Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several analogues of Met-enkephalin and beta-endorphin were tested for their analgesic properties after systemic injection. The latencies of mice to flick their tails away from a source of heat revealed that analogues of the opiate peptides can cause analgesia when injected by this route. In particular, compounds specifically designed to be more lipophilic or to possess additional binding sites were shown to be potent analgesic after peripheral administration.
Pharmacol Biochem Behav 1979 Dec
PMID:Analgesia after peripheral administration of enkephalin and endorphin analogues. 53 61

Actions of beta-MSH and of melatonin on the recovery cycle of single spinal neurones were studied in the decerebrate-spinal cat. beta-MSH facilitated the rate of post-excitation recovery of alpha-motoneurones and some internuncial neurones, and melatonin inhibited the rate of post-excitation recovery. These observations provide additional evidence that beta-MSH functions in the nervous system as a modulator, and may help explain actions of beta-MSH in modifying acquisition of conditioned avoidance responses as well as its interaction with drugs such as morphine.
Eur J Pharmacol 1977 Dec 15
PMID:An effect of beta-melanocyte stimulating hormone (beta-MSH) on alpha-motoneurones of cat spinal cord. 59 Mar 41

The analgesic effects of intracerebroventricular administration of alpha, gamma, and beta-endorphin and their D-Ala2-analogs were examined in the rat using the tail-flick test. Analgesia was produced by all substances. The actions of D-Ala2-alpha and -beta-endorphin were considerably greater than the parent forms, whereas D-Ala2-gamma-endorphin was approximately equivalent to the parent compound. The marked analgesia was dose dependent and prolonged for all analogs. Since these effects were reversed by the opiate antagonist naloxone, it was concluded that opiate receptors mediate the action of these analogs. It is suggested that these analogs may be useful in behavioral tests when a longer duration of action is desirable.
Pharmacol Biochem Behav 1977 Dec
PMID:Endorphin analogs with potent and long-lasting analgesic effects. 59 98

1 A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD-2 resin. Elution with methanol separates the enkephalins and alpha-endorphin from beta-endorphin.2 Over 90% of the opioid peptide activity isolated from brain and gut of several species by our method was due to methionine- and leucine-enkephalin. In contrast, the major opioid peptide activity recovered from the pituitary was due to peptides of much greater mol. wt. than the enkephalins.3 An opioid peptide with properties unlike those of the known endorphins or enkephalins was present in brain extracts. This peptide, termed epsilon-endorphin, has an apparent mol. wt. of 700 to 1200; it constituted between 5 to 10% of the total opioid activity in our extracts.4 A differential assay of methionine- and leucine-enkephalin was made either by destroying methionine-enkephalin activity with cyanogen bromide or by separating the peptides by thin layer chromatography.5 The ratio of methionine-enkephalin to leucine-enkephalin varied greatly in different brain regions. The highest proportions of leucine-enkephalin were found in the cerebral cortex and hippocampus.6 Formaldehyde perfusion and fixation of the brain in vivo had no significant effect on the brain content of enkephalin, indicating that proteolytic breakdown is not a major problem in the extraction of these peptides.7 It is suggested that the enkephalins may have a neurotransmitter role in both brain and peripheral tissues and that methionine- and leucine-enkephalin may subserve separate neuronal functions.
Br J Pharmacol 1977 Dec
PMID:The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. 59 68

The effects of 5-fluorouracil (5-FU), 1,3 bis(2-chloroethyl)-1 nitrosurea (BCNU) and cyclophosphamide on plasma levels of corticosterone, prolactin and thyroid stimulating hormone (TSH) were investigated. All the three drugs produce a remarkable adrenocortical activation but the duration of this effect is different. Hypophysectomized rats do not show any increase of plasma corticosterone levels in response to the considered antineoplastic agents. This may be indicative of an action mediated by adrenocorticotropic hormone (ACTH). The same drugs caused a significant fall of plasma TSH. Also the duration of this effect was different for the three compounds. No relevant modifications of plasma prolactin were observed.
Arch Int Pharmacodyn Ther 1977 Dec
PMID:Effects of some antineoplastic agents on plasma levels of corticosterone, prolactin and thyroid stimulating hormone. 60 26

Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.
Science 1978 Dec 01
PMID:beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa). 71 55

The in vivo equivalent of pA2 values were determined in rat tail-flick and mouse hot-plate tests for naloxone against morphine, beta-endorphin and a synthetic enkephalin analog, (D-Met2,Pro5)-enkephalinamide, as analgesics. In mice the apparent pA2 value of naloxone against morphine (6.86) was similar to that found by previously and essentially the same values were obtained against the opioid peptides, indicating homogenous receptor population for the analgesics studied. In rats the pA2 of naloxone against morphine (7.17) was lower than against either beta-endorphin (7.55) or (D-Met2,Pro5)-enkephalinamide (7.51), warning that in rats such a homogeneity of the "analgesic" receptor population as was observed for mice may not exist.
J Pharmacol Exp Ther 1978 Dec
PMID:In vivo antagonism by naloxone of morphine, beta-endorphin and a synthetic enkephalin analog. 73 37

Repeated intracisternal injections of human beta-endorphin lead to development of tolerance with respect to the catalepsy, analgesia, and hypothermia which are seen following a single injection. The initial injection of beta-endorphin results in increases in the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in neostriatum, as well as increases in the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in hypothalamus and brainstem and a decrease in 5-HIAA in hippocampus. In the present study, we report changes in metabolism of dopamine and serotonin in specific brain areas during the development of tolerance to beta-endorphin. Thus, the development of tolerance to beta-endorphin with respect to catalepsy, analgesia, and hypothermia may be mediated by development of tolerance to the effects of beta-endorphin on brain dopamine and serotonin release.
Can J Physiol Pharmacol 1978 Dec
PMID:Alterations in brain dopamine and serotonin metabolism during the development of tolerance to human beta-endorphin in rats. 74 24

Androsterone sulfate (5alpha-androstan-3alpha-ol-17-one, 3-sodium sulfate) administered to freely moving rats via cerebroventricular cannulae induced analgesia, wet-dog shakes, body jerks, rigidity, Straub tail, hypermotility, excessive grooming, hyperreactivity to stimuli, aggression, escape behavior, EEG spiking, and behavioral and EEG seizures. These responses resemble those produced by certain opiate drugs and by beta-endorphin, an endogenous peptide; they appear during the 5-min infusion period, persist in some cases for several hours, and are diminished by pretreatment with the narcotic antagonist naloxone. These findings indicate that steroid hormones can act upon at least some of the same central pathways influenced by recognized opiate compounds.
Can J Physiol Pharmacol 1978 Dec
PMID:Opiate-like naloxone-reversible effects of androsterone sulfate in rats. 74 33

The alpha-MSH levels in the frog hypophysis were measured by use of a sensitive ans specific radioimmunoassay. Sephadex G-50 gel chromatography of frog pars distalis and pars intermedia extracts showed that frog hypophyseal MSH was chemically related to synthetic alpha-MSH. Rat tissue homogenates were capable of degrading frog pars intermedia MSH as well as synthetic alpha-MSH. These results provide evidence that the frog hypophysis--pars intermedia and pars distalis--contains an alpha-MSH-like peptide.
C R Acad Hebd Seances Acad Sci D 1976 Dec 08
PMID:[Melanotropic hormone in the green frog (Rana esculenta): biochemical and radioimmunological study]. 82 75


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