Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of single and repeated maximal electroconvulsive shock (ECS, 150 mA, 50 Hz, 0.5 s) on the immunoreactive (ir-) dynorphin and beta-endorphin level in the rat brain, spinal cord and pituitary were studied. A single ECS induced a transient decrease in the hypothalamic ir-dynorphin, but did not influence the peptide content in the spinal cord, hippocampus and neurointermediate lobe of the pituitary. In contrast, the single ECS only slightly decreased the ir-beta-endorphin level in the hypothalamus, but caused a considerable fall in the peptide content in both lobes of the pituitary. A repeated ECS (every day for 9 days and 3 times a week for 3 weeks) markedly increased the ir-dynorphin content in the hypothalamus by 28 and 56%, respectively. Irrespective of the paradigm used, the repeated ECS strongly influenced spinal dynorphin neurons. At the beginning of our experiment (ECS applied 3 times) a fall in the peptide levels could be observed, but a longer treatment (ECS applied 9 times) led to its enhancement. The repeated ECS also induced a gradual decrease in the hippocampal ir-dynorphin level, followed by a long-term, rebound increase. In contrast to those numerous changes evoked in the dynorphin system, the repeated ECS did not evoke any changes in the hypothalamic and pituitary ir-beta-endorphin levels. As shown in the behavioral experiment, an acute ECS treatment resulted in a moderate increase in the pain threshold, measured by tail-flick and hot-plate tests. A prolonged ECS administration (3, 6 and 9 times) markedly enhanced the ECS-induced analgesia and catalepsy.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Single and repeated electroconvulsive shock differentially affects the prodynorphin and pro-opiomelanocortin system in the rat. 295 Sep 68

It has been established in experiments on conscious cats that variation in spontaneous activity of the midbrain reticular formation neurones in response to microiontophoretic application of morphine largely coincides with the pattern of changes in impulsation in response to administration of leu-enkephalin rather than to met-enkephalin. Concurrent application of the subthreshold dose of enkephalins and morphine has revealed a possibility of the effects summation, the highest pharmacological activity being exhibited by leu-enkephalin combined with morphine. Selective blocking by enkephalins and morphine has been observed of evoked neuronal responses to peripheral exposures (ECS, stimulation of the sciatic nerve). Meanwhile the responses of cortical origin have been found to remain unchanged.
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PMID:[Effect of enkephalins and morphine on the neurons of the midbrain reticular formation]. 712 79