Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The role of lysine-vasopressin and oxytocin, as well as of their analog and fragment (DGAVP, desglycinamide arginine vasopressin; PLG, prolyl-leucyl-glycyl-amine), microinjected into the ventral hippocampus, in the formation and extinction of active avoidance conditioned reflex, was investigated. It was established that the introduction of lysine-vasopressin, as well as of its analog, into the hippocampus promoted the improvement of the formation of the avoidance reaction, while an inhibitory effect was elicited in the period of extinction of the skill. The opposite effects on the active avoidance reaction were obtained with oxytocin and its fragments. It is hypothesized that the observed behavioral changes in the active avoidance reaction are associated with the influence of these peptides on the processes of learning and memory.
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PMID:Influence of neurohypophyseal peptides on the formation of active avoidance conditioned reflex behavior. 197 96

The influence of intraperitoneal injection of vasopressin (LVP), oxytocin (OXY) and their fragments (DGAVP, PLG) on the acquisition and extinction of conditioned food reflex was studied in rats. It was found that vasopressin and its fragments had a more pronounced specific effect on the higher nervous activity of the animals. This effect consisted in impairment of the performance of the conditioned food reflex while oxytocin had a tendency to improve its performance. On the ground of the obtained data it is suggested that administration of vasopressin may facilitate the memory function only under specific environmental conditions.
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PMID:[Effect of neurohypophyseal peptides on the formation of a conditioned feeding reflex in the rat]. 287 98

Maintenance of intravenous heroin self-administration and the degree of tolerance to the analgesic effect of self-injected heroin were simultaneously measured in heroin-tolerant rats. Subcutaneous injection of oxytocin (OXT-(1-9)) and of its behaviorally active fragments desglycinamide9-oxytocin (OXT-(1-8)) and [pGlu4,Cyt6]-oxytocin-(4-8) (OXT-(4-8)) decreased the amount of heroin self-injected. The C-terminal tripeptide of oxytocin (prolyl-leucyl-glycinamide, PLG, OXT-(7-9)) and desglycinamide9-[Arg]8-vasopressin (AVP-(1-8] were ineffective in this respect. In spite of the lower amount of self-injected heroin after pretreatment with oxytocin fragments, no differences in the antinociceptive effect of self-injected heroin, as assessed by the lick response using a hot plate device, were observed after pretreatment with placebo and oxytocin fragments. These findings suggest that oxytocin and some of its behaviorally active fragments attenuate heroin tolerance and that this effect may result in a diminished heroin intake in tolerant animals self-injecting heroin.
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PMID:Behaviorally active oxytocin fragments simultaneously attenuate heroin self-administration and tolerance in rats. 405 58