Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors presented evidence for the effect of 6 analogues of ACTN4-10 on teaching of albino rats in a labyrinth with negative electrocutaneous reinforcement. Sixteen series of experiments on 192 rats demonstrated a positive effect of corticotropin fragments on memory processes. The activating ACTH fragment effect was shown in recording the background and bioelectrically induced rabbit brain activity in response to a photo-flash in 36 experiments on 18 animals. Three groups of 30 patients with alcohol withdrawal syndrome, posttraumatic craniocerebral effect and schizophrenia received injections of corticotropin as a therapeutic agent. A high efficacy of corticotropin in the treatment of the alcohol withdrawal syndrome and after effect of craniocerebral injury and a low efficacy and sometimes aggravation of symptoms in schizophrenia patients were shown.
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PMID:[Psychotropic properties of corticotropin and its analogs]. 300 19