Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01189 (
beta-endorphin
)
21,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We used the
met-enkephalin
analog (D-Met2,Pro5)-enkephalinamide (
DMPEA
) to investigate enkephalinergic control of
alpha-melanocyte-stimulating hormone
(
alpha-MSH
) secretion. Systemic (s.c.) administration of
DMPEA
elevated plasma titers of
alpha-MSH
in a dose- and time-related manner. Pretreatment with the opiate antagonist naltrexone had no effect on basal plasma levels of
alpha-MSH
but blocked
DMPEA
-induced
alpha-MSH
release. Treatment with a dose of naltrexone sufficient to block
DMPEA
-induced secretion of
alpha-MSH
had no effect on stress-induced secretion of
alpha-MSH
. Although pretreatment with the dopamine receptor agonist apomorphine prevented
DMPEA
-induced
alpha-MSH
secretion,
DMPEA
had no effect on the synthetic activity of tuberohypophysial dopamine neurons as gauged by measuring the accumulation of 3,4-dihydroxyphenylalanine in the neurointermediate lobe (NIL) following administration of NSD-1015. In vitro treatment of isolated NILs with
DMPEA
resulted in a significant increase in
alpha-MSH
release. Naltrexone completely blocked the stimulatory effects of
DMPEA
on
alpha-MSH
release in vitro. Our results indicate that
DMPEA
stimulates
alpha-MSH
secretion by acting directly through opiate receptors at the level of the NIL.
...
PMID:Effects of the enkephalin analog (D-Met2,Pro5)-enkephalinamide on alpha-melanocyte-stimulating hormone secretion. 823
