Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of pressure-applied avian pancreatic polypeptide (APP), neuropeptide Y (NPY) and norepinephrine (NE) on the activity of putative vasopressin-synthesizing neurosecretory cells of the supraoptic nucleus were studied in pentobarbitone-anesthetized male rats. APP (17-170 microM) excited 80% (20/25), NPY (20 microM-2 mM) excited 23% (6/26) and NE (100-200 microM) excited 76% (26/34) of cells tested; no depressant actions were observed. However, simultaneously applied APP appeared to reduce the NE-evoked excitation in 4/4 cells tested. These data indicate that an endogenous pancreatic polypeptide-like peptide may mimic the excitatory actions of NE on supraoptic vasopressin-synthesizing neurosecretory cells but only at high concentrations. These peptides do not potentiate but rather appear to interfere with NE's excitatory effects.
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PMID:Comparison between the actions of avian pancreatic polypeptide, neuropeptide Y and norepinephrine on the excitability of rat supraoptic vasopressin neurons. 384 86

In the suboesophageal ganglion of the Colorado potato beetle and the migratory locust three types of peptidergic neurosecretory cells were identified immunocytochemically with antisera to bovine pancreatic polypeptide, FMRFamide, vasopressin and alpha-MSH. Their locations and immunocytochemical reactions are similar, which suggests that these peptidergic cells in both insect species are homologous and perhaps have similar functions.
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PMID:Immunocytochemical demonstration of a homology in peptidergic neurosecretory cells in the suboesophageal ganglion of a beetle and a locust with antisera to bovine pancreatic polypeptide, FMRFamide, vasopressin and alpha-MSH. 609 Sep 97

The distribution of vasopressin-, vasoactive intestinal polypeptide-, somatostatin-, avian pancreatic polypeptide-, 5-hydroxytryptamine- and glutamic acid decarboxylase-like immunoreactivity was analyzed in the suprachiasmatic nuclei of male and female golden hamsters. Vasopressin. Vasopressin-like immunoreactivity is localized within neurons, dendrites and axons throughout the rostrocaudal extent of the suprachiasmatic nuclei. Immunoreactive perikarya are restricted to the dorsomedial aspect of each nucleus and occur in highest numbers within the intermediate two-thirds of the rostrocaudal axis. Axons containing vasopressin-like immunoreactivity form a dense plexus in the dorsomedial suprachiasmatic nuclei and in a vertical column at the lateral aspect of each nucleus. Somatostatin. Somatostatin-like immunoreactivity is also contained in neurons in the dorsomedial aspect of the suprachiasmatic nuclei and in thin varicose axons distributed throughout the suprachiasmatic nuclei in a pattern similar to that of vasopressin-immunoreactive axons. Vasoactive intestinal polypeptide. Vasoactive intestinal polypeptide-immunoreactive neurons are concentrated in the ventrolateral portion of each nucleus and occur almost exclusively within the intermediate two-thirds of the rostrocaudal axis. An extremely dense plexus of varicose axons exhibiting vasoactive intestinal polypeptide-like immunoreactivity extends throughout the suprachiasmatic nuclei and passes out of the dorsal aspect of each nucleus into the periventricular and anterior hypothalamic areas. Avian pancreatic polypeptide. Avian pancreatic polypeptide-like immunoreactivity is restricted to axons which arborize within the ventrolateral aspect of each nucleus. These fibers extend throughout the rostrocaudal extent of each nucleus and partially overlap the terminal field of retinal afferents. Glutamic acid decarboxylase. A very dense plexus of axonal varicosities exhibiting glutamic acid decarboxylase-like immunoreactivity fills both the dorsomedial and ventrolateral portions of the suprachiasmatic nuclei throughout the rostrocaudal extent of each nucleus. Lightly stained immunoreactive perikarya also occur throughout the suprachiasmatic nuclei. 5-Hydroxytryptamine. 5-Hydroxytryptamine-like immunoreactivity is restricted to axons which form a plexus in the ventromedial portion of each nucleus that is most dense in the intermediate two-thirds of the rostrocaudal axis.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:The suprachiasmatic nucleus of the golden hamster: immunohistochemical analysis of cell and fiber distribution. 615 Nov 47

