Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Drug
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Target Concepts:
Gene/Protein
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Query: UNIPROT:P01189 (
beta-endorphin
)
21,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Adrenocorticotropic hormone
(
ACTH
)-induced hypertension in the rat is characterized by nitric oxide deficiency. Tetrahydrobiopterin (
BH4
) is an essential cofactor for the enzyme nitric oxide synthase and glucocorticoids have been reported to reduce cytokine-induced
BH4
production. Accordingly we hypothesized that
ACTH
-induced hypertension would be reversed by
BH4
supplementation. Male Sprague-Dawley rats (n = 33) were treated with
BH4
in vehicle (10 mg/kg/day i.p.) or vehicle alone (5 mg/kg/day i.p. of ascorbic acid in 4 mM HCl) for 10 days.
ACTH
(0.2 mg/kg s.c.) or saline daily injection was started 2 days after
BH4
or vehicle treatment and continued for 8 days. Systolic blood pressure (SBP) was measured on alternate days using the tail cuff method. Treatment with HCl, ascorbic acid or
BH4
alone had no effect on SBP. In saline treated rats, neither
BH4
nor its vehicle modified SBP. In
ACTH
treated rats, SBP was increased in both
BH4
(from 128 +/- 6 to 142 +/- 4 mmHg, T0 to T10, P < 0.0005, one way ANOVA) and vehicle groups (from 127 +/- 3 to 158 +/- 7 mmHg, T0 to T10, P < 0.001, one way ANOVA). There was no significant difference in SBP between
BH4
+
ACTH
treated and vehicle +
ACTH
treated rats. Thus, daily injection of
BH4
(10 mg/kg i.p.) failed to prevent the development of
ACTH
-induced hypertension in rat.
...
PMID:Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat. 1513 1
