Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
21,003 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
beta-endorphin 21003
ACTH 4023
adrenocorticotropic hormone 2752
Sep 1380
prolactin 1202
insulin 988
growth hormone 934
vasopressin 889
corticotropin-releasing factor 871
proopiomelanocortin 816
dynorphin 770
MSH 766
Mol 710
neuropeptide Y 669
somatostatin 644
substance P 544
CRH 526
opioid receptor 521
leptin 515
arginine vasopressin 501
oxytocin 496
Gen 397
cytokine 351
Met-enkephalin 341
AMP 331
glucagon 306
glucocorticoid receptor 303
adenylate cyclase 290
angiotensin II 285
polypeptide 281
renin 278
CRF 272
calcitonin 268
cholecystokinin 264
Met 259
neurotensin 258
CD105 256
LHRH 254
agouti 245
thyrotropin-releasing hormone 221
lipopolysaccharide 212
ART 208
GABA 200
tyrosine hydroxylase 199
follicle-stimulating hormone 189
melanocortin receptor 179
MC3 179
tyrosinase 177
Leu-enkephalin 171
HPA 169
ghrelin 168
tumor necrosis factor 164
urocortin 155
bombesin 153
IL-6 153
proenkephalin 151
FSH 150
PRL 150
Leu5 150
ACTH receptor 147
melanin-concentrating hormone 146
IL-1 144
gut 141
gastrin 140
c-fos 140
LPH 139
ATP 137
TRH 136
hormone receptor 130
thymus 129
peroxidase 129
vasoactive intestinal peptide 128
orexin 128
5-hydroxytryptamine 127
galanin 127
CSF 116
olfactory 115
glycoprotein 115
X-linked 112
leptin receptor 111
more...
Disease
tumor 836
depression 752
obesity 611
Cushing's syndrome 567
Cushing's disease 485
hypertension 356
cancer 330
melanoma 317
adenoma 307
diabetes 305
chronic renal failure 303
hypercortisolism 282
hypoglycemia 268
Pituitary 263
adrenal insufficiency 259
major depressive disorder 211
cold 195
pituitary adenoma 175
HPA 169
pituitary tumor 166
carcinoma 151
SEM 120
hyperphagia 116
carcinoid 110
psychological stress 108
epilepsy 100
hyperglycemia 98
alcoholism 95
metastases 95
Alzheimer's disease 92
Nelson 86
West 84
pertussis 84
Addison's disease 82
cholera 82
ACTH deficiency 82
congenital adrenal hyperplasia 80
ischemia 79
schizophrenia 78
hypopituitarism 77
Addison's disease 77
multiple sclerosis 76
arthritis 74
anxiety disorders 74
aggression 74
posttraumatic stress disorder 72
chronic pain 72
addiction 69
anorexia nervosa 69
stroke 69
sepsis 68
hypercortisolemia 65
adrenal hyperplasia 65
rheumatoid arthritis 64
sepsis 64
neuroblastoma 63
aldosteronism 63
pheochromocytoma 61
SDS 60
type 2 diabetes 59
hyperinsulinemia 57
hyperprolactinemia 57
acromegaly 57
adrenal adenoma 53
hypothyroidism 53
polycystic ovary syndrome 52
amenorrhea 52
uterus 50
social stress 48
asthma 48
essential hypertension 48
psychosis 47
Anterior 47
lung carcinoma 46
diabetes insipidus 46
Parkinson's disease 45
Evans 45
dehydration 45
osteoporosis 44
hyperandrogenism 44
more...
Symptom
pain 740
analgesia 444
anesthesia 242
acute stress 201
seizures 194
anorexia 147
fatigue 100
headache 89
hypothermia 77
starvation 53
weakness 47
exhaustion 46
vomiting 42
hunger 40
nausea 39
overweight 39
Cushingoid 38
Cushingoid 38
insomnia 30
cachexia 28
tremor 28
diarrhea 25
polyuria 25
angina 25
functional recovery 24
lethargy 24
Ill 22
polydipsia 21
masculinization 19
abdominal pain 19
flushing 19
hypercapnia 18
myoclonus 18
agitation 18
collapse 17
discomfort 17
acute pain 16
discomfort 15
sleepiness 15
nausea and vomiting 15
spasm 14
low back pain 14
dyspnea 12
dizziness 11
cancer pain 11
ataxia 11
despair 10
chest pain 9
syncope 9
myalgia 9
respiratory distress 8
dystonia 8
catatonia 8
back pain 8
hot flushes 7
Postoperative pain 7
vertigo 6
leg edema 6
bradykinesia 6
constipation 6
thinning 6
bone pain 5
emaciation 5
Depressive symptoms 5
hypotonia 5
anosmia 5
hypersomnia 5
cough 5
hepatomegaly 4
Spots 4
memory loss 4
hoarseness 4
POA 4
paresis 4
acidity 4
colic 4
decreased appetite 4
limb pain 4
chorea 4
apathy 4
more...
