Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The MATRIX study consisted of a large population of older adults. In addition to those over the age of 65, this study included 131 patients > or =85 years old. Even though these adults were community-based, many of them had similar medical histories, comorbidities, use of multiple medications and urinary incontinence histories as those residing in long-term care settings. This study found OXY-TDS to be effective in improving quality of life in these older adults. In addition, there was a low incidence of adverse events, particularly anticholinergic events. Overall, this study supports the use of OXY-TDS in older adults-those residing in community and nursing facility settings. The next article in this series will present other results of the MATRIX study, including the changes in nocturia and pad use, as well as the effect of OXY-TDS in participants with prostate problems.
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PMID:The MATRIX study: evaluating the data in older adults. 1934 87

Overactive bladder (OAB), clinically defined as urinary urgency, with or without incontinence, generally accompanied by an increase in urinary frequency and nocturia, after any local disease or metabolic disorder that would explain these symptoms have been ruled out, is a highly prevalent condition that affects millions of men and women worldwide. Not only can the symptoms of OAB be very bothersome, but OAB can have significant detrimental effects on many aspects of individuals' lives, representing a particularly impactful health burden to quality of life and productivity. Besides a wide range of conservative treatments, the clinical efficacy of which remains an open issue, antimuscarinics are the mainstay of pharmacotherapy for this condition but anticholinergic troublesome side effects like dry mouth, and the patient's perception of lack of efficacy and poor adherence, are common reasons of abandonment of treatment. An alternative to oral administration treatment, with a lower incidence of dry mouth and other anticholinergic adverse effects, might be attractive to patients and a real treatment option for physicians. Delivery of oxybutynin directly through the skin with oxybutynin transdermal (OXY-TDS) avoids the first-pass hepatic metabolism that occurs with orally administered oxybutynin and prevents the appearance of anticholinergic adverse events. OXY-TDS being equally effective than oral treatment improves adherence, persistence, and patient satisfaction. The aim of this review is to focus on evidence available of the use of OXY-TDS in the management of patients with OAB, and to help clinicians in the challenges involved in the treatment options for patients with this condition.
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PMID:Insights into the Management of Overactive Bladder with Transdermal Oxybutynin: A Practical Review. 3288 26