Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The antinociceptive effects of the enantiomorphs of mexiletine (2-(2, 6-dimethylphenoxy)-1-methylethylamine monohydrochloride) and its main metabolite ((+/-)2-(2-hydroxymethyl-6-methylphenoxy)-1-methylethylamine oxalate: KOE2259) were studied in streptozotocin-induced diabetic mice using the tail-pinch and tail-flick test. Both (+)mexiletine and (-)mexiletine, at doses of 10 and 30 mg given i.p., produced dose-dependent inhibition of the tail-pinch response in diabetic, but not non-diabetic mice. On the other hand, KOE2259 had no significant effect on the tail-pinch response in both non-diabetic and diabetic mice. (+/-) Mexiletine given po also produced marked inhibition of the tail-pinch and tail-flick responses in both non-diabetic and diabetic mice. However, lidocaine, given either i.p. or po, had no significant effect on the tail-pinch response in both non-diabetic and diabetic mice. Intraperitoneal administration of mexiletine (30 mg/kg) significantly increased the serum beta-endorphin level in diabetic mice, but not in non-diabetic mice. These results indicate that both enantiomorphs of mexiletine produced an antinociceptive effect in diabetic mice. Furthermore, it is possible that the activation of the endogenous beta-endorphinergic system may be, at least in part, involved in the antinociceptive effect of mexiletine.
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PMID:[Antinociceptive effects of the enantiomorphs and its main metabolite in streptozotocin-induced diabetic mice]. 1089 18