Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
beta-endorphin 21003
ACTH 4023
adrenocorticotropic hormone 2752
Sep 1380
prolactin 1202
insulin 988
growth hormone 934
vasopressin 889
corticotropin-releasing factor 871
proopiomelanocortin 816
dynorphin 770
MSH 766
Mol 710
neuropeptide Y 669
somatostatin 644
substance P 544
CRH 526
opioid receptor 521
leptin 515
arginine vasopressin 501
oxytocin 496
Gen 397
cytokine 351
Met-enkephalin 341
AMP 331
glucagon 306
glucocorticoid receptor 303
adenylate cyclase 290
angiotensin II 285
polypeptide 281
renin 278
CRF 272
calcitonin 268
cholecystokinin 264
Met 259
neurotensin 258
CD105 256
LHRH 254
agouti 245
thyrotropin-releasing hormone 221
lipopolysaccharide 212
ART 208
GABA 200
tyrosine hydroxylase 199
follicle-stimulating hormone 189
melanocortin receptor 179
MC3 179
tyrosinase 177
Leu-enkephalin 171
HPA 169
ghrelin 168
tumor necrosis factor 164
urocortin 155
IL-6 153
bombesin 153
proenkephalin 151
FSH 150
Leu5 150
PRL 150
ACTH receptor 147
melanin-concentrating hormone 146
IL-1 144
gut 141
c-fos 140
gastrin 140
LPH 139
ATP 137
TRH 136
hormone receptor 130
thymus 129
peroxidase 129
vasoactive intestinal peptide 128
orexin 128
galanin 127
5-hydroxytryptamine 127
CSF 116
glycoprotein 115
olfactory 115
X-linked 112
leptin receptor 111
Leptin 107
melanocortin-4 receptor 103
IL-1 beta 102
AVP 101
interleukin-6 100
melanocortin 4 receptor 99
endoplasmic reticulum 96
cocaine- and amphetamine-regulated transcript 96
brain-derived neurotrophic factor 95
NPY 94
cage 88
adenylyl cyclase 88
phosphodiesterase 88
chorionic gonadotropin 87
mineralocorticoid receptor 86
ferredoxin 86
rat) 83
thyroid stimulating hormone 83
Ang II 82
vasoactive intestinal peptide (VIP) 80
Neuropeptide Y 80
MC4R 79
GTP 79
nitric oxide synthase 78
Proopiomelanocortin 76
GHRH 76
She 73
TNF 73
Nle 72
LPS 70
thyroid hormone 70
MC5R 69
TNF-alpha 69
MSH receptor 69
pancreatic polypeptide 69
CRHR1 67
prodynorphin 66
CCK 66
alkaline phosphatase 64
PC2 63
melanocortin 2 receptor 62
C-terminal peptide 62
axonal 62
calmodulin 61
CA1 61
precursor protein 61
SDS 60
Prolactin 60
serum albumin 59
Pol 59
MRI 59
MC1R 58
MC1 58
VIP 57
atrial natriuretic peptide 57
mast cell 57
SRIF 57
IL-10 56
interferon 56
IL-2 56
5-HT1A 56
cAMP-dependent protein kinase 56
ATPase 55
secretin 55
phosphatase 55
CLIP 54
bradykinin 52
atrial natriuretic factor 51
mu opioid receptor 50
interleukin-2 50
neuron-specific enolase 50
cyclooxygenase 49
membrane-bound 48
lymphoid 47
Growth hormone 46
CO2 46
SRP 45
Ghrelin 45
PC1 45
peptidase 45
more...
