Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study we evaluated the presence of proopiomelanocortin-related peptides (beta-lipotropin, beta-endorphin, and gamma-endorphin) in five embryos (5 to 10 weeks of pregnancy) and 11 fetal pituitaries (15 to 25 weeks) by means of high-performance liquid chromatography coupled with specific radioimmunoassays. Tissues were collected at laparotomy for ectopic pregnancy (five embryos) or after spontaneous (seven) or prostaglandin-induced (four) abortion. beta-Endorphin and beta-lipotropin were present starting at the seventh week of pregnancy while gamma-endorphin appeared only in the second trimester. During embryonic life opioid activity was limited to the cephalic portion. The three peptides, but little, if any, acetylated 1-31 beta-endorphin, were recognized in the fetal pituitary throughout the second trimester, at which time beta-lipotropin and beta-endorphin showed constant values in spite of increasing gamma-endorphin concentrations. beta-Lipotropin was the predominant peptide in both embryonic and fetal life. In conclusion, the three peptides related to proopiomelanocortin were expressed from the precursor at different times throughout development. By the beginning of the second trimester the pituitary processing of proopiomelanocortin is similar to that of adult life and the functional activity of the anterior lobe seems to prevail over that of the "fetus-related" neurointermediate lobe around the twenty-fifth week of pregnancy.
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PMID:Ontogeny of pituitary beta-endorphin and related peptides in the human embryo and fetus. 295 Jul 61

Fallopian tube (FT) and endometrial urocortin 1 (Ucn1) and corticotropin-releasing hormone (CRH)-receptor (CRH-R1/CRH-R2) expression were examined using quantitative real-time polymerase chain reaction (RT-PCR) and immunohistochemistry in nonpregnant and pregnant women (intrauterine, IUP; ectopic pregnancy, EP). Tubal Ucn1 messenger RNA (mRNA) expression was higher in luteal compared to follicular phase (P < .01) and equivalent to follicular phase in FT from EP. Tubal CRH-R1/CRH-R2 mRNA was lower in luteal phase (P < .05) and in FT from EP compared to follicular phase (P < .01). Ucn1 mRNA was lower in endometrium from EP compared to IUP (P < .05). Corticotropin-releasing hormone-R1 mRNA was higher in endometrium from EP compared to viable IUP (P < .05). No differences were observed in CRH-R2 expression. Corticotropin-releasing hormone-R1 protein was primarily localized to epithelium of FT and endometrium. Quantitative analysis of tubal CRH-R1 protein expression reflected that seen at the mRNA level but endometrial expression was equivocal. The demonstration of attenuated tubal/endometrial Ucn1/CRH-R expression in EP further supports a role of the CRH-family in embryo implantation.
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PMID:Attenuated tubal and endometrial urocortin 1 and corticotropin-releasing hormone receptor expression in ectopic pregnancy. 2097 83