Drug
Dermatol 174
lysine 139
CSF 125
Gel 103
Nephron 69
ICI 60
MAP 58
IL-2 56
Asn 44
Angiotensin II 43
Growth hormone 41
DEX 41
Growth hormone 41
Ethanol 39
Forskolin 38
IFN-gamma 33
EE2 32
Portal 29
hCRH 29
Cardiovasc 29
Clonidine 25
caffeine 25
Glucagon 23
Histamine 16
Cortrosyn 15
GRF 15
nitroglycerin 15
Indomethacin 15
ascorbate 14
GHRP 14
Ketoconazole 13
Cortrosyn 13
vitamin E 12
Diurnal 12
CTX 12
L-tyrosine 11
Luteinizing 11
Nephron 10
Retinoic acid 10
Fraction 10
CDP 9
Captopril 9
Ringer's solution 9
Estrogens 9
PCP 9
CaCl2 9
CaCl2 9
CaCl2 9
ABC 9
Leaf 9
PCB 8
Prednisone 8
Pitressin 8
Atropine 8
ENT 8
Ouabain 8
Apomorphine 8
IFN-beta 8
PTH 8
G418 7
DDAVP 7
Domperidone 7
DDAVP 7
CoCl2 7
Monit 7
HCH 7
CoCl2 7
Biopolymers 7
9-THC 7
Asthma 7
ROS 6
CAM 6
Acthar 6
Sulpiride 6
NADH 6
Dial 6
DMI 6
Trilostane 5
TAT 5
Fragment 5
more...
Enzyme
adenylate cyclase 298
protein kinase 291
renin 278
tyrosine hydroxylase 195
tyrosinase 176
peroxidase 160
protein kinase C 152
mitogen-activated protein kinase 102
trypsin 102
phosphodiesterase 90
ERK 88
CD10 73
alkaline phosphatase 66
AMPK 64
ATPase 58
reverse transcriptase 53
acetylcholinesterase 48
phospholipase C 48
furin 44
luciferase 43
NO synthase 42
21-hydroxylase 41
collagenase 36
RNase 34
RNase 34
lipase 33
acid phosphatase 31
HSD 31
carboxypeptidase E 27
AMP-activated protein kinase 26
superoxide dismutase 26
cytochrome P-450scc 25
nucleotide pyrophosphatase 25
DCF 24
calcineurin 24
focal adhesion kinase 23
MAP 22
ACE 22
phospholipase A2 22
dopamine beta-hydroxylase 22
carboxypeptidase B 20
NOS 20
lactate dehydrogenase 19
11beta-hydroxysteroid dehydrogenase 19
choline acetyltransferase 19
ornithine decarboxylase 18
RNA polymerase 18
creatine kinase 18
guanylate cyclase 18
catalase 18
MEK 18
enolase 18
chymotrypsin 17
lipoxygenase 17
adenosine deaminase 16
adenosine deaminase 16
subtilisin 15
phenylethanolamine N-methyltransferase 15
monoamine oxidase 15
proprotein convertase 14
pepsin 14
glutamate decarboxylase 14
3beta-hydroxysteroid dehydrogenase 13
caspase-3 13
S1 nuclease 13
PDE 12
chloramphenicol acetyltransferase 12
cholinesterase 12
alcohol dehydrogenase 12
cholesterol esterase 12
ribonuclease 11
ribonuclease 11
PRA 11
p-nitrophenylphosphatase 11
hormone-sensitive lipase 11
phosphoenolpyruvate carboxykinase 11
HPI 10
phosphoenolpyruvate carboxykinase 10
lysozyme 10
phosphoenolpyruvate carboxykinase 10
more...
Compound
ACTH 4427
alpha-MSH 1469
Dec 1446
Clin 1071
glucose 696
cAMP 680
NPP 660
water 603
methionine 578
calcium 573
aldosterone 511
sodium 505
arginine 426
Corticotropin 422
Phe 413
tyrosine 404
DNA 399
leucine 375
AMP 354
noradrenaline 342
lysine 333
Naloxone 318
ethanol 317
5-HT 307
NH2 304
sulfate 301
Gly 292
Cortisol 291
potassium 247
Adrenal 223
TSH 217
glutamate 214
His 212
GABA 209
GABA 203
acetate 193
phosphate 184
oxygen 180
nitric oxide 177
TRH 171
Morphine 156
Dexamethasone 140
ATP 137
alanine 134
gamma-aminobutyric acid 128
salt 123
threonine 118
Corticosterone 91
Asp 87
tryptophan 83
Insulin 82
Substance P 81
DAMGO 80
tryptophan 79
tryptophan 79
tryptophan 79
GTP 79
Dopamine 77
TNF 73
acetic acid 73
Vasopressin 73
CO2 72
SDS 68
serine 66
HCl 64
ICI 60
Dynorphin 60
Norepinephrine 59
zinc 58
cGMP 58
hydroxyindoleacetic acid 58
Ile 57
silver 56
Angiotensin II 55
PGE2 54
iron 54
DHA 53
D-Ala 51
DSM 51
galactose 50
more...