Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The complications caused by overweight, obesity and type 2 diabetes are one of the main problems that increase morbidity and mortality in developed countries. Hypothalamic metabolic sensors play an important role in the control of feeding and energy homeostasis. PAS kinase (PASK) is a nutrient sensor proposed as a regulator of glucose metabolism and cellular energy. The role of PASK might be similar to other known metabolic sensors, such as AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR). PASK-deficient mice resist diet-induced obesity. We have recently reported that AMPK and mTOR/S6K1 pathways are regulated in the ventromedial and lateral hypothalamus in response to nutritional states, being modulated by anorexigenic glucagon-like peptide-1 (GLP-1)/exendin-4 in lean and obese rats. We identified PASK in hypothalamic areas, and its expression was regulated under fasting/re-feeding conditions and modulated by exendin-4. Furthermore, PASK-deficient mice have an impaired activation response of AMPK and mTOR/S6K1 pathways. Thus, hypothalamic AMPK and S6K1 were highly activated under fasted/re-fed conditions. Additionally, in this study, we have observed that the exendin-4 regulatory effect in the activity of metabolic sensors was lost in PASK-deficient mice, and the anorexigenic properties of exendin-4 were significantly reduced, suggesting that PASK could be a mediator in the GLP-1 signalling pathway. Our data indicated that the PASK function could be critical for preserving the nutrient effect on AMPK and mTOR/S6K1 pathways and maintain the regulatory role of exendin-4 in food intake. Some of the antidiabetogenic effects of exendin-4 might be modulated through these processes.
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PMID:PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1. 2444 50

The ultrastructure of five epithelial cellular types is described. (1) Absorptive-storing cells possess a striated border and accumulate lipids and glycogen. They also contain an apical multivesicular complex and numerous membrane-bound PAS-positive granules of unknown significance. (2) Zymogenic cells contain numerous, large secretory granules. These cells also possess microvilli and accumulate lipid droplets. (3) Current-producing cells contain bundles of thick and thin myofilaments and extend from the basal lamina to the lumen. (4) Mucous cells display the characteristic features of such secretory cells. (5) In addition to these four cellular types, already observed under the light microscope by other authors, endocrine cells have also been identified by both light and electron microscope. They contain variable amounts of secretory granules of diverse sizes and electron densities. Immunocytochemical studies reveal the presence of cells immunoreactive to somatostatin, glucagon, and pancreatic polypeptide. Intraepithelial nerve fibers in contact with endocrine cells are also present. As far as we know, this appears to be the first description of enteroendocrine cells in the phylum Echinodermata.
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PMID:Microscopic study of the pyloric caeca of the starfish Marthasterias glacialis (Echinodermata): Finding of endocrine cells. 2986 90


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