Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It s really hard to find a therapeutic tool used along 25 centuries; mud certainly is one. The remote empirism--not actually scientific--allows at least some kind of inferences; if the action of mud over the inflammatory process were neutral or harmful we should knew it. Mud has a place as a non-pharmacological tool in certain clinical settings, such as degenerative articular processes, skin disorders, and others. Babylonians knew its effects. Former scientific explanations regarding the mud action have been communicated in last years by some researchers. Fangotherapy in arthritis patients seems to cause variations in amino acid involved in cartilage homeostasis, and also produce reduction in pain ratings in gonarthrosis. Mud modifies nitric oxide, myeloperoxidase and glutathione peroxidase serum levels in arthritic patients and beta-endorphin and stress hormones in patients affected by osteoarthritis by reducing inflammation, pain and therefore diminishes the cause of stress. Has been confirmed that the thermal stress associated with Fangotherapy, activates the pituitary gland and the biochemical effects of peat components have aside from their physical-thermal effects. Furthermore, steroids and antimicrobial activity of certain therapeutic mud has been suggested.
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PMID:[Is mud an anti-inflammatory?]. 1802 Aug 95

The objective of the present study was to estimate the efficacy of pulsed laser radiation from a matrix radiator for the treatment of patients suffering osteoarthrosis of the knee joint. A total of 25 patients aged from 50 to 75 years with I-II stage gonarthrosis (GA) were enrolled (20 without synovitis and 5 with mild synovitis). Nineteen patients presented with oligoosteoarthrosis and six with polyosteoarthrosis. The state of capillary blood flow was assessed from the results of laser Doppler flowmetry (LDF) using a LAKK-01 laser analyzer of surface capillary blood flow (NPP "LAZMA", Russia). Prior to the treatment, all the patients with gonarthrosis had microcirculatory disturbances; based on their character, the patients were allocated to two groups in accordance with the classification proposed by V.I. Makolkin. Group 1 was comprised of the patients (92%) with the hyperemic type of microcirculation while group 2 included patients (8%) with its normnnocirculatory type. A single course of pulsed laser therapy resulted in the appearance of the signs of normalization of capillary blood flow. LDF revealed a physiological response of microvessels to pulsed laser radiation that manifested itself in the first place as the improvement of active mechanisms of regulation of microcirculation.
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PMID:[The use of the medical rehabilitation technology for the correction of microcirculatory disorders in the patients presenting with gonarthrosis]. 2269 37