Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01275 (
glucagon
)
26,492
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The physiological and pathophysiological regulation of
glucagon
secretion from pancreatic alpha cells remains a hotly debated topic. The mechanism(s) contributing to the glucose sensitivity of
glucagon
release and its impaired regulation in diabetes remain unclear. A paper in the current issue of Diabetologia by da Silva Xavier and colleagues (doi: 10.1007/s00125-010-2010-7 ) provides intriguing new insight into a metabolic sensing pathway mediated by the per-arnt-sim (PAS) domain kinase (
PASK
) that may contribute to both the paracrine and the intrinsic glucose regulation of alpha cells. Importantly, the authors show that
PASK
is decreased in islets from patients with type 2 diabetes, providing a potential mechanism for impaired suppression of
glucagon
by hyperglycaemia in this disease. Much work remains to be done to determine the exact role and mechanism of
PASK
in alpha and beta cells. Nevertheless, the present work introduces a new player in the metabolic regulation of
glucagon
secretion.
...
PMID:Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion. 2118 96
