Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01185 (
vasopressin
)
23,126
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
GLUTX1
or GLUT8 is a newly characterized glucose transporter isoform that is expressed at high levels in the testis and brain and at lower levels in several other tissues. Its expression was mapped in the testis and brain by using specific antibodies. In the testis, immunoreactivity was expressed in differentiating spermatocytes of type 1 stage but undetectable in mature spermatozoa. In the brain,
GLUTX1
distribution was selective and localized to a variety of structures, mainly archi- and paleocortex. It was found in hippocampal and dentate gyrus neurons as well as amygdala and primary olfactory cortex. In these neurons, its location was close to the plasma membrane of cell bodies and sometimes in proximal dendrites. High
GLUTX1
levels were detected in the hypothalamus, supraoptic nucleus, median eminence, and the posterior pituitary. Neurons of these areas synthesize and secrete
vasopressin
and oxytocin. As shown by double immunofluorescence microscopy and immunogold labeling,
GLUTX1
was expressed only in
vasopressin
neurons. By immunogold labeling of ultrathin cryosections microscopy,
GLUTX1
was identified in dense core vesicles of synaptic nerve endings of the supraoptic nucleus and secretory granules of the
vasopressin
positive neurons. This localization suggests an involvement of
GLUTX1
both in specific neuron function and endocrine mechanisms.
...
PMID:Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons. 1175 19
