Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Based upon the findings in over 1200 patients, technique, indication and validity of pharmacoradiology in examinations of esophagus, stomach, duodenum, small and large intestine are critically evaluated and summarized. Dosis, effects, side effects and contraindications of the mostly applied pharmaca (Buscopan, Pro-Banthine, Paspertin, Glucagon, Cholecystokinin and Caerulein) are listed. The value of pharmacoradiology of the gastrointestinal tract for clinical roentgenology is stressed.
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PMID:[Present status of pharmacoradiology of the gastrointestinal tract (author's transl)]. 101 16

Totally isolated whole canine stomachs perfused, ex vivo, with homologous blood of living supporting dogs were used for recording of myoelectrical mechanical activities. Drugs were administered directly into the arterial system of the isolated stomachs either as flash injections or as constant infusions. Flash injection of metoclopramide (Maxeran) led to the response activity (spiking) and associated mechanical response. Electrical control activity was also affected by Maxeran: the changes consisted of premature control activity and uncoupling. Similar reactions were observed after flash injections of methacholine, pentagastrin or electrical stimulation of the Latarjet nerve. These reactions were dose-dependent. Tetrodotoxin, atropine, hexamethonium and glucagon, when given as a constant infusion, did inhibit the action of Maxeran on myoelectrical and mechanical activities of the isolated stomach. Inhibition of the responses to Maxeran by atropine and tetrodotoxin implicates acetylcholine in the mediation of these responses. The ability of hexamethonium to diminish the response to Maxeran suggests that a locus of action may be at both pre- and post-ganglionic sites of the intramural plexus. Exact receptors of this action are not demonstrated by this study.
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PMID:Effect of metoclopramide on myoelectrical and mechanical activity of the isolated canine stomach perfused extracorporeally. 122 37