Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The hypotonic effect of glucagon (2 mg) and propantheline bromide (Pro-Banthine, 30 mg) on the upper gastrointestinal tract was compared in a double-blind study in 12 healthy volunteers and 36 patients. The solvent solution for the two drugs was used as a placebo. Both drugs and placebo were administered intramuscularly. The time of onset of the hypotonic effect was similar for both drugs, with maximum effect achieved 10 min after injection. Effects of glucagon dissapeared rapidly after 30 min, while Pro-Banthine still retained 50% of its maximum effect 2 1/2 hr after injection. Side effects of Pro-banthine were related to the long duration of the hypotonic effect (4-6 hr). A significant placebo effect on the duodenal C loop was observed. Glucagon appears to be the drug of choice since its hypotonic and hypomotile effects on the gastrointestinal tract are comparable to propantheline bromide while having the advantage of shorter duration and practically no side effects.
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PMID:Double-blind evaluation of glucagon and propantheline bromide (pro-banthine) for hypotonic duodenography. 40

Immediate and satisfactory gastrointestinal hypotonia was induced in 48 patients with 5--10 mg of intravenous Pro-Banthine during radiographic examination; side-effects were minimal. If given intravenously in small doses, Pro-Banthine is a satisfactory alternative when glucagon is contraindicated or not available.
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PMID:The use of Pro-Banthine to induce gastrointestinal hypotonia. 63 6

This clinical double-blind study shows that glucagon (2 mg) is a valuable agent for hypotonic duodenography. Pro-Banthine (45 mg) is slightly more effective as a hypotonic agent, but there is no doubt that its use is associated with more side effects and subsequent patient discomfort; contraindications to its use are more commonly encountered in a general hospital population.
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PMID:Hypotonic duodenography with glucagon. A clinical comparison study. 76 62

Based upon the findings in over 1200 patients, technique, indication and validity of pharmacoradiology in examinations of esophagus, stomach, duodenum, small and large intestine are critically evaluated and summarized. Dosis, effects, side effects and contraindications of the mostly applied pharmaca (Buscopan, Pro-Banthine, Paspertin, Glucagon, Cholecystokinin and Caerulein) are listed. The value of pharmacoradiology of the gastrointestinal tract for clinical roentgenology is stressed.
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PMID:[Present status of pharmacoradiology of the gastrointestinal tract (author's transl)]. 101 16