Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
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Human Gene/Protein
follicle-stimulating hormone alpha subunit 10.6
calpain11 10.6
testis expressed 261 10.6
beta-endorphin 10.6
adrenocorticotropic hormone 9.8
POMC protein 9.8
MTLRP 9.6
inositol polyphosphate-5-phosphatase A 9.6
attractin-like protein 9.6
pleckstrin homology domain interacting protein 9.6
endozepine-related protein 9.6
LPH 9.4
Proopiomelanocortin 9.3
melanocortin 2 receptor 9.3
CRHR2 9.2
MSH receptor 9.2
proopiomelanocortin 9.0
CYP11B1 protein 9.0
MC5R 8.9
melanocortin-5 receptor 8.8
melanocortin receptor 8.8
MSH 8.8
CRHR1 8.8
ACTH receptor 8.8
TPIT 8.8
NPP5 8.8
UCN2 8.8
MC3 8.7
FGD2 8.6
CGA protein 8.6
GRP-preferring bombesin receptor 8.6
melanocortin 4 receptor 8.6
Met-enkephalin 8.5
MSH4 8.5
NPP2 8.5
NPP4 8.5
V1bR 8.4
RESP18 8.4
urocortin 3 8.3
receptor accessory protein 2 8.2
more...
Disease
Labyrinthine vertigo 10.6
Myocardial decompensation 10.6
Inflammatory polyarthritis 10.6
AIMAH 10.1
Nodding spasm 9.6
Secondary adrenal insufficiency 9.3
endocrine or metabolic disease 9.0
Ketotic hypoglycemia 9.0
Cyclical Cushing's syndrome 9.0
Pituitary microadenoma 9.0
Childhood conduct disorder 9.0
Glucocorticoid-suppressible hyperaldosteronism 8.8
ACTH deficiency 8.6
Adrenal necrosis 8.6
FGD2 8.6
autoimmune inflammatory bowel disease 8.6
Isolated ACTH deficiency 8.6
ACTH-dependent Cushing's syndrome 8.4
Crib-biting 8.4
swelling of the pituitary gland 8.2
Menopausal depression 8.2
goiter with thyrotoxicosis 8.2
Gangliocytoma 8.2
ACTH-secreting pituitary adenoma 8.2
Cushing's disease 8.2
Late onset congenital adrenal hyperplasia 8.0
Ectopic ACTH syndrome 7.9
Atypical benign partial epilepsy 7.8
MHS6 7.8
Delayed menarche 7.8
ENDOCRINE 7.8
fulminant purpura 7.8
hypercortisolism 7.6
Solitary mastocytoma 7.6
Cushing's ulcer 7.6
adrenal disorder 7.6
hypercortisolemia 7.5
DSAP 7.5
Cushing's syndrome 7.5
Melancholic depression 7.4
more...
Symptom
scant menses 10.6
Cushingoid 8.1
Cushingoid 8.0
Paroxysmal hypertension 6.9
acute stress 6.0
Central pain 5.9
Labor pain 5.6
Premenstrual symptoms 5.5
weight problem 5.4
Rest tremor 4.8
mouth pain 4.7
female puberty 4.6
Ear swelling 4.6
analgesia 4.6
Circling 4.6
Cold intolerance 4.5
Inflammatory pain 4.3
dysosmia 4.1
anorexia 4.0
polydipsia 3.8
elevated mood 3.8
cardiovascular impairment 3.8
phosphatemia 3.8
leg edema 3.8
Spots 3.7
bewilderment 3.7
Visceral pain 3.7
polyuria 3.6
POA 3.5
masculinization 3.5
catatonia 3.5
hunger 3.4
Postoperative pain 3.3
Severe pain 3.3
despair 3.2
physical exhaustion 3.2
Physical findings 3.2
Deafferentation 3.2
limb pain 3.2
hypalgesia 3.1
more...
