Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01189 (beta-endorphin)
 21,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma concentrations of corticotropin releasing hormone (CRH) and the serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, adrenocorticotropic hormone (ACTH) and cortisol were measured in seven physically active males after acute exercise on a treadmill using the Bruce protocol. Measurements were made in the basal pre-exercise state, immediately after exercise, and at 30-min intervals for 3 h after exercise. Serum LH concentrations declined following exercise reaching nadir values between 60 and 180 min after exercise (90 min post exercise in the group). The nadir values in individual volunteers were significantly lower than both the baseline and post-exercise levels. This fall in serum LH concentration appeared to follow a slight but significant elevation of the plasma concentration of CRH which reached peak levels when measured immediately post exercise. Plasma ACTH concentrations paralleled the rise in CRH, but fell to undetectable levels of below 13.8 nmol.l-1 (less than 5 ng.l-1) 60 min after exercise. Plasma cortisol concentrations peaked approximately 30 min after the rise in ACTH, after which they gradually declined to baseline levels. Plasma testosterone concentrations paralleled the concentrations of LH. The data suggest that CRH, on the basis of its previously described gonadotropin-depressant property, may be the hormone involved in the exercise-mediated decline in serum LH. Alternatively, some as yet unidentified factor(s), may be involved in producing the altered concentrations of both LH and CRH.
 ...
PMID:Corticotropin releasing hormone and gonadotropin secretion in physically active males after acute exercise. 164 5

The hypothesis that endogenous opioids may be involved in reduced exercise-induced ischemic pain or in silent ischemia was tested. Fifteen male patients with coronary artery disease were tested in a randomized, double-blind crossover study. After a preliminary screening effort test they were divided into two groups: the first group of nine patients received an i.m. injection of naloxone 0.4 mg, or saline as placebo, and the second group, comprising six patients, received 4 mg naloxone or saline i.v. Effort testing was performed at weekly intervals on an ergometric bicycle, following the Bruce protocol. ECG, heart rate, blood pressure and pain perception were monitored continually. Blood was sampled through an indwelling venous catheter for beta-endorphin determination before, at the peak of, and 10-20 min following exercise. ST depression, heart rate, blood pressure and the double product were similar after naloxone and following saline administration. Beta-endorphin concentrations in plasma were significantly increased following exercise in the second group of patients. The increase in beta-endorphin concentration was larger when the patients were pretreated with naloxone (4 mg) than with placebo. However, chest pain was not significantly altered by either dose of naloxone.
 ...
PMID:Asymptomatic or mildly symptomatic effort-induced myocardial ischemia: plasma beta-endorphin and effect of naloxone. 213 95

Today silent myocardial ischemia (SMI) is a well-recognized phenomenon. However, in the absence of clinical signs suggesting coronary artery disease (CAD), a streamlined diagnostic approach for precise clarification has proved to be difficult. Sensitivity and specificity of ergometric results are rather poor in symptom-free patients. Thus the question arises, whether the necessity of coronary angiography can be established more precisely by 201Tl myocardial SPECT in these patients. Treadmill exercise according to the Bruce protocol, 201Tl myocardial SPECT and coronary angiography were performed in a total of 106 patients with suspected SMI. In group I (high probability of ischemia; n = 46), reversible defects detected by SPECT correlated well with significant stenoses and irreversible defects with subtotal stenoses or complete occlusions. SPECT sensitivity in the detection of ischemia was 91%, its specificity 96%. In group II (low probability of ischemia; n = 60), SPECT sensitivity was as high as in group I (94%) but due to a high number of false-positive results (e.g. cardiomyopathy) specificity was only 75%. However, SPECT was superior to exercise ECG (sensitivity 70%; specificity 56%) in the detection of SMI. In addition, beta-endorphin levels were determined in 180 healthy subjects, 37 patients with symptomatic CAD and in 34 patients with SMI before and during maximum exercise. Exercise values in patients with SMI were significantly higher than in healthy subjects or in patients with symptomatic CAD.
 ...
PMID:201Tl myocardial SPECT and beta-endorphin levels in patients with suspected silent ischemia. 221 10

Although silent myocardial ischemia is a well recognized phenomenon, the reasons for the lack of symptoms in patients with coronary artery disease (CAD) is unclear. Because the endogenous opioid beta-endorphin has been related to pain modulation, plasma beta-endorphin levels were studied before, during and after exercise-induced ischemia in symptomatic and asymptomatic men. Because beta-endorphin responses have been closely linked to adrenocorticotropic hormone (ACTH) and cortisol responses, these hormones also were measured. Nine symptomatic and 12 asymptomatic patients with a high probability (at least 95%) of CAD and 8 apparently healthy men completed a Bruce protocol treadmill test. Blood samples were drawn before, during and 10 minutes after exercise. During exercise the measured hormones showed no significant increases from basal levels. However, plasma beta-endorphin, ACTH and cortisol levels were significantly elevated (p less than or equal to 0.01) 10 minutes after exercise in all 3 groups. There was no significant difference in plasma beta-endorphin levels during or after exercise between the symptomatic and asymptomatic patients with CAD. Thus, differences in circulating levels of beta-endorphin, ACTH and cortisol are not associated with the presence or absence of pain during exercise-induced myocardial ischemia.
 ...
PMID:Plasma beta-endorphin levels in silent myocardial ischemia induced by exercise. 303 88

Circulating brain natriuretic peptide (BNP) has recently served as a marker of left ventricular dysfunction, while treadmill exercise has been used clinically for assessing cardiac problems. The current study was undertaken to investigate the possible effect of exercise on circulating BNP concentrations. A total of 138 blood samples from 23 healthy men aged 23 to 27 years (mean, 25) was analyzed. All subjects maintained a similar diet and physical activity a week before the test. Plasma samples were drawn at baseline and immediately, 1 hour, 4 hours, 24 hours, and 48 hours after exercise. Every subject completed exercise according to the Bruce protocol with normal electrocardiogram (EKG) results. Specimens were simultaneously analyzed for concentrations of plasma BNP and other biochemical parameters including aldosterone (Aldo), adrenocorticotropic hormone (ACTH), cortisol, creatine phosphokinase (CPK), triiodothyronine (T(3)), and thyroxine (T(4)). Hematocrit (Hct), red blood cell count (RBC), and hemoglobin (Hgb) were analyzed immediately after each sampling. A transient increase in plasma BNP was found immediately after exercise (8.21 v baseline value, 3.38 pg/mL, P <.01). Twenty-two percent (5/23 subjects) had values above the normal limit (18.2 pg/mL). The Hct-corrected concentrations of plasma BNP were also significantly increased immediately after exercise compared with the baseline values (0.17 +/- 0.04 v baseline, 0.07 +/- 0.01, P <.01), but returned rapidly to baseline. Weak, but significantly positive, relationships were found between plasma BNP and T(3) and T(4). Our study demonstrates that circulating BNP values increase immediately after treadmill exercise in young adults. The elevation did not result from exercise-induced hemoconcentration. BNP concentration, however, returned to normal levels within 1 hour after exercise. Thus, we suggest that plasma samples should not be taken immediately after exercise to avoid possible artifacts.
 ...
PMID:Circulating brain natriuretic peptide values in healthy men before and after exercise. 1240 92