Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The hypothalamus, limbic system, and brainstem play an important role in the regulation of instinctive behavior. Many kinds of hypothalamic neuropeptides, such as orexin, ghrelin, neuropeptide Y, melanin-concentrating hormone, pituitary adenylate cyclase-activating polypeptide, corticotropin-releasing hormone, and diazepam-binding inhibitor-derived peptides, including the octadecaneuropeptide, have been implicated in the regulation of appetite and energy homeostasis in various models, including rodents and goldfish. Several of these neuropeptides also influence locomotor or psychomotor activity in rats and mice. The aim of this paper is to review the current knowledge on the psychophysiological effects of neuropeptides involved in the regulation of food intake in fish, and to examine their significance from a comparative point of view.
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PMID:Behavioral effect of neuropeptides related to feeding regulation in fish. 2138 9

Cerebrospinal fluid (CSF) neurohumors reflect central nervous system physiology in a way that peripheral indices can not. We reviewed clinical studies of CSF biogenic amines and neurohormones in alcohol misusers during various stages of withdrawal or abstinence and found them difficult to compare because of highly variable experimental methods, reliance on single time collections (lumbar punctures) that fail to control for potential stress-induced effects of the procedure, lack of control for tobacco use, and a paucity of non-alcoholmisusing controls. However, taken together, the data thus far show that a variety of neuroactive substances are reduced in concentration in the CSF of some alcohol misusers. Low CSF levels of corticotropinreleasing hormone, beta-endorphin, norepinephrine, diazepam-binding inhibitor, 5-hydroxyindoleacetic acid and somatostatin have all been reported. Whether the decreased CSF levels of these neurohormones and neurotransmitters are a cause or consequence of alcoholism has not been determined. In fact, further studies using serial or continuous CSF sampling techniques with homogeneous, better-characterized patients and normal volunteers are still needed to establish the precise CSF neurochemical abnormalities in alcohol misusers.
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PMID:Cerebrospinal fluid neuroendocrinology of alcohol misusers. 2673 45


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