Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The treatment of acute pancreatitis as currently practised in Austria was evaluated by means of a questionnaire mailed to all medical and surgical departments in Austrian hospitals. Fasting, analgesics and parenteral fluid therapy are applied routinely and proteinase inhibitors are used in nearly all hospitals. The efficacy of placing the pancreas at rest by withdrawal of oral fluids, nasogastric suction or antacids is variably assessed. Pharmacological inhibition of pancreatic secretion is achieved mainly by anticholinergics, whilst less often glucagon is prescribed. Antibiotic prophylaxis is widely applied. The main indications for surgery are complications and pre-existing biliary tract disease. These results are compared with the literature.
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PMID:[The treatment of acute pancreatitis in Austria: results of a questionnaire]. 39 Aug 91

Seventy patients admitted to Waikato Hospital between 1964-74 with acute pancreatitis have been reviewed. Biliary tract disease and alcohol are the most common aetiological agents. The disease is most common in middle age. Europeans and Polynesians have similar incidence rates. The diagnosis is frequently not made at admission and most admissions are in the afternoon or early evening. Radiology is helpful in the diagnosis although nonspecific. Abnormal biochemistry is discussed and related to mortality. Additional tests, serum catalase/methaemalbumin are promoted to assist in the diagnosis and indicating the severity of the disease. Glucagon and Trasylol are discussed as being beneficial in this disease and combination therapy is suggested. The role of surgery is discussed.
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PMID:Acute pancreatitis ten years experience in the Waikato district. 108 Dec 8

Seventy-one patients with a clinical diagnosis of painful biliary tract disease have been entered into a double-blind trial of glucagon. Twenty-eight were excluded as gallstones were not proved: of the remainder, 21 patients received glucagon and 22 placebo. Glucagon-treated patients were pain free 14.26 h (+/- 2.77 s.e.m.) after commencing treatment compared to 29.14 h (+/- 6.01 s.e.m.) for the placebo group (P less than 0.05). Tenderness in the right hypochondrium showed a significant improvement when assessed at 12 h (P less than 0.02) and 24 h (P less than 0.1) for those given glucagon. A significant difference in blood glucose levels was seen between the two groups (P less than 0.05). No serious side effects were observed. Glucagon relieves the pain and tenderness associated with painful biliary tract disease more effectively than conventional therapy.
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PMID:A trial of glucagon in the treatment of painful biliary tract disease. 675 55