Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have found intravenous glucagon useful in overcoming the spasm of the rectal stump that one sometimes encounters while performing transanal end-to-end anastomosis using the EEA stapling device.
Dis Colon Rectum 1979 Oct
PMID:Use of glucagon in conjunction with the end-to-end anastomosis (EEA) stapling device for low anterior anastomoses. 52 27

Resting anal sphincter pressure and rectoanal reflex were studied in six healthy volunteers after administration of placebo, glucagon, and glucagon 1-21. Glucagon resulted in a marked but short-lived early decrease in resting anal pressure, whereas the 1-21 fragment of the glucagon molecule had no effect. Further investigation of the possible hormonal/peptidergic regulation of anal sphincter function is necessary.
Dis Colon Rectum 1985 Apr
PMID:The effect of glucagon and glucagon 1-21 on anal sphincter function. 397 25

Spasm of the proximal sigmoid colon has been a major hindrance in the use of the EEA stapler in low anterior resections. Intravenous glucagon, by causing rapid relaxation and hypotonicity of the sigmoid colon, appears to help correct this problem and allows for a safer and more atraumatic anastomosis.
Dis Colon Rectum
PMID:Glucagon, a useful adjunct in anastomosis with a stapling device. 737 47