Drug
Metharmon-F 9.6
3-Bromo-7-Nitroindazole 9.6
Acthar 9.2
hCRH 9.1
Fluocortin butyl 9.0
Leucomycin 9.0
Xerecept 9.0
D-Aspartic Acid 8.6
Cortrosyn 8.3
Cortrosyn 8.3
PT-141 7.7
Cloprednol 7.6
Surital 7.6
Bifemelane hydrochloride 7.6
Cetraxate hydrochloride 7.6
Itopride hydrochloride 7.6
Phenamine 7.4
Axokine 7.4
Dexamethasone palmitate 7.2
Erythromycin stearate 7.1
Typhoid vaccine 7.1
Gonadorelin 7.1
Adosterol 7.0
Naloxone HCl 6.9
Fluvoxamine maleate 6.8
Lixivaptan 6.6
Leucin 6.2
Conivaptan 6.2
Flesinoxan 6.2
Trilostane 6.1
DEX 6.1
Fluvoxamine maleate 6.0
Trimipramine 5.8
Elcatonin 5.8
Thymopentin 5.8
Adinazolam 5.8
Norleucine 5.7
Dexfenfluramine 5.6
Tryptophane 5.6
Metoclopramide hydrochloride 5.5
more...
Enzyme
gamma-renin 9.6
pepsin B 7.1
peptidase E 6.8
proprotein convertase 2 6.8
kallikrein 10 6.8
carboxypeptidase E 6.7
nucleotide pyrophosphatase 6.7
N-acetylneuraminylgalactosylglucosylceramide 6.7
17-ketoreductase 6.6
chondro-4-sulfatase 6.4
protein methylase II 6.2
steroid 11beta-hydroxylase 6.2
chondroitin 4-sulfotransferase 6.1
cytochrome P-450scc 6.1
21-hydroxylase 5.7
steroid 17alpha-hydroxylase 5.7
corticosterone methyl oxidase 5.7
carboxypeptidase B 5.6
HPI 5.6
type III iodothyronine deiodinase 5.4
aspartyl aminopeptidase 5.3
protein L-isoaspartyl methyltransferase 5.3
dihydroxyacetone phosphate acyltransferase 5.2
phenylethanolamine N-methyltransferase 5.2
PAF acetyltransferase 5.2
phospholipid methyltransferase 4.9
20beta-hydroxysteroid dehydrogenase 4.9
tyrosinase 4.9
acylglycerol kinase 4.9
aminopeptidase B 4.8
GPH 4.8
p-nitrophenylphosphatase 4.7
nardilysin 4.6
GSase 4.6
dopamine beta-hydroxylase 4.6
adenylate cyclase 4.6
thimet oligopeptidase 4.5
11beta-hydroxysteroid dehydrogenase 4.5
7-dehydrocholesterol reductase 4.4
3beta-hydroxysteroid dehydrogenase 4.4
more...
Compound
2,4-dichlorophenylalanine 10.6
C20H30N4O8 10.6
N-Acetyl-beta-endorphin 10.6
C20H30N4O8 10.6
Corticotropin 10.5
alpha-MSH 10.5
NPP 10.0
Salmefamol 9.2
MIF-I 9.2
Diurex 9.0
androst-4-ene-3,11,17-trione 8.6
Kaurenol 8.6
3,4-dichlorophenylalanine 8.6
ACTH 8.4
3-fluorobenzonitrile 8.2
1-methyl-3,4-dihydroisoquinoline 8.0
3,21-dihydroxypregnan-20-one 8.0
Phenylquinone 8.0
2,3-pyrazinedicarboxylic acid 8.0
Mersalyl acid 7.8
20-hydroxycholesterol 7.8
Methionine enkephalin 7.5
Dynorphin 7.4
U 50488 7.3
Ethylketocyclazocine 7.3
2-iodobenzamide 7.2
L-365260 7.2
Isoguvacine 7.2
Nitrophenylphosphate 7.2
Tetrapentylammonium 7.1
Dopaquinone 7.1
Gonadorelin 7.1
Diazoaminobenzene 7.1
Naloxone 7.0
Cosyntropin 7.0
Levallorphan 7.0
Dihydromorphine 7.0
Bremazocine 7.0
Levorphanol 6.8
D-Phenylalanine 6.8
more...