Disease
tumor 836
depression 752
obesity 611
Cushing's syndrome 567
Cushing's disease 485
hypertension 356
cancer 330
melanoma 317
adenoma 307
diabetes 305
chronic renal failure 303
hypercortisolism 282
hypoglycemia 268
Pituitary 263
adrenal insufficiency 259
major depressive disorder 211
cold 195
pituitary adenoma 175
HPA 169
pituitary tumor 166
carcinoma 151
SEM 120
hyperphagia 116
carcinoid 110
psychological stress 108
epilepsy 100
hyperglycemia 98
metastases 95
alcoholism 95
Alzheimer's disease 92
Nelson 86
pertussis 84
West 84
ACTH deficiency 82
cholera 82
Addison's disease 82
congenital adrenal hyperplasia 80
ischemia 79
schizophrenia 78
hypopituitarism 77
Addison's disease 77
multiple sclerosis 76
aggression 74
anxiety disorders 74
arthritis 74
chronic pain 72
posttraumatic stress disorder 72
addiction 69
anorexia nervosa 69
stroke 69
sepsis 68
hypercortisolemia 65
adrenal hyperplasia 65
sepsis 64
rheumatoid arthritis 64
aldosteronism 63
neuroblastoma 63
pheochromocytoma 61
SDS 60
type 2 diabetes 59
hyperinsulinemia 57
acromegaly 57
hyperprolactinemia 57
hypothyroidism 53
adrenal adenoma 53
amenorrhea 52
polycystic ovary syndrome 52
uterus 50
essential hypertension 48
social stress 48
asthma 48
psychosis 47
Anterior 47
lung carcinoma 46
diabetes insipidus 46
dehydration 45
Parkinson's disease 45
Evans 45
hyperandrogenism 44
osteoporosis 44
tumorigenesis 43
lung cancer 43
metabolic syndrome 42
varices 42
emotional stress 42
malnutrition 41
fits 41
mental illness 41
myocardial ischemia 41
21-hydroxylase deficiency 40
adenocarcinoma 38
immunodeficiency 37
AIDS 37
panic disorder 37
dementia 36
adrenal mass 36
neuroendocrine tumor 36
tumor growth 36
HIV 35
migraine 35
Steroids 34
catalepsy 34
heart failure 34
infertility 34
medullary thyroid carcinoma 33
atopic dermatitis 33
plaque 32
glucose intolerance 32
breast cancer 31
irritable bowel syndrome 31
skin cancer 31
ACTH-dependent Cushing's syndrome 29
cerebral ischemia 29
glioma 28
disinhibition 28
encephalopathy 28
wasting 28
cognitive impairment 27
autoimmune disease 27
prolactinoma 26
emotionality 26
aggressiveness 26
drug addiction 25
cardiovascular disease 25
leukemia 25
affective disorder 25
small cell lung cancer 25
multiple endocrine neoplasia 25
coronary artery disease 25
suicide 24
acne 24
growth hormone deficiency 24
osteoarthritis 23
congestive heart failure 23
panhypopituitarism 23
DBA 23
Huntington's disease 23
achalasia 22
mole 22
autism 22
fibromyalgia 22
carcinogenesis 21
prostate cancer 21
clinical depression 21
physical dependence 21
proteinuria 21
hormone deficiency 21
atherosclerosis 21
hypogonadism 21
type 1 diabetes 21
adrenocortical carcinoma 21
precocious puberty 20
major depressive episode 20
hyperthyroidism 20
hypoadrenocorticism 20
infectious diseases 19
neuroendocrine carcinoma 19
nephrotic syndrome 19
inflammatory bowel disease 19
alcohol abuse 19
more...
