Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ascending connections from the brainstem to the dorsal division of the lateral geniculate nucleus were examined using retrograde transport of horseradish peroxidase. Labelled cells were identified in a variety of structures, including the nucleus of the optic tract (NOT), the posterior pretectal nucleus (NPP), the superior colliculus (SC), the parabigeminal nucleus (PBN), the midbrain reticular formation (MRF), locus coeruleus and nucleus sub-coeruleus, the substantia nigra (SN), and parts of the raphe complex. The projections from NOT, NPP, MRF, LC and PBN were all bilateral in origin. The most intense labelling was observed in the nucleus of the optic tract and the superior colliculus. Colliculo-geniculate cells were located primarily in the superficial gray (lamina II1 and II2 of Kaneseki and Sprague (1974), but sparse labelling was also observed in lamina II3 and in statum opticum (lamina III). Consistent with the report of Harrell et al. (1982), these cells represent a morphologically diverse population, which includes stellate cells, granule cells, and both vertical and horizontal fusiform cells. A similarly diverse population of cell types contributes to the geniculate projection arising from NOT. These results confirm and extend earlier descriptions of the brainstem projections to the cat LGNd, and serve to emphasize the diversity of brainstem influences over the geniculate.
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PMID:Brainstem afferents to the lateral geniculate nucleus of the cat. 672 45

Acid phosphatases of the rat ventral prostate were fractionated by gel filtration (GF) on Sepharose 6B, isoelectric focusing (IEF), and chromatofocusing (CF). In GF three activity peaks (GF-1, GF-2, GF-3) were disclosed. They showed some differences in substrate preference when six substrates (p-nitrophenyl phosphate; p-NPP; phenolphthalein phosphate, Phe-P; thymolphthalein phosphate, Tym-P; alpha-naphthyl phosphate, alpha-NP; beta-naphthyl phosphate, beta-NP; naphthol ASBI phosphate, N-ASBI-P) were tested. Differences were also encountered in their sensitivity to tartrate and fluoride. IEF gave seven bands at different pI values (8.3, 8.1, 7.9, 7.1, 6.4, 5.5, and 5.0) with alpha-NP and beta-NP but only four with N-ASBI-P. Four of the bands (8.3, 8.1, 7.9, 5.5) were sensitive to tartrate. In CF eight activity peaks (CF-1 to CF-8) were resolved with the six substrates. They differed from each other in pI values, pH optima, substrate preference, and modifier characteristics. Peaks CF-1 (pI 8.3, pH 5.5), CF-2 (pI 8.1, pH 4.2) and CF-3 (pI 7.9, pH 4.2) had a large substrate spectrum and high sensitivity to tartrate and fluoride. CF-4 (pI 7.1, pH 6.0) and CF-7 (pI 5.5, pH 4.2) were low in activity, preferred alpha-NP as substrate, and were moderately sensitive to tartrate. CF-5 (pI 6.4, pH 5.5) and CF-8 (pI 5.0, pH 5.0) were able to hydrolyse all substrates tested with moderate inhibition by tartrate. CF-6 (pI 6.0, pH 5.0) showed a relative preference for p-NPP and Phe-P with no hydrolysis of N-ASBI-P and Tym-P. Of these activities CF-6 and CF-7 were also clearly activated by Co2+. Peaks CF-6 and CF-7 appeared the most sensitive to p-chloromercuribenzoate. It is concluded that activities CF-1, CF-2, and CF-3 are lysosomal isoenzymes with minor structural differences. The others are possibly all nonlysosomal with greater biochemical differences. Some of them apparently represent the secretory form(s) of acid phosphatase in the rat ventral prostate.
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PMID:Separation of acid phosphatases in the rat ventral prostate by gel filtration, isoelectric focusing, and chromatofocusing. 683 62

Acid phosphatase activities were measured with five different substrates in the total homogenates as well as after gel filtration on Sepharose 6B and cellulose chromatography of bull, guinea pig, rabbit, and ram testes. The response of the hydrolysis rate to NaF (5 mmol/l), Co2+ (5 mmol/l) and Zn2+ (5 mmol/l) was also tested. In the total homogenate the hydrolysis of p-nitrophenyl phosphate was markedly activated by Co2+, while in the presence of Zn2+ an activation was recorded in guinea pig and some inhibition in the bull, rabbit, and ram testes. NaF caused a decline in the total acid phosphatase activity, particularly in guinea pig and ram. The gel filtration resulted in three separate activity peaks with p-NPP and beta-NP as substrates. N-ASBI-P, alpha-NP, and Tym-P gave only two peaks. After subsequent cellulose chromatography of the activities only peak II gave rise to two further activities. Peak I of gel filtration (enzyme I) was able to hydrolyze all substrates tested and was highly sensitive to NaF. Peak I of cellulose chromatography (enzyme II) also hydrolyzed p-NPP and beta-NP. It was rather resistant to NaF but sensitive to Zn2+. It was slightly activated by Co2+. Peak II of cellulose chromatography (enzyme IV) hydrolyzed only p-NPP and was markedly activated by Co2+ and Zn2+. The adult testes of bull, guinea pig, rabbit, and ram have a closely similar testicular acid phosphatase pattern. Due to relative differences in the concentrations of the four enzymes in the tissue, varying activity levels are recorded in the presence of different substrate and modifier combinations.
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PMID:Testicular acid phosphatases in cattle, sheep, guinea pig, and rabbit. 741 53

