Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We conducted this study to evaluate the effect of massage on the levels of endogenous opiates in peripheral venous blood. The results were based on findings from 21 healthy, adult volunteers. After separation by sex, the volunteers were assigned randomly to either the Control Group (n = 11) that rested but received no massage or the Experimental Group (n = 10) that received a 30-minute complete back massage. We found no significant pretreatment or posttreatment difference in blood beta-endorphin or beta-lipotropin levels between the groups. The results indicate that massage did not change significantly the measured serum levels of beta-endorphin or beta-lipotropin in our healthy subjects without pain. A follow-up study using patients experiencing acute or chronic back pain is recommended. Massage is used routinely in the treatment of such patients, and endogenous opiates are recognized as a possible mechanism for pain relief.
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PMID:Effect of massage on serum level of beta-endorphin and beta-lipotropin in healthy adults. 295 66

Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain. Both drugs produced significant decreases in depression, with an overall response rate of 70%; no significant difference was seen between groups. Pain ratings also decreased significantly in both groups (overall response rate = 50%); pain severity showed a better response to doxepin than to desipramine. While baseline pain, depression, and anxiety were correlated, treatment changes in these measures did not correlate. CSF beta-endorphin levels did not change with treatment. The usefulness of an antidepressant with anxiolytic properties, such as doxepin, is discussed.
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PMID:Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. 632 55