Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study aimed to assess the influence of opioid receptors on vasopressin (AVP) secretion in 12 kidney transplant patients (KTP) with stable graft function, and in 15 healthy subjects (control). Significantly lower basal plasma AVP levels were found in KTP than in controls. After blockade of opioid receptors by naloxone a significant increase of plasma AVP levels were observed in both examined groups. This increase was significantly higher in KTP than in healthy subjects. From data presented in this study participation of opioid receptors in the regulation of AVP secretion is highly likely both in KTP and controls. This participation seems to be significantly greater in KTP than in healthy subjects.
Pol Arch Med Wewn 1992 Oct
PMID:[Effect of opioid receptor blockade with naloxone on vasopressin secretion in patients with transplanted kidney]. 133 54

The thermal dehydration test was performed in 12 patients with renal transplant and in 20 healthy subjects. The study was aimed at the evaluation of the effect of volume regulating hormones on electrolyte composition of thermal sweat in patients with renal transplant. Blood plasma renin activity (PRA) as well as plasma concentrations of aldosterone (ALD), vasopressin (AVP) and atrial natriuretic peptide (ANP) were determined before and after thermal dehydration in all the subjects studied. In all the subjects sweat was also collected after 15 and 45 minutes of exposition to heat and the concentrations of sodium, potassium and chloride were determined in all sweat samples. Significantly elevated PRA and ANP concentrations and significantly lowered plasma AVP concentrations but normal ALD levels were found before thermal dehydration test in all the patients with renal transplant. After the exposition to heat lasting 1 hour the direction of changes was similar, their magnitude was, however, different in renal transplant patients than in healthy subjects. In addition, lower concentrations of sodium and chloride in thermal sweat and lower total concentration of sweat solids were found in renal transplant patients than in healthy controls. No significant correlation was found between the plasma concentrations of the hormones determined and the electrolyte concentrations of thermal sweat both in the renal transplant patients and in healthy subjects. The results suggest that the volume regulating hormones have no effect on the electrolyte composition of thermal sweat induced by short exposition to heat both in renal transplant patients and in healthy subjects.
Endokrynol Pol 1992
PMID:[Effect of thermal dehydration on blood levels of hormones regulating volume and electrolyte content of sweat in patients with kidney transplantation]. 134 26

The effect of ether stress and dexamethasone on hypothalamo-hypophyseal-adrenal axis was investigated in sexually mature male Wistar rats. Separate group of rats was subjected to ether stress during 2 minutes. The remaining animals were treated with dexamethasone during 7 days. CRF-immunoreactive and vasopressin-immunoreactive neurons were detected within paraventricular nuclei and median eminence by using specific antibodies. Body weight of the rats as well as the weights of pituitary and adrenal glands were also measured. The levels of ACTH and corticosterone were determined in blood serum. It was found that the ether stress caused a considerable decrease in the amount of CRF-immunopositive substances in the outer layer of median eminence and a decrease in the amount of vasopressin-immunoreactive neurocytes in the parvocellular fragment of paraventricular nuclei. Dexamethasone administration caused an increase in the amount of CRF-immunopositive perikaryons within paraventricular nuclei and also an increase in vasopressin-immunopositive nerve fibers in median eminence.
Endokrynol Pol 1992
PMID:[Studies of the hypothalamo-hypophyseal corticoliberin system. VII. Effect of ether stress and dexamethasone on the hypothalamo-hypophyseal-adrenal axis]. 134 39

Authors present a case of 28-year old female with anterior hypopituitarism and diabetes insipidus, with properly functioning anterior pituitary cells as showed by means of measuring pituitary hormones in response to neurohormones i.v. injections. Magnetic resonance imaging revealed neoplastic tissue in the pituitary stalk destroying supraopticohypophysial and paraventriculohypophysial tracts, as well as portal blood system, thus preventing release of vasopressin and these hypothalamic neurohormones from accessing anterior pituitary.
Endokrynol Pol 1992
PMID:[A case of pituitary stalk tumor diagnosed with magnetic resonance (MRI)]. 134 62

The literature data regarding the vasoconstriction potency of natural vasopressin-like peptides are contradictory. The cumulative concentration-response curve for arginine-vasopressin (AVP), lysine-vasopressin (LVP), arginine-vasotocin (AVT), lysine-vasotocin (LVT) and phenypressin (PHP) on the isolated rat tail artery was determined. The potency rank of these peptides on the vascular smooth muscle of the rat tail artery was the following: AVP greater than LVP greater than AVT = LVT greater than PHP. The results are discussed in comparison to the data in the literature.
Pol J Pharmacol Pharm
PMID:Vascular action of natural vasopressin-like peptides in isolated rat tail artery. 140 17