Frequency of chromosome aberration was evaluated in 537 persons taken part in amelioration after the accident. The highest rate of aberration was found in covering builders and dosimetric: 3.24 +/- 0.25 and 3.11 +/- 0.43 per 100 cells, respectively. The mean rate of aberrations among the Chernobyl NPP staff was 2.37 +/- 0.20 per 100 cells, in the other examined groups the mean yield of aberration varied from 1.31 to 1.47 per 100 cells. The found aberration rates correspond to the equivalent whole body doses in the range from 131 to 515 mGy as evaluated by the established dose-response curve. In the group of covering builders the individual aberration rates varied more markedly, and corresponded to the equivalent whole body dose up to about 1 Gy. Slides of 27 individuals were checked by an automated dicentric scoring system. The results showed a satisfactory correlation between the frequencies of dicentrics per chromosome detected by routine and computer methods.
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PMID:[The cytogenetic effects in persons who suffered as a result of the accident at the Chernobyl Atomic Electric Power Station]. 748 97

Results of five years monitoring (1986-1991) of seed quality (SQ) and chlorophyll mutation frequency (MF) of Dactylis glomerata L., growing within 30-km zone of Chernobyl NPP are presented. It was shown that during initial postaccident period (1986, 1987) the criteria depend of the gamma-phone on the sampling plots. It was not found the correlation between SQ, MF and duration of plant growing under condition chronic irradiation.
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PMID:[The monitoring of natural populations of Dactylis glomerata L. in the area of the accident at the Chernobyl Atomic Electric Power Station]. 748 3

In three natural Crepis tectorum populations from 30-km zone of the Chernobyl NPP cytogenetic analysis of plant progenies was carried out. Germination capacity was not correlated with the dose rate of chronic irradiation. There was a correlation between frequency of cells with chromosome aberrations and frequency of seedlings with non-identical altered karyotype among which pericentric inversions and reciprocal translocations dominated. 9-chromosome altered karyotypes were found. Homozygous plants with altered karyotypes were not observed. Several heterozygous plants segregated homozygous seedlings with altered karyotype were found. In comparison with the second year after the accident in the third and fourth years there was stronger deviation from linear dependence between the cytogenetic effect and the dose rate of irradiation.
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PMID:[The cytogenetic effects in natural populations of Crepis tectorum exposed to chronic irradiation in the region of the Chernobyl Atomic Electric Power Station. An analysis of the frequency of chromosome aberrations and karyotype changes in the 3rd and 4th years after the accident]. 748 4

Cytogenetic analysis of seedlings from the seeds of four populations of Crepis tectorum plants grown during 7 years in localities of Bryansk Province contaminated with radioactive products was carried out. The frequency of chromosome aberrations in root meristematic cells was higher than at similar dose rates within 30-km zone of the Chernobyl NPP. At the same frequency of chromosome aberrations (induced at higher dose rates) karyotypes with pronounced frequency were observed in 30-km zone of the Chernobyl NPP. In Bryansk Province karyotypes were not found. This fact can be explained by the following: irradiation which induced the bulk of chromosome aberrations took place not at the stages of meiosis-early embryogenesis when the induction of chromosome aberrations leading to changed karyotype was more possible but after that.
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PMID:[The cytogenetic effects in Crepis tectorum populations growing in Bryansk Province observed in the 7th year after the accident at the Chernobyl Atomic Electric Power Station]. 748 7

A study was made of the protective effect of beta-carotine and ephasol against genetic damages in germ cells of male mice, exposed within the zone of Chernobyl NPP or ingested by 137Cs. The analysis of reproductive function, frequencies of dominant lethal mutations, abnormal sperm heads, reciprocal translocations and testis mass decrease show that both agents are more effective in protection against reproductive function damages than against genetic effects.
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PMID:[Modification of the genetic effect of radiation in mice exposed in the region of the Chernobyl Atomic Electric Power Station]. 748 15

Dynamics of 137Cs content in main types of animal production obtained in region of Russia contaminated as a result of the Chernobyl NPP accident, 1986, is described. Decrease of contamination of agricultural production during 1987--1992 was of not regular character. The most rapid decrease of 137Cs content in production was registered in the first post-accidental period which was connected with intensive realization of countermeasures in agriculture at that time. Half-life periods of 137Cs content (major dose-forming radionuclide) decrease in production for areas of Russia subjected to the most intensive contamination amounted of 1.6 to 4.8 years, as dependent on the scale of countermeasures carried out.
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PMID:[Regularities of changes in Cs-137 contents in animal products in the territory of the Russian Federation polluted as a consequence of the Chernobyl AES accident]. 755 Aug 91

Analysis of the dynamics of 137Cs content in the main kinds of plant and animal products obtained on the basis of a separate farm located at 40-50 km to the north from Chernobyl NPP has shown that in 1987-1991 the decrease of 137Cs transfer from soil to agricultural crops was on the average 2--4-fold, and for milk--6--7-fold during the pasture period and 10-fold--during stabling one. The half-life periods of decrease of 137Cs constant in the main kinds of plant production vary from 2.1 to 5.9 years; for milk this parameter equals to 1.4 years in the pasture period, and in the stabling one--2.8 years. The main contribution (67-80%) to the decrease of 137Cs transfer to plant products is made by biogeochemical processes causing decrease of mobility of 137Cs in soil; as for agrochemical countermeasures, these contribute 20--33%. Decrease of contamination of milk, on the contrary, is mainly due to realization of countermeasures--contribution of the latter reaches 60%.
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PMID:[Assessment of factors determining the dynamics of pollution by Cs-137 of agricultural production after the Chernobyl AES accident]. 755 Aug 90


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