Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
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Human Gene/Protein
beta-endorphin 10.6
calpain11 10.6
testis expressed 261 10.6
follicle-stimulating hormone alpha subunit 10.6
adrenocorticotropic hormone 9.8
POMC protein 9.8
inositol polyphosphate-5-phosphatase A 9.6
MTLRP 9.6
endozepine-related protein 9.6
attractin-like protein 9.6
pleckstrin homology domain interacting protein 9.6
LPH 9.4
Proopiomelanocortin 9.3
melanocortin 2 receptor 9.3
CRHR2 9.2
MSH receptor 9.2
proopiomelanocortin 9.0
CYP11B1 protein 9.0
MC5R 8.9
melanocortin-5 receptor 8.8
melanocortin receptor 8.8
MSH 8.8
CRHR1 8.8
ACTH receptor 8.8
UCN2 8.8
TPIT 8.8
NPP5 8.8
MC3 8.7
GRP-preferring bombesin receptor 8.6
FGD2 8.6
CGA protein 8.6
melanocortin 4 receptor 8.6
Met-enkephalin 8.5
MSH4 8.5
NPP2 8.5
NPP4 8.5
V1bR 8.4
RESP18 8.4
urocortin 3 8.3
receptor accessory protein 2 8.2
PRKAR1 8.2
ACTH 8.2
CRH 8.2
CRF-BP 8.2
melanocortin-4 receptor 8.2
dynorphin 8.1
MRAP2 8.1
stresscopin 8.1
USP48 8.1
leu5 8.0
corticotropin-releasing factor 8.0
OR37A 8.0
IL1R3 8.0
relaxin/insulin-like family peptide receptor 1 8.0
zymogen granule membrane glycoprotein 2 8.0
TSC22D2 8.0
NOC2 8.0
agouti 8.0
corticotropin-releasing factor receptor 2 8.0
CRFR1 7.9
OGF 7.9
Ucn III 7.9
TBX19 7.8
pannexin 2 7.8
PhLP 7.8
KIAA1267 7.8
MRAP 7.7
TPH2 protein 7.7
MC4R 7.7
prohormone convertase 7.6
MC1 7.6
prohormone convertase 2 7.6
phosphodiesterase 11A 7.6
GalNAc-4-ST2 7.6
somatostatin receptor type 5 7.6
NSCL-2 7.6
Acyl-CoA synthetase 4 7.6
Betaine homocysteine methyltransferase 7.6
proenkephalin 7.6
CRFR 7.5
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Disease
Labyrinthine vertigo 10.6
Inflammatory polyarthritis 10.6
Myocardial decompensation 10.6
AIMAH 10.1
Nodding spasm 9.6
Secondary adrenal insufficiency 9.3
endocrine or metabolic disease 9.0
Cyclical Cushing's syndrome 9.0
Ketotic hypoglycemia 9.0
Pituitary microadenoma 9.0
Childhood conduct disorder 9.0
Glucocorticoid-suppressible hyperaldosteronism 8.8
ACTH deficiency 8.6
Isolated ACTH deficiency 8.6
autoimmune inflammatory bowel disease 8.6
Adrenal necrosis 8.6
FGD2 8.6
ACTH-dependent Cushing's syndrome 8.4
Crib-biting 8.4
Gangliocytoma 8.2
swelling of the pituitary gland 8.2
goiter with thyrotoxicosis 8.2
Menopausal depression 8.2
ACTH-secreting pituitary adenoma 8.2
Cushing's disease 8.2
Late onset congenital adrenal hyperplasia 8.0
Ectopic ACTH syndrome 7.9
ENDOCRINE 7.8
Delayed menarche 7.8
MHS6 7.8
Atypical benign partial epilepsy 7.8
fulminant purpura 7.8
hypercortisolism 7.6
Cushing's ulcer 7.6
Solitary mastocytoma 7.6
adrenal disorder 7.6
hypercortisolemia 7.5
DSAP 7.5
Cushing's syndrome 7.5
Naffziger 7.4
Melancholic depression 7.4
Muehrcke's lines 7.2
Post-traumatic hypopituitarism 7.2
hypoadrenocorticism 7.1
hypsarhythmia 7.1
ACTH-producing pituitary tumor 7.1
pituitary hyperfunction 7.0
Iatrogenic Cushing's syndrome 7.0
pulmonary carcinoid tumor 6.9
adrenal insufficiency 6.9
FGD3 6.8
Posterior subcapsular cataract 6.8
Aromatase deficiency 6.8
Adrenal gland 6.7
Adrenal gland 6.7
Hypothalamic obesity 6.7
adrenal hyperplasia 6.7
adrenal adenoma 6.7
