Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01189 (
beta-endorphin
)
21,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The requirements for the activation of naive and memory CD8+ cytotoxic T (Tc) cells into effector virus-specific Tc cells after transferring them into
SCID
mice were investigated.
SCID
mice reconstituted with splenocytes or purified CD8+ T cells from naive or influenza-immune syngeneic mice and immunized with influenza virus generated effector Tc cells specific for influenza virus-infected target cells in vitro. The kinetics of the response varied between those two populations. The generation of effector Tc cells after transfer of memory CD8+ T cells indicates that there exists no absolute requirement for 'help' in the activation of memory virus-immune T cells. However, under the conditions described here the in vitro immunogenic peptide
NPP
derived from influenza nucleoprotein is not sufficient to elicit a response in vivo.
...
PMID:Transfer of CD8+ T cells into SCID mice and activation of memory virus-specific cytotoxic T cells. 846 35