Symptom
pain 740
analgesia 444
anesthesia 242
acute stress 201
seizures 194
anorexia 147
fatigue 100
headache 89
hypothermia 77
starvation 53
weakness 47
exhaustion 46
vomiting 42
hunger 40
nausea 39
overweight 39
Cushingoid 38
Cushingoid 38
insomnia 30
tremor 28
cachexia 28
diarrhea 25
polyuria 25
angina 25
functional recovery 24
lethargy 24
Ill 22
polydipsia 21
masculinization 19
abdominal pain 19
flushing 19
agitation 18
myoclonus 18
hypercapnia 18
discomfort 17
collapse 17
acute pain 16
discomfort 15
nausea and vomiting 15
sleepiness 15
low back pain 14
spasm 14
dyspnea 12
cancer pain 11
dizziness 11
ataxia 11
despair 10
syncope 9
myalgia 9
chest pain 9
respiratory distress 8
dystonia 8
back pain 8
catatonia 8
hot flushes 7
Postoperative pain 7
vertigo 6
thinning 6
bradykinesia 6
constipation 6
leg edema 6
anosmia 5
emaciation 5
hypotonia 5
Depressive symptoms 5
hypersomnia 5
bone pain 5
cough 5
hoarseness 4
hepatomegaly 4
POA 4
apathy 4
twitching 4
orofacial pain 4
decreased appetite 4
chorea 4
Spots 4
limb pain 4
acidity 4
paresis 4
memory loss 4
colic 4
tachypnea 3
stridor 3
erythema 3
hot flashes 3
Sedation 3
dysesthesia 3
asthenia 3
alexithymia 3
consciousness disturbance 3
arthralgia 3
flank pain 3
oliguria 3
regurgitation 3
paresthesia 3
pelvic pain 3
hyperoxia 3
abdominal discomfort 3
heartburn 3
sneezing 3
bloating 3
acute abdominal pain 3
Central pain 2
blurred vision 2
wheezing 2
distraction 2
hypoproteinemia 2
drooling 2
Decreased activity 2
HSA 2
muscle rigidity 2
spasticity 2
facial pain 2
female puberty 2
Physical findings 2
arm pain 2
ophthalmoplegia 2
Neuropathic pain 2
dry skin 2
pallor 2
menopausal symptoms 2
sciatica 2
chronic back pain 2
excessive sweating 2
cerebellar ataxia 2
splenomegaly 2
dental pain 1
acute low back pain 1
nasal discharge 1
Visceral pain 1
hip pain 1
visual hallucination 1
syncopal episodes 1
Paroxysmal hypertension 1
scant menses 1
Inflammatory pain 1
chills 1
Poor sleep 1
sinus pressure 1
Catch 1
hypalgesia 1
physical exhaustion 1
forgetfulness 1
dysosmia 1
bitter taste 1
Involuntary Movement 1
bewilderment 1
shortness of breath 1
eds 1
Fluctuation 1
hopelessness 1
CSR 1
mastalgia 1
incoordination 1
skin damage 1
paraparesis 1
elevated mood 1
dysuria 1
Rest tremor 1
more...
Drug
Dermatol 174
lysine 139
CSF 125
Gel 103
Nephron 69
ICI 60
MAP 58
IL-2 56
Asn 44
Angiotensin II 43
Growth hormone 41
DEX 41
Growth hormone 41
Ethanol 39
Forskolin 38
IFN-gamma 33
EE2 32
Cardiovasc 29
hCRH 29
Portal 29
caffeine 25
Clonidine 25
Glucagon 23
Histamine 16
nitroglycerin 15
Indomethacin 15
GRF 15
Cortrosyn 15
GHRP 14
ascorbate 14
Ketoconazole 13
Cortrosyn 13
CTX 12
Diurnal 12
vitamin E 12
L-tyrosine 11
Luteinizing 11
Fraction 10
Nephron 10
Retinoic acid 10
Captopril 9
Ringer's solution 9
PCP 9
CaCl2 9
CaCl2 9
Estrogens 9
ABC 9
CDP 9
Leaf 9
CaCl2 9
PTH 8
Prednisone 8
Atropine 8
Apomorphine 8
PCB 8
ENT 8
Pitressin 8
Ouabain 8
IFN-beta 8
Domperidone 7
9-THC 7
G418 7
CoCl2 7
Monit 7
DDAVP 7
HCH 7
Biopolymers 7
DDAVP 7
CoCl2 7
Asthma 7
DMI 6
CAM 6
Dial 6
Sulpiride 6
NADH 6
ROS 6
Acthar 6
Phentolamine 5
Paraffin 5
Fragment 5
p75 5
TAT 5
DHT 5
Aprotinin 5
DNase I 5
Trilostane 5
Monensin 5
pyridoxal phosphate 5
Alanine 5
DHT 5
Bifidobacterium 5
Theophylline 5
Scopolamine 4
Spectrum 4
Raloxifene 4
ROC 4
Prednisolone 4
Propofol 4
HCG 4
Secretin 4
Sandostatin 4
Allergen 4
EPI 4
CPZ 4
Sandostatin 4
Vitamin E 4
Dexfenfluramine 4
Monosodium glutamate 3
IL-1ra 3
Fentanyl 3
Silica 3
Finasteride 3
FSH-beta 3
Simvastatin 3
ALA 3
ZnCl2 3
FSH-beta 3
Frontal 3
ETA 3
ZnCl2 3
Prozac 3
Kenyan 3
CTX 3
CCL 3
Sodium nitroprusside 3
Diphenhydramine 3
PT-141 3
Adenosine deaminase 3
FSH-beta 3
CED 3
Thymopentin 3
Morphine sulfate 3
G-CSF 3
CTX 3
Heme 3
ID2 3
Vitamin A 3
Spectrum 2
Agomelatine 2
Pramipexole 2
Sodium valproate 2
DBS 2
Parlodel 2
Nitric Oxide 2
Reserpine 2
Limonene 2
Lovastatin 2
Codeine 2
CTC 2
FAD 2
Flesinoxan 2
Kainic acid 2
Pronase 2
Mezlocillin 2
Flunitrazepam 2
citric acid 2
Gastro 2
Ritanserin 2
DFP 2
Rimonabant 2
more...
