Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Autoradiography was used to investigate the presence of opioid receptors in soleus, extensor digitorum longus (EDL) and diaphragm muscles in two strains (C57BL/6J and C57BL/10) of mice which can inherit muscular dystrophy. Binding sites for two radiolabelled opioid ligands [125I]beta-endorphin and [3H]naloxone, were seen in a few muscle fibres in the normal mice. However, a significantly greater number of fibres exhibited the binding sites in the dystrophic individuals of both strains. The binding sites were not restricted to the endplate regions but were present over the entire surface in these fibres.
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PMID:Opioid receptors in skeletal muscle of normal and dystrophic mice. 217 5

Two derivatives of the stem hormone opiomelanocortin, alpha-melanotropin (alpha-MSH) and beta-endorphin, were detected immunocytochemically in the cell bodies and in the peripheral axon terminals of spinal motoneurones in immature but not in adult healthy mice. Immunoreactivity was demonstrated in motoneurones in both immature and adult mice with inherited muscular dystrophy. These results provide evidence for a motoneurone abnormality in murine dystrophy. The observations are discussed in the light of trophic influences over neuromuscular transmission which have been attributed to this family of neuropeptides.
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PMID:Presence of immunoreactive alpha-melanotropin and beta-endorphin in spinal motoneurones of the dystrophic mouse. 293 22