Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UNIPROT:P01275 (
glucagon
)
26,492
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Menadione
and NH4Cl were reported to lower the islet content of reduced pyridine nucleotides. They were used to investigate the possible significance of NAD(P)H in the regulation of
glucagon
release by glucose and arginine.
Menadione
(10-25 mumol/l) enhanced arginine-stimulated
glucagon
release at a low glucose concentration (3.3 mmol/l), but failed both to affect
glucagon
secretion in the sole presence of glucose (3.3 mmol/l) and to suppress the inhibitory action of glucose 11.1 mmol/l upon
glucagon
output. In contrast to menadione, NH4Cl inhibited arginine-stimulated
glucagon
release at the low glucose concentration. The inhibitory action of glucose in high concentration upon
glucagon
release was not suppressed by NH4Cl. These findings do not permit to extrapolate to the A2-cell the concept that reduced pyridine nucleotides represent a major coupling factor in the nutritional regulation of hormonal release.
...
PMID:Evidence for a limited role of NAD(P)H in the nutritional regulation of glucagon release: studies with menadione and NH4Cl. 699 42
