Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sodium ion level disorders were analysed in 53 patients with porphyria during 84 acute attacks of the disease. Thirty two daily water-electrolyte balances in 6 patients treated at ICU were analysed in detail. A decrease in sodium ion levels in patients with porphyria is rather rare and most frequently transient during the acute attack of the disease. Noted disorders were not characteristic for the reported syndrome of the abnormal antidiuretic hormone release. The treatment of the acute attack of porphyria requires the achievement of the positive energy balance which leads to the normalization of sodium ion levels despite intensive hydratation of some patients.
Pol Tyg Lek
PMID:[A decrease in plasma sodium ion during the course of an acute attack of porphyria]. 248 16

Vasopressin (ADH) acts in humans mainly upon renal collecting tubules. By changing their water permeability it plays a key role in regulation of renal water excretion. Acting upon vascular smooth muscle cells, it causes vasoconstriction and raised arterial blood pressure. This hormone was also proven to cause constriction of cultured mesangial cels, it causes vasoconstriction and raised arterial blood pressure. This urea (Seldin, Giebisch 1985), to release the natriuretic hormone as well as to stimulate hepatic glycogenolysis (Abramov et al. 1987). The influence of vasopressin upon peritoneal transport of solutes was studied, too. ADH influenced the passage of phosphate and rubidium through the isolated rabbit mesentery (Berndt, Gosselin 1961) as well as sodium flux through isolated rabbit omentum (Shear et al. 1966). It caused the drop in urea dialysance in dogs subjected to peritoneal dialysis (Henderson et al. 1971). The subject of our study was the assessment of the action of the antidiuretic hormone under "in vitro" conditions upon the peritoneal transfer of urea, the solute present in human body fluids and removable by peritoneal dialysis.
Acta Med Pol 1989
PMID:Vasopressin-induced changes in permeability of peritoneal mesothelium for urea "in vitro". 248 58

This work was aimed to assess the secretion of volume related hormones in heart transplant patients (HTP) and their relationship to excretory renal function studied under bed rest and water immersion conditions. Fractional sodium (FENa%) and potassium (FEK%) clearance, plasma renin activity (PRA), plasma aldosterone (Ald), vasopressin (AVP) and atrial natriuretic peptide (ANP) were estimated in six HTP with moderate renal failure (C creat = 69 +/- 6.9 ml/min) and in 10 healthy subjects (N) (C creat = 110 +/- 2.0 ml/min). All HTP were treated with cyclosporine A and azathioprine. In HTP basal AVP (6.18 +/- 0.92 pg/ml) and ANP (138.17 +/- 14.69 pg/ml) levels were significantly higher than in normals (2.07 +/- 0.11 pg/ml and 74.10 +/- 7.10 pg/ml, respectively). HTP were also characterized by increased FENa% and FEK% both under bed rest (DI) and water immersion (WI) conditions. As abnormalities of excretory renal function in HTP were not significantly related to the plasma endocrine profiles factors other than PRA, Ald, AVP and ANP seemed to be also involved in their pathogenesis.
Acta Med Pol 1989
PMID:Renal response to central volume expansion induced by water immersion (WI) in heart transplant patients. 253 69

Administration of diazepam, an agonist of benzodiazepine receptors, and muscimol, an agonist of GABA(A) receptors, resulted in an increase in cytosol GABA-modulin in hypothalamus and cerebellum. Low dose of muscimol, ineffective by itself, completely antagonized the isoniazid, bicuculline and picrotoxin-induced decrease in GABA-modulin activity. In contrast, low dose of diazepam was able to block only the action of isoniazid. That confirms different mechanism of action of muscimol and diazepam. The increase in cytosol GABA-modulin activity in the anterior and posterior hypothalamus of spontaneously hypertensive rats (SHR) and of vasopressin hypertensive rats required much higher doses of muscimol than in normotensive animals showing subsensitivity of GABA(A) receptors in these brain structures. In contrast, the sensitivities of GABA(A) receptors in the cerebellum and of benzodiazepine receptors in the hypothalamus and cerebellum were equal to hypertensive and normotensive rats.
Pol J Pharmacol Pharm
PMID:The responsiveness of central benzodiazepine and GABA(A) receptors in vasopressin and spontaneously hypertensive rats. 256 66