Transplantation of embryonic neocortex into adult host neocortex leads to the survival of many donor cells, with the subsequent differentiation of the cortical neurons within a loosely laminated cellular pattern. We wanted to know whether peptide-containing neurons that are known to exist in normal neocortex would survive in the transplants, and if so, whether they would differentiate into morphological cell types that normally contain these peptides in cortex. By 30 days after transplantation, the implants were well vascularized and the donor neurons appeared healthy in Nissl-stained preparations. AChE-positive axons grew across the interface and innervated the transplant in moderate densities. Immunocytochemical localization of peptides in the transplant revealed that processes containing the four peptides normally present in cortex also develop in the transplants. These were vasoactive intestinal polypeptide, cholecystokinin, pancreatic polypeptide and somatostatin. Other peptides not yet demonstrated in and presumably not present in neocortex, did not develop in the transplants. These included alpha-melanocyte stimulating hormone, arginine-vasopressin, corticotropin releasing factor, beta-endorphin and substance P. The results demonstrate that peptide-immunoreactive neurons survive in neural transplants, where they develop complicated patterns of axonal arborization. The conditions used in these experiments produced no evidence that peptidergic neurons within the transplant grow out of the transplant and into the host brain within six weeks. Similarly, host peptidergic axons were never seen crossing the interface zone and entering the transplant in any significant numbers.
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PMID:The development of peptide-containing neurons within neocortical transplants in adult mice. 620 Aug 65

The 41-residue ovine corticotropin releasing factor (CRF) was administered iv and intracerebroventricularly (icv) to merino sheep. A significant rise in plasma ACTH, beta-lipotropin (beta LPH) and cortisol was demonstrated after the administration of 200 micrograms, iv. A highly significant correlation between the increments in plasma ACTH and beta LPH was observed. The plasma ACTH rise was evident within 5 min and was abolished by the prior administration of 0.4-4.0 mg dexamethasone. No significant rise in plasma GH, LH, PRL, insulin, glucagon, pancreatic polypeptide, met-enkephalin, angiotensin II, aldosterone, or vasopressin could be demonstrated. Although smaller doses of CRF (50 ng to 5 micrograms) were effective when given icv, the ACTH response was more delayed. It is concluded that CRF stimulates a rapid increase in the secretion of ACTH and beta LPH in sheep. Suppression of this response by dexamethasone indicates that glucocorticoids are capable of acting on the pituitary to inhibit the ACTH response to CRF. The delayed response when CRF is given icv may be due to diffusion. The action of CRF appears to be relatively specific, in that the plasma concentrations of the other pancreatic, pituitary, and adrenal hormones measured were not affected.
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PMID:The hormonal actions of corticotropin-releasing factor in sheep: effect of intravenous and intracerebroventricular injection. 630 69

Antisera against vasopressin, vasotocin, oxytocin, neurophysin-1 and neurophysin-2 were used to investigate immunocytochemically the presence of neurons containing substances antigenically related to these peptides in the nervous system of the Colorado potato beetle. Ten different antisera were used, four against vasopressin, three against oxytocin and one against vasotocin, neurophysin-1, and neurophysin-2. Immunoreactivity was shown by all antisera except those against the neurophysins. The vasopressin antisera all gave different results. One antiserum revealed only a single neuron pair, whereas others revealed in addition one or two other different cell groups. The oxytocin antisera likewise revealed different neurons. The fixation procedure influenced the outcome of the immunocytochemical reaction. Immunoreactivity as revealed by vasopressin, vasotocin and oxytocin antisera is often co-localized in the same neurons; solid phase adsorptions showed that this is due to cross-reactivity of the antisera. Some of the immunoreactive neurons are identical to those recently described to contain a bovine pancreatic polypeptide/FMRFamide-like peptide. This co-localization is probably not due to a cross-reaction. These findings indicate the presence of several vasopressin-like and oxytocin-like substances which in the Colorado potato beetle all have a different degree of immunocytochemical resemblance to vasopressin and oxytocin.
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PMID:Immunocytochemical localization of peptidergic cells in the neuro-endocrine system of the Colorado potato beetle, Leptinotarsa decemlineata, with antisera against vasopressin, vasotocin and oxytocin. 646 20

The suprachiasmatic nucleus has been identified tentatively as a circadian pacemaker. To examine the functional role of peptides found within suprachiasmatic neurons, avian pancreatic polypeptide and vasopressin were microinjected into the suprachiasmatic region. Avian pancreatic polypeptide, but not vasopressin, shifted the phase of the wheelrunning rhythm as a function of the time of its injection within the circadian cycle. Avian pancreatic polypeptide or a similar peptide may be one component of the neurochemical processes underlying entrainment to the light-dark cycle.
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PMID:Avian pancreatic polypeptide phase shifts hamster circadian rhythms when microinjected into the suprachiasmatic region. 654 54

