Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Behavioral effects of cholecystokinin (CCK) were observed in neofrontal decorticated and sham-operated rats. In the decorticated rats the cataleptic and analgesic effects of beta-endorphin were markedly enhanced. When CCK-antiserum was administered together with beta-endorphin, these effects were also enhanced. Sulfated CCK-8 decreased locomotion and rearing in open field test. Proglumide, a selective antagonist of CCK, blocked CCK-8-induced-hypomotility, but it had no influence on the actions of CCK-4. When general activity was monitored using an Automex, the activity counts markedly increased in the decorticated rats, while in the sham-operated rats such increase was not observed. Non-sulfated CCK-8 also stimulated the motility, particularly in the decorticated rats. On the other hand, CCK-4 was opposite to the results of CCK-8. In the decorticated rats rearing, sniffing and head stereotypy were increased by CCK-8, but grooming was not affected.
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PMID:Behavioral effects of cholecystokinin and its related peptides in rats. 293 43

The effects of proglumide, a cholecystokinin (CCK) receptor antagonist, on the analgesia and catalepsy induced by beta-endorphin were investigated in rats. Proglumide itself produced a slight analgesia but no catalepsy. Combined intracerebroventricular administration of beta-endorphin and proglumide produced marked potentiation of the analgesic and cataleptic effects of beta-endorphin. The results suggest that endogenous CCK may have an antagonistic effect on the actions of beta-endorphin in the brain.
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PMID:Potentiation of beta-endorphin effects by proglumide in rats. 315 51