Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01189 (
beta-endorphin
)
21,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Autotomy
and the concentrations of
beta-endorphin
and Met-enkephalin in brain areas and the spinal cord were measured in Sprague Dawley, Wistar and Wistar Lewis rats thirty-five days after the section of one sciatic nerve. As expected, autotomy developed in Sprague Dawley and Wistar, but not in Wistar Lewis rats. In the Wistar Lewis, brain and spinal cord concentrations of Met-enkephalin increased,
beta-endorphin
concentrations were unchanged. In Wistar and Sprague Dawley rats the increase of Met-enkephalin was accompanied by a decrease of
beta-endorphin
. Administration of chlomipramine, a drug usually employed in the treatment of deafferentiation pain, normalized the concentrations of
beta-endorphin
in the Sprague Dawley and Wistar rats, and avoided the development of autotomy, while Met-enkephalin concentrations did never change. The data presented suggest a possible correlation between
beta-endorphin
and autotomy.
...
PMID:Autotomy and central nervous system neuropeptides after section of the sciatic nerve in rats of different strains. 296 Sep 88