Endocrine abnormalities in patients with chronic renal failure are well documented. The present study aimed to assess the influence of long-term erythropoietin (EPO) therapy on endocrine abnormalities in hemodialyzed patients. Two groups of hemodialyzed patients, each of which comprised 17 subjects, were examined. The first group was treated by EPO (EPO group) while the second one did not receive this hormone (No-EPO group). A complete biochemical and hormonal check-up was performed before and at the 3, 6, 9, and 12 month points of the study period. Normal values for the estimated parameters were obtained in appropriately selected sex- and age-matched healthy subjects. After EPO therapy, an increase of the hematocrit value from 21.8 +/- 0.9 to 32.6 +/- 0.9% was observed, which was accompanied by a significant decline of plasma ferritin and saturation of transferrin. In patients of the No-EPO group, a significant although less marked rise of the hematocrit value (21.4 +/- 0.4 to 24.2 +/- 0.6%) was also noticed. EPO therapy did not change plasma levels of electrolytes (Na, K, Ca, inorganic phosphate), osteocalcin, creatinine, glucose, and alkaline phosphatase as well as plasma concentrations of calcium-related hormones (PTH, calcitonin, 1,25[OH]2D3), vasopressin, and triiodothyronine. EPO treatment induced a significant decrease in somatotropin, prolactin, follitropin, lutropin, ACTH, cortisol, plasma renin activity, aldosterone, noradrenaline, adrenaline, dopamine, glucagon, pancreatic polypeptide, and gastrin plasma levels and an increase in plasma insulin, estradiol, testosterone, atrial natriuretic peptide, thyrotropin, and thyroxine.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Function of endocrine organs in hemodialyzed patients of long-term erythropoietin therapy. 762 22

Cardiovascular and hormonal responses to anaphylactic shock were evaluated in anaesthetized pigs sensitized by natural exposure to Ascaris suum as verified by antibodies. In six animals with such antibodies, Ascaris antigen injection produced a plasma histamine increase of 52 (42-196) fold (median and range; P < 0.05), while four pigs without such antibodies served as controls with only insignificant increases in histamine. In the anaphylactic group, two of the animals died during the investigation due to cardiovascular collapse. In the sensitized pigs resting heart rate (HR), 104 (86-118) beats min-1, increased to 204 (164-240) beats min-1 as mean arterial pressure (MAP) decreased from 94 (83-102) to 45 (31-90) mmHg (P < 0.05). In contrast, the non-sensitized pigs maintained the resting HR of 101 (79-113) beats min-1, as MAP decreased to 50 (41-97) mmHg (P < 0.05). In the sensitized group systemic vascular resistance (SVR) fell from 1114 (843-1811) to 990 (588-1173) dyne s-1 cm-5 and then increased to 3617 (2593-4166) dyne s-1 cm-5, while in the control group there was only a reduction to a minimum value of 730 (458-1307) dyne s-1 cm-5 (P < 0.05). Thoracic electrical impedance increased only in the sensitized group [from 28.3 (24.7-31.4) to 29.9 (24.0-31.4)], indicating central volume depletion. Plasma catecholamines increased markedly only in the sensitized pigs, and plasma pancreatic polypeptide, vasopressin, aldosterone and renin responses confirmed to those established during central hypovolaemia. During anaphylaxis, this study demonstrated cardiovascular responses similar to those established during a major blood loss. However, as indicated by plasma catecholamines, sympathetic activity was many times that previously demonstrated during haemorrhage, and sympathoactivation may explain the marked vasoconstriction noted in the sensitized pigs.
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PMID:Cardiovascular and hormonal responses to anaphylactic shock in the pig. 771 95

Effects of ileus on cardiovascular and hormonal responses to haemorrhage were evaluated in 10 anaesthetized pigs. Ileus was induced and the bleeding sequence repeated on the following day. Before ileus, a resting heart rate (HR) of 105 (range 83-140) beats min-1 remained unchanged until haemorrhage amounted to 15% of the blood volume. With a blood loss of 28% HR increased to a maximum of 162 (126-245) beats min-1. In contrast, ileus increased HR upon initiation of haemorrhage from a similar resting value to a maximum of 200 (152-250) beats min-1 (P < 0.0005). There were neither statistical differences in mean arterial pressure, cardiac output, central venous pressure, thoracic electrical impedance, pulmonary arterial mean pressure, pulmonary wedge pressure, pulmonary and systemic vascular resistances, nor in plasma concentrations of dopamine, adrenaline, vasopressin and aldosterone during haemorrhage before and after ileus. Plasma noradrenaline increased more with haemorrhage after than before ileus: from 2.8 (1.2-5.0) to 13 (2.3-59.0) vs. 3.0 (1.5-4.2) to 3.6 (2.7-17.5) nmol l-1 (P < 0.005). Also, the pancreatic polypeptide response to haemorrhage was enlarged with ileus (29 (0-60) to 90 (45-145) vs. 23 (0-64) to 57 (27-106) pmol l-1 (P < 0.005)). No significant differences could be detected in cardiovascular and hormonal responses to haemorrhage before and after a sham-operation in three pigs. Results demonstrate an immediate and enhanced HR response to haemorrhage in the pig with ileus, reflected in sympathetic activation as indicated by plasma noradrenaline.
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PMID:Enhanced heart rate response to haemorrhage by ileus in the pig. 831 Aug 34


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