Enzyme
adenylate cyclase 298
protein kinase 291
renin 278
tyrosine hydroxylase 195
tyrosinase 176
peroxidase 160
protein kinase C 152
mitogen-activated protein kinase 102
trypsin 102
phosphodiesterase 90
ERK 88
CD10 73
alkaline phosphatase 66
AMPK 64
ATPase 58
reverse transcriptase 53
acetylcholinesterase 48
phospholipase C 48
furin 44
luciferase 43
NO synthase 42
21-hydroxylase 41
collagenase 36
RNase 34
RNase 34
lipase 33
HSD 31
acid phosphatase 31
carboxypeptidase E 27
superoxide dismutase 26
AMP-activated protein kinase 26
cytochrome P-450scc 25
nucleotide pyrophosphatase 25
calcineurin 24
DCF 24
focal adhesion kinase 23
MAP 22
phospholipase A2 22
dopamine beta-hydroxylase 22
ACE 22
NOS 20
carboxypeptidase B 20
lactate dehydrogenase 19
11beta-hydroxysteroid dehydrogenase 19
choline acetyltransferase 19
guanylate cyclase 18
ornithine decarboxylase 18
RNA polymerase 18
catalase 18
MEK 18
enolase 18
creatine kinase 18
lipoxygenase 17
chymotrypsin 17
adenosine deaminase 16
adenosine deaminase 16
subtilisin 15
phenylethanolamine N-methyltransferase 15
monoamine oxidase 15
pepsin 14
proprotein convertase 14
glutamate decarboxylase 14
caspase-3 13
S1 nuclease 13
3beta-hydroxysteroid dehydrogenase 13
cholinesterase 12
alcohol dehydrogenase 12
cholesterol esterase 12
PDE 12
chloramphenicol acetyltransferase 12
ribonuclease 11
ribonuclease 11
PRA 11
phosphoenolpyruvate carboxykinase 11
hormone-sensitive lipase 11
p-nitrophenylphosphatase 11
phosphoenolpyruvate carboxykinase 10
ADH 10
aspartate aminotransferase 10
phytase 10
phytase 10
phosphoenolpyruvate carboxykinase 10
phosphatidylinositol 3-kinase 10
lysozyme 10
CD13 10
HPI 10
5'-nucleotidase 9
thymidine kinase 9
glutathione S-transferase 9
PAM 9
lipoprotein lipase 9
beta-galactosidase 9
PCP 9
alanine aminotransferase 9
thrombin 9
AMPK 8
NADPH-diaphorase 8
tryptase 8
PCE 8
transcriptase 8
ACS 8
histidine decarboxylase 8
arylsulfatase 8
kallikrein 8
CPT 8
insulin-degrading enzyme 8
acetyl-CoA carboxylase 8
aldehyde dehydrogenase 7
phenol oxidase 7
nucleotidase 7
glucokinase 7
endonuclease 7
PTPase 7
phosphorylase 6
glyceraldehyde-3-phosphate dehydrogenase 6
diaphorase 6
thermolysin 6
NQO1 6
PARP 6
P-glycoprotein 6
tryptophan hydroxylase 6
heme oxygenase 6
alpha-glucosidase 6
TAT 6
leucine aminopeptidase 6
succinate dehydrogenase 6
proteasome 6
GSK 5
adrenodoxin reductase 5
acyl-CoA synthetase 5
prostate-specific antigen 5
carbonic anhydrase 5
3-hydroxy-3-methylglutaryl coenzyme A reductase 5
DNase 5
ceruloplasmin 5
gamma-glutamyl transpeptidase 5
transglutaminase 5
hyaluronidase 5
acyl-CoA synthetase 5
sulfatase 5
AST 5
thyroid peroxidase 5
diaphorase 5
glutathione peroxidase 5
kinesin 5
glucose oxidase 5
MIP 5
estrogen sulfotransferase 4
phosphoinositide 3-kinase 4
urokinase-type plasminogen activator 4
cytochrome oxidase 4
sucrase 4
lactase 4
glyceraldehyde-3-phosphate dehydrogenase 4
diacylglycerol acyltransferase 4
endoglycosidase H 4
5alpha-reductase 4
prolyl endopeptidase 4
NAT 4
neuraminidase 4
more...
