. In severe myocardial infarction associated with complications the glucagon level was statistically significantly higher than in controls in the early as well as in the late stage of the disease. In mild myocardial infarction this was not observed. The growth hormone level was significantly higher than normal in patients with severe myocardial infarction in only a few cases and only in the early stage. The differences between both stages of infarction and between patients and controls were not significant. Blood glucose level in the early stage of severe myocardial infarction was higher than normal and statistically significantly higher than in the late stage. In view of the differences in blood glucose and glucogon levels during severe myocardial infarction it seems that hyperglycemia in early stages of the disease depends on the high catecholamines level in the blood and on the insulin: glucagon index and not on the absolute concentration of glucagon in the blood.
Pol Med Sci Hist Bull
PMID:Relationship between the blood glucagon, growth hormone and glucose levels in myocardial infarction. 99 57

Transient lowering of blood levels of free fatty acids (FFA) in man and experimental animals after ingestion of fat has been noted by many investigators and has been attributed to inhibition of mobilization of fatty acids from adipose tissue. Studies on lipid mobilizing activity in in vitro systems containing glucagon, insulin and anti-insulin anti-bodies as factors modifying lipolysis indicate that insulin is the basic inhibitor of lipolysis in the blood in the period immediately following feeding of animals. This observation has been confirmed by direct determinations of insulin levels by the radioimmunologic method. Experiments in which substances influencing activity of the autonomic nervous system were used show that ingestion of fats stimulates insulin secretion as a result of cholinergic stimulation. Studies on lipolytic activity of blood serum confirmed an essential role of lipoprotein lipase in the mechanism of deposition of triglycerides in adipose tissue during alimentary lipemia. The role of prostaglandins and intestinal hormones (enteroinsular axis) in the mechanism of regulation of FFA levels during alimentary lipemia is also discussed.
Ann Med Sect Pol Acad Sci 1975
PMID:Factors regulating blood levels of free fatty acids during alimentary lipemia. 118 13

In experiments with rabbits, glucagon prolonged the half-period of absorption of sodium iodide 125J in the left ventricular myocardium. Regitine prevented acceleration of the heart rate and impairment of capillary flow after glucagon. In healthy rabbits hippurate 125J clearance was unaffected by glucagon. After injury of the heart muscle by injection of silver nitrate solution into the left ventricular wall and depression of blood pressure, glucagon partly normalized renal clearance of hippurate 125J.
Mater Med Pol
PMID:The influence of glucagon on the blood supply of the heart and kidneys in rabbits. 121 13

The purpose of the presented study is a comparison of phytooestrogen--coumestrol and oestrone effects on carbohydrate metabolism in ovariectomized female rats and to examine the participation of pancreatic hormones in changes of this metabolism. Administration of coumestrol diminished muscle glycogen in investigated animals. There were no significant changes in insulin and glucagon blood level but decrease in the specific insulin binding in the muscle membranes was observed. It suggests that coumestrol effects the insulin receptor activity in this tissue and it could be a cause of glycogen deficiency.
Arch Vet Pol 1992
PMID:Effect of phytooestrogen--coumestrol and oestrone on some aspects of carbohydrate metabolism in ovariectomized female rats. 133 77


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