We have synthesized three new analogues of arginine-vasopressin (AVP) to determine some of the structural features that account for antagonistic potency. These analogues are as follows: 4-glutamic acid (gamma-N,N-diethylamide)-8-arginine-vasopressin (I), N,N-diethylamide 1-(1-mercaptocyclohexaneacetic acid)-2-0-methyltyrosine- 4-glutamic acid (gamma-N,N-diethylamide)-8-arginine-vasopressin (II) and 1-(1-mercaptocyclohexaneacetic acid)-2-0-methyltyrosine-4-glutamic acid (gamma-glycine amide)-8-arginine-vasopressin (III). Analogues II and III are weak and moderate antagonists of the vasopressor response to AVP, respectively. Analogue III only exhibits a weak anti-antidiuretic activity. Analogue I lacks antagonistic effects in both systems.
Pol J Pharmacol Pharm
PMID:Synthesis and some pharmacological properties of three new analogues of arginine-vasopressin modified in positions 1,2,4 and 9. 258 42

The present study was designed to find out whether pressor responsiveness to vasopressin (AVP) is altered in spontaneously hypertensive rats (SHR) in comparison with their normotensive controls (WKY). Blood pressure and heart rate changes after injection of graded doses of 2.5, 5.0 and 10.0 ng of AVP (Calbiochem) i.v. were compared in 9 conscious, unrestrained spontaneously hypertensive (SHR) and 11 normotensive Wistar Kyoto (WKY) rats, chronically instrumented with venous and arterial catheters. The threshold dose necessary to elicit a significant increase in blood pressure and reduction of heart rate was lower in WKY than in SHR. At each dose level the blood pressure elevation persisted for a longer period in WKY than in SHR. Bradycardia was greater in WKY than in SHR both in absolute terms and in relation to the blood pressure increase. Thus, the results reveal diminished pressor responsiveness to moderate doses of AVP in SHR in spite of suppressed reflex bradycardia. It is suggested that the peripheral action of AVP on the vascular system is attenuated in SHR.
Acta Physiol Pol
PMID:Pressor responsiveness to vasopressin in spontaneously hypertensive rats. 264 16

Rats dehydrated for up to 8 days were given propranolol hydrochloride into the left brain ventricle in a daily dose of 10 micrograms. In euhydrated rats the single dose of propranolol diminished significantly the vasopressin content in neurohypophysis. In animals dehydrated for two days, the depletion of the neurohypophysial vasopressin storage was less marked under conditions of treatment with propranolol. At the fourth and eighth day of deprivation of water, propranolol did not modify the decrease of neurohypophysial vasopressin due to stimulation of osmodetectors.
Acta Physiol Pol
PMID:The vasopressin content in the neurohypophysis under conditions of intracerebroventricular beta-adrenergic blockade in euhydrated and dehydrated rats. 283 9

The effects of modified adrenergic transmission on the bioassayed storage of vasopressin and oxytocin in the hypothalamus and neurohypophysis under conditions of stress (cold or immobilization), disturbed water balance and pinealectomy are reviewed. Alpha-adrenergic mechanisms seem to be included in the response of vasopressinergic and oxytocinergic neurones to stress; on the other hand, impulses of osmoreceptor origin are of importance in regulatory processes affecting the functional response of these neurones to altered alpha-adrenergic transmission and also to melatonin. The beta-adrenergic (and, to some extent, also the alpha-adrenergic) transmission is probably involved in the neural mechanisms of the pineal-neurohypophysial relationship. Furthermore, a possible regulatory role of cholecystokinin in water metabolism and release of neurohypophysial hormones is suggested.
Acta Physiol Pol
PMID:Studies on the vasopressin and oxytocin storage in the hypothalamus and neurohypophysis. 284 Jul 99

[4-(0-methyl)-L-threonine]-oxytocin, a new analogue of neurohypophyseal hormone oxytocin, was synthesized. Its uretonic activity was found to be 150 I. U./mg. The comparison of the potency of [4-(0-methyl)-threonine]-oxytocin with a very active analogue [4-threonine]-oxytocin and low active analogue [4-isoleucine] -oxytocin supports the hypothesis of high uterotonic activity of 4-substituted analogue of oxytocin to be related to the presence of suitably located hydrophilic and lipophilic grouper in the side chain in position 4, and to the proton donor/proton acceptor properties of hydrophilic group.
Pol J Pharmacol Pharm
PMID:[4-(0-methyl)-L-threonine] -oxytocin. Synthesis and uterotonic activity. 285 67

The author reports the results of own experiments with administration of 8-arginine-vasopressin and ACTH4-10. In 79 cases of cerebrovascular disease improvement was observed after several doses of intranasal vasopressin. ACTH4-10 given to 10 patients with damage to the nervous tranks in extremities gave improvement in 8 cases. In experiments on rabbits ACTH4-10 accelerated axonal sprouting from the end of the damaged nerve as well as from the nearby nerves.
Neurol Neurochir Pol
PMID:[Use of neuropeptides in acute neurologic diseases]. 285 87


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