In an effort to develop more effective and selective V2-antagonists of arginine-vasopressin (AVP) we designed and synthesized four new analogs of this hormone. The peptides were designed in order to explore how the combination of modification of thioacids occupying position 1 and substitutions of positions 2 and 4 by D-Phe and Ile respectively, will influence their antagonistic properties. Three of the reported analogs are moderately potent V1/V2 antagonists.
Pol J Pharmacol Pharm
PMID:Synthesis and some pharmacological properties of new V1/V2 antagonists of arginine-vasopressin with structural changes at their N-terminals. 140 18

Iloprost (ZK 36374; a stable prostacyclin analogue) increases basal as well as potassium-evoked vasopressin and oxytocin secretion from rat neurointermediate lobes in vitro. This finding suggests a possible regulatory role of endogenous prostacyclin in the release of neurohypophysial hormones.
Acta Physiol Pol
PMID:Effect of a prostacyclin analogue on the vasopressin and oxytocin secretion in vitro. 172

Investigations have shown the presence of a cardiodepressant factor in the fluid incubating the posterior pituitary lobe "in situ", which decreased contraction frequency of the isolated heart auricle (Acta Physiol. Pol., 1984, 35: 460-468). The influence on the spontaneous contraction frequency of the isolated heart auricle of the following synthetic neuropeptides was determined: substance P, leu-enkephalin, met-enkephalin, angiotensin II, arg-vasopressin, oxytocin, delta sleep-inducing peptide and atrial natriuretic factor. It was found that the investigated neuropeptides had no effect on the contraction frequency of the isolated auricle of the heart right atrium of two-day-old rat in a concentration from 2.1 x 10(-7) to 1 x 10(-3) mol/l in the bathing medium and it was concluded that their biological properties differ from the cardiodepressant factor.
Acta Physiol Pol
PMID:The lack of influence of some neuropeptides present in the posterior pituitary lobe on the frequency of spontaneous contraction of the isolated heart auricle. 172 1

The present study has aimed to answer the following questions: 1) to what extent does the profile of volume related hormones in patients with chronic renal failure (CRF) differ from that of healthy subjects, and 2) do volume related hormones influence the electrolyte composition of thermal sweat? Twelve hemodialyzed patients with CRF and 20 healthy subjects were examined before and after one hour exposition to humid heat. In all examined subjects the following parameters were assessed before and after thermal dehydration: plasma renin activity (PRA) and plasma aldosterone (Ald), vasopressin (AVP) and atrial natriuretic peptide (ANP) concentrations. In addition sodium, potassium, and chloride were estimated in thermal sweat collected after 15 and 45 minutes respectively of thermal exposition. Patients with CRF showed significantly higher values of PRA, Ald, AVP and ANP before thermal dehydration. After one hour of heat exposition a significant increase in PRA, Ald and AVP but a significant decrease of plasma ANP level were noticed in both healthy subjects and patients with CRF. The magnitude of plasma Ald and ANP alterations induced by thermal dehydration was significantly more marked in patients than in healthy subjects. A similar electrolyte composition of thermal sweat was found in both examined groups. No significant correlation was found between the plasma profile of volume related hormones and electrolyte composition of sweat both in patients and normals. Results presented in this paper suggest, that volume related hormones do not influence the electrolyte composition of thermal sweat both in healthy subjects and patients with CRF.
Pol Arch Med Wewn 1991 Dec
PMID:[Influence of thermal dehydration on blood values of hormones which regulate volume and composition of electrolytes in sweat of patients with ic renal failure treated with hemodialysis]. 181 85

[Lys8]-Conopressin G (L1), and [Arg8]-Conopressin S (A1) and their four analogs were synthesized using solid phase procedure. These analogs are [2-thiopropionic acid1, lys8]-conopressin (L2), [2-thiopropionic acid1, Arg8]-conopressin (A2), [cis-4-methyl-1-thiocyclohexaneacetic acid1, Lys8], conopressin (L3), and [cis-4-methyl-1-thiocyclohexaneacetic acid1, ARg8]-conopressin (A3). Behavioral and diuretic effects of all six peptides were compared with these of [Arg8]-vasopressin (AVP). Conopressin A1, and L1 and their analogs A2, A3, L2, L3, induced antidiuretic effects. After icv injection of some conopressins, barrel rotatory behavior of rats was observed.
Pol J Pharmacol Pharm
PMID:Conopressins and their analogs: synthesis, antidiuretic and behavioral effects. 182 26


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