Premature pubarche 6.7
Autistic behavior 6.7
VVS 6.7
Addison's disease 6.6
postlaminectomy syndrome 6.6
Addison's disease 6.6
ARH 6.5
pituitary tumor 6.5
HPA 6.5
Worster-Drought syndrome 6.5
adrenalitis 6.5
melanoderma 6.5
Opsoclonus-myoclonus syndrome 6.4
ADH decreased 6.4
hypokalemic alkalosis 6.4
hypolipoproteinemia 6.3
anxious state 6.3
Frontal lobe epilepsy 6.2
adrenocortical cancer 6.2
Pituitary 6.2
Milwaukee shoulder 6.2
pituitary adenoma 6.1
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Symptom
scant menses 10.6
Cushingoid 8.1
Cushingoid 8.0
Paroxysmal hypertension 6.9
acute stress 6.0
Central pain 5.9
Labor pain 5.6
Premenstrual symptoms 5.5
weight problem 5.4
Rest tremor 4.8
mouth pain 4.7
female puberty 4.6
Ear swelling 4.6
analgesia 4.6
Circling 4.6
Cold intolerance 4.5
Inflammatory pain 4.3
dysosmia 4.1
anorexia 4.0
polydipsia 3.8
elevated mood 3.8
cardiovascular impairment 3.8
phosphatemia 3.8
leg edema 3.8
Spots 3.7
bewilderment 3.7
Visceral pain 3.7
polyuria 3.6
POA 3.5
masculinization 3.5
catatonia 3.5
hunger 3.4
Postoperative pain 3.3
Severe pain 3.3
despair 3.2
physical exhaustion 3.2
Physical findings 3.2
Deafferentation 3.2
limb pain 3.2
hypalgesia 3.1
hot flushes 3.1
adipsia 3.0
aphagia 3.0
Chronic pelvic pain 2.9
cachexia 2.9
giddiness 2.9
giddiness 2.9
hypersomnia 2.9
emaciation 2.8
hypothermia 2.8
lethargy 2.7
myoclonus 2.7
orofacial pain 2.7
acute pain 2.6
arm pain 2.6
Decreased activity 2.5
consciousness disturbance 2.5
acute low back pain 2.5
cancer pain 2.4
prostatism 2.4
visual hallucination 2.4
excessive sweating 2.4
decreased appetite 2.4
exhaustion 2.4
anosmia 2.3
dysesthesia 2.3
thirsty 2.2
drooling 2.2
flushing 2.2
pain 2.1
insomnia 2.1
hot flashes 2.1
hangover 2.1
Poor sleep 2.1
chronic back pain 2.0
mastalgia 2.0
bladder pain 2.0
bradykinesia 2.0
Depressive symptoms 1.9
Involuntary Movement 1.9
more...
Drug
Metharmon-F 9.6
3-Bromo-7-Nitroindazole 9.6
Acthar 9.2
hCRH 9.1
Leucomycin 9.0
Xerecept 9.0
Fluocortin butyl 9.0
D-Aspartic Acid 8.6
Cortrosyn 8.3
Cortrosyn 8.3
PT-141 7.7
Cloprednol 7.6
Surital 7.6
Itopride hydrochloride 7.6
Cetraxate hydrochloride 7.6
Bifemelane hydrochloride 7.6
Axokine 7.4
Phenamine 7.4
Dexamethasone palmitate 7.2
Gonadorelin 7.1
Typhoid vaccine 7.1
Erythromycin stearate 7.1
Adosterol 7.0
Naloxone HCl 6.9
Fluvoxamine maleate 6.8
Lixivaptan 6.6
Conivaptan 6.2
Leucin 6.2
Flesinoxan 6.2
Trilostane 6.1
DEX 6.1
Fluvoxamine maleate 6.0
Elcatonin 5.8
Trimipramine 5.8
Thymopentin 5.8
Adinazolam 5.8
Norleucine 5.7
Dexfenfluramine 5.6
Tryptophane 5.6
Metoclopramide hydrochloride 5.5
Pitressin 5.5
Pirprofen 5.5
Morphine sulfate 5.3
GHRP 5.2
Ortho Tri-Cyclen 5.2
FSH-beta 5.2
FSH-beta 5.1
Eszopiclone 5.1
Flunisolide 5.0
Penfluridol 4.9
FSH-beta 4.9
CTZ 4.8
Monosodium glutamate 4.8
PBZ 4.8
Alarin 4.7
Proglumide 4.6
PAPM/BP 4.6
OctreoScan 4.6
Flunixin 4.6
Primperan 4.6
GRF 4.5
Dextran sulfate sodium 4.5
Forskolin 4.5
Bexxar 4.4
Growth hormone 4.4
Parlodel 4.4
Narcan 4.4
Growth hormone 4.4
Sandostatin 4.3
Sandostatin 4.3
Calan 4.3
Kayexalate 4.3
Adderall 4.3
CPZ 4.3
Bricanyl 4.2
Ketoconazole 4.2
Lipitor 4.2
Prozac 4.2
ICI 4.1
Salmon calcitonin 4.1
more...
