Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors review 15 cases of acute oesophageal obstruction arising from food (meat) or mucilage (3 cases). Obstruction was usually observed in the lower third of the oesophagus whereas in cases with stenosis due to caustic agents (2 cases), or tuberculosis (1 case), the middle third was affected. The obstruction is mainly related to the presence of a dyskinesia with or without an associated hiatus hernia. A transient isolated spasm of the lower oesophageal sphincter was present in three cases (20%). Urgent radiological examinations are essential for diagnostic and therapeutic reasons. An intravenous injection of glucagon must be given systematically and the patency of the oesophagus checked immediately afterwards. One patient was found to have two perforations of the oesophagus at different levels and these were thought to be due to different reasons. That in the cervical region was caused by a swallowed bone, the other was the probable consequence of the fibroscopic examination.
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PMID:[Acute oesophageal obstruction from food or mucilage: a report on 15 cases (author's transl)]. 50 96

Endoscopic manometry of sphincter of Oddi (SO) and serum levels of gastrin, glucagon, and somatostatin were measured in patients with postcholecystectomy syndrome (n = 12), asymptomatic cholecystectomy patients (n = 6), and controlled subjects (n = 14). Pentagastrin-stimulated gastric acid secretion test was also performed in part of patients who had symptoms or no symptoms after the removal of gallbladder. The results showed that the patients of symptomatic group had hypertonic dyskinesia of SO as shown by deep and wide waves superimposed on high basal pressure plateau of SO. The symptomatic group also had a higher serum level of gastrin and a greater BAO than those of other two groups. No difference of serum levels of glucagon and somatostatin was found among these three groups. The hypertonic dyskinesia of SO and hypergastrinemia are possibly important factors in the pathogenesis of postcholecystectomy syndrome.
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PMID:[A study on motility of sphincter of Oddi in postcholecystectomy syndrome]. 191 67