Compound
ACTH 4427
alpha-MSH 1469
Dec 1446
Clin 1071
glucose 696
cAMP 680
NPP 660
water 603
methionine 578
calcium 573
aldosterone 511
sodium 505
arginine 426
Corticotropin 422
Phe 413
tyrosine 404
DNA 399
leucine 375
AMP 354
noradrenaline 342
lysine 333
Naloxone 318
ethanol 317
5-HT 307
NH2 304
sulfate 301
Gly 292
Cortisol 291
potassium 247
Adrenal 223
TSH 217
glutamate 214
His 212
GABA 209
GABA 203
acetate 193
phosphate 184
oxygen 180
nitric oxide 177
TRH 171
Morphine 156
Dexamethasone 140
ATP 137
alanine 134
gamma-aminobutyric acid 128
salt 123
threonine 118
Corticosterone 91
Asp 87
tryptophan 83
Insulin 82
Substance P 81
DAMGO 80
GTP 79
tryptophan 79
tryptophan 79
tryptophan 79
Dopamine 77
acetic acid 73
Vasopressin 73
TNF 73
CO2 72
SDS 68
serine 66
HCl 64
ICI 60
Dynorphin 60
Norepinephrine 59
hydroxyindoleacetic acid 58
cGMP 58
zinc 58
Ile 57
silver 56
Angiotensin II 55
iron 54
PGE2 54
DHA 53
D-Ala 51
DSM 51
hydrogen 50
galactose 50
creatinine 48
urea 48
cysteine 48
Oxytocin 47
glycerol 47
glutamine 47
Naltrexone 46
ADP 45
ADP 44
glutamic acid 44
ADP 44
nitrogen 43
5-hydroxytryptophan 42
Mg2+ 42
COS 42
proline 41
prostaglandin E1 41
iodine 41
L-DOPA 41
DEX 40
Forskolin 38
Cocaine 38
Progesterone 38
methanol 36
ammonium 35
Estradiol 35
bromide 35
Thyroid 34
aspartic acid 34
Melatonin 34
acetone 34
17-OHP 33
EDTA 32
retinoic acid 32
EDTA 32
isoleucine 31
Neuronal 31
isoleucine 31
PAS 31
Estrogen 31
cadmium 30
Testosterone 30
valine 30
Testosterone 30
NMDA 29
adenylate 29
Neurotensin 29
Nicotine 28
Melanin 28
Ang II 28
Cardiol 28
Salt 28
5-HIAA 27
Estrogen 27
Metyrapone 27
Metyrapone 27
acetonitrile 26
PEG 26
caffeine 25
DBA 24
cobalt 24
Haloperidol 24
Haloperidol 24
GDP 23
Glucagon 23
Calcitonin 23
MAP 22
NIDA 22
DBA 22
Methionine 22
DBA 22
phosphorus 21
PGE 21
aldehyde 20
Triton X-100 20
formaldehyde 20
copper 20
PMA 20
GMP 20
more...