Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The blood concentration of pituitary hormones (corticotropin, somatotropin, thyrotropin and prolactin) was studied in 145 male patients with aggravation of chronic pancreatitis and in 15 healthy male subjects. The pre-treatment concentration of corticotropin, somatotropin and thyrotropin was markedly increased and the level of prolactin had a tendency to decrease. By the end of treatment the level of thyrotropin and prolactin was fully normalized, the content of corticotropin had a tendency to decrease and the concentration of somatotropin somewhat decreased but did not reach the normal values. Changes in the blood level of pituitary hormones were more pronounced in the severe course of the disease and also when the level of pancreatic enzymes and hormones in the blood was high.
 ...
PMID:[Functional status of the hypophysis in patients with chronic pancreatitis]. 274 65

A 62-year-old man, receiving chronic haemodialysis and suffering from alcoholic liver cirrhosis and chronic pancreatitis, presented with hypoglycaemic coma. Plasma cortisol was undetectable (< 5.5 nmol/L) with suppressed adrenocorticotropic hormone (ACTH), which established a diagnosis of adrenal failure due to ACTH deficiency. Twenty-five milligrams of oral hydrocortisone eradicated hypoglycaemia. Presentation of adrenal failure in this patient was atypical because he was hypertensive, serum electrolytes including sodium were normal and anaemia was unremarkable, which were all due to end-stage renal disease and its treatment with haemodialysis. As far as we are aware, this is the first case report of hypoglycaemic coma due to adrenal failure in a chronic haemodialysis patient.
...
PMID:Hypoglycaemic coma due to adrenal failure in a chronic haemodialysis patient. 2598 98