Enzyme
gamma-renin 9.6
pepsin B 7.1
proprotein convertase 2 6.8
kallikrein 10 6.8
peptidase E 6.8
carboxypeptidase E 6.7
nucleotide pyrophosphatase 6.7
N-acetylneuraminylgalactosylglucosylceramide 6.7
17-ketoreductase 6.6
chondro-4-sulfatase 6.4
protein methylase II 6.2
steroid 11beta-hydroxylase 6.2
chondroitin 4-sulfotransferase 6.1
cytochrome P-450scc 6.1
21-hydroxylase 5.7
steroid 17alpha-hydroxylase 5.7
corticosterone methyl oxidase 5.7
carboxypeptidase B 5.6
HPI 5.6
type III iodothyronine deiodinase 5.4
aspartyl aminopeptidase 5.3
protein L-isoaspartyl methyltransferase 5.3
dihydroxyacetone phosphate acyltransferase 5.2
phenylethanolamine N-methyltransferase 5.2
PAF acetyltransferase 5.2
phospholipid methyltransferase 4.9
20beta-hydroxysteroid dehydrogenase 4.9
tyrosinase 4.9
acylglycerol kinase 4.9
aminopeptidase B 4.8
GPH 4.8
p-nitrophenylphosphatase 4.7
nardilysin 4.6
GSase 4.6
dopamine beta-hydroxylase 4.6
adenylate cyclase 4.6
thimet oligopeptidase 4.5
11beta-hydroxysteroid dehydrogenase 4.5
7-dehydrocholesterol reductase 4.4
3beta-hydroxysteroid dehydrogenase 4.4
furin 4.4
lysophospholipase D 4.4
tyrosine hydroxylase 4.3
PAF acetyltransferase 4.3
proprotein convertase 4.3
cholesterol esterase 4.3
DCF 4.2
insulin-degrading enzyme 4.0
neurolysin 4.0
D-aspartate oxidase 4.0
PFI 4.0
neuropsin 3.9
PIP kinase 3.9
HSD 3.8
polyphosphatase 3.7
adrenodoxin reductase 3.7
LDT 3.7
estrogen sulfotransferase 3.6
phenol oxidase 3.6
sulfiredoxin 3.6
proline iminopeptidase 3.6
renin 3.6
acyl-CoA thioesterase 3.5
CD10 3.5
EC 3.6.1.1 3.5
tripeptidyl peptidase 3.4
estrogen sulfotransferase 3.4
PTPase 3.4
nucleotidase 3.4
STK 3.3
PRA 3.3
arylsulfatase 3.3
ATP diphosphohydrolase 3.3
glutamate decarboxylase 3.3
AMP-activated kinase 3.3
glycerophosphate acyltransferase 3.3
neuropsin 3.3
betaine-homocysteine methyltransferase 3.2
PCE 3.2
NAT 3.2
more...
Compound
C20H30N4O8 10.6
2,4-dichlorophenylalanine 10.6
N-Acetyl-beta-endorphin 10.6
C20H30N4O8 10.6
Corticotropin 10.5
alpha-MSH 10.5
NPP 10.0
Salmefamol 9.2
MIF-I 9.2
Diurex 9.0
Kaurenol 8.6
androst-4-ene-3,11,17-trione 8.6
3,4-dichlorophenylalanine 8.6
ACTH 8.4
3-fluorobenzonitrile 8.2
1-methyl-3,4-dihydroisoquinoline 8.0
Phenylquinone 8.0
2,3-pyrazinedicarboxylic acid 8.0
3,21-dihydroxypregnan-20-one 8.0
20-hydroxycholesterol 7.8
Mersalyl acid 7.8
Methionine enkephalin 7.5
Dynorphin 7.4
U 50488 7.3
Ethylketocyclazocine 7.3
2-iodobenzamide 7.2
L-365260 7.2
Isoguvacine 7.2
Nitrophenylphosphate 7.2
Tetrapentylammonium 7.1
Gonadorelin 7.1
Dopaquinone 7.1
Diazoaminobenzene 7.1
Naloxone 7.0
Cosyntropin 7.0
Levallorphan 7.0
Dihydromorphine 7.0
Bremazocine 7.0
Levorphanol 6.8
D-Phenylalanine 6.8
Metyrapone 6.8
Metyrapone 6.8
Diphenoxylate 6.8
Piperlonguminine 6.8
Interferon beta-1b 6.7
NBTGR 6.7
NBTGR 6.7
NBTGR 6.7
NBTGR 6.7
Ergocryptine 6.7
1-phenylvinyl 6.6
Erythrocin 6.6
1-phenylvinyl 6.6
Isoguvacine 6.5
DAMGO 6.4
Woodward's Reagent K 6.4
Endomorphin-1 6.3
Cortisol 6.3
Morphiceptin 6.2
2,5-pyrrolidinedione 6.2
Histidyl-proline diketopiperazine 6.2
Corticosterone 6.1
BSX 6.1
SQ 20009 6.1
BSX 6.1
1,5-isoquinolinediol 6.1
1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 6.1
Naltrexone 6.1
DEX 6.1
DHM 6.1
17alpha-hydroxypregnenolone 6.1
Normorphine 6.0
3-methylpiperidine 6.0
3-methylpiperidine 6.0
Diprenorphine 6.0
Leucine enkephalin 6.0
17-OHP 6.0
Psoralidin 5.9
C2H4O2 5.9
Kyotorphin 5.9
more...