Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The toxicities of adrenalin, nor-adrenalin and vasopressin derivatives were compared on the basis of animal tests, among others. The adrenalin additive is rejected.
Dtsch Zahnarztl Z 1975 Sep
PMID:[Toxicity tests in vasoconstrictor agents added to local anesthetics]. 106 May 57

A bleeding gastric ulcer was surgically created in 18 dogs, and the left gastric artery was successfully catheterized by percutaneous techniques in 15. Nine of these dogs were treated with vasopressin infusion which did not arrest the hemorrhage. A total of 11 dogs (five of them following unsuccessful vasopressin therapy) underwent embolization with strips of Gelfoam, and hemorrhage stopped in ten. This technique of embolization is concluded to be of value in the management of gastric hemorrhage.
Radiology 1975 Sep
PMID:Gelfoam embolization of the left gastric artery for bleeding ulcer: experimental considerations. 108 Feb 82

Massive upper gastrointestinal bleeding was controlled in 11 of 15 patients by the use of selective injected arterial emboli. Embolization is most successful in the treatment of patients with demonstrated arterial bleeding sites at angiography. This group of patients generally has ulcers and it is this group in whom vasopressin infusion has the lowest success rate. At the same time we were successful in controlling only 1 of 4 patients who were bleeding from diffuse hemorrhagic gastritis, those patients in whom vasopressin infusion is very successfu, We, therefore, now embolize only patients in whom arterial bleeding sites are demonstrated at angiography or in whom vasopressin infusion has failed to control the bleeding from hemorrhagic gastritis. Our experience also indicates that short acting occlusive agents, such as autogenous blood clot mixed with aminocaproic acid, are as successful in controlling bleeding as the more permanent types of embolic material.
Am J Roentgenol Radium Ther Nucl Med 1975 Sep
PMID:Selective arterial embolization for control of massive upper gastrointestinal bleeding. 108 39

Alterations in gastric physiology caused by selective embolization and vasopressin infusion of the left gastric artery were evaluated in 29 dogs. Gastric acidity was not significantly altered following Gelfoam embolization but decreased sharply with vasopressin infusion. These results suggest that the segmental occlusion caused by Gelfoam embolization permits significant collateral blood flow to the gastric mucosa, while the arteriolar and capillary constriction caused by vasopressin effectively decreases mucosal blood flow. These findings are consistent with the clincal observation that embolization is more effective in controlling bleeding ulcers, while vasopressin infusion is more effective for controlling hemorrhagic gastritis.
Radiology 1976 Sep
PMID:Alterations in gastric physiology caused by selective embolization and vasopressin infusion of the left gastric artery. 108 10

Neurophysiological, neurochemical and behavioral studies of the effects of ethanol on the nervous system have so far failed to identify specific, direct, primary mechnisms of action that may account for the typical pattern of alcohol intoxication in vivo. Electroencephalogram and evoked response studies indicate biphasic effects in the intact subject, which may correlate better with the level of arousal than with a specific drug action. Effects on spinal reflexes are also biphasic, probably representing the net result of direct influence on resting membrane potential, primary afferent depolarization, and neurotransmitter release. With the exception of its inhibitory effect on release of oxytocin, vasopressin and possibly other hypothalamic peptides, ethanol does not appear notably different in its spectrum of effects from a wide range of other hypnotics, anesthetics and minor tranquilizers. Interpretation of the findings is complicated by the fact that functional alteration of any given neuronal system by ethanol in vivo may reflect a) direct local action of ethanol on the cells under study, b) change in the input to those cells because of an action elsewhere in the nervous system, c) effects of ethanol metabolites, or d) indirect consequences of decreased blood flow, oxygen or metabolite supply, hormonal action, or hypothermia, due to disturbances of homeostasis in the whole body as a result of deep intoxication. To date, attempts to circmvent b, c and d by the study of brain tissue in vitro have shown consistent effects of ethanol only at concentrations well above those that are meaningful in vivo. Relatively specific patterns of action of different drugs in vivo may prove to be largely dependent on their customary rates and routes of administration, and on summation of minor differences in the dose-response curves with different types of neuron, even though the basic types of molecular action may be essentially similar.
Fed Proc 1975 Sep
PMID:Direct effects of ethanol on the nervous system. 109 39

The authors describe three postmenopausal women with agitated psychotic depression, increased water ingestion, and electrolyte values consistent with the syndrome of inappropriate antidiuretic hormone (ADH) secretion. They hypothesize that this clinical triad represents a syndrome reflecting underlying dysfunction of the hypothalamus and limbic system of the brain. The diagnosis of inappropriate ADH in one of the patients was directly confirmed by a recently developed serum radioimmunoassay.
Am J Psychiatry 1975 Sep
PMID:Acute psychosis, increased water ingestion, and inappropriate antidiuretic hormone secretion. 115 26

A direct relationship was observed between the percentage inhibition of secretin-stimulated pancreatic exocrine flow and the dose of antidiuretic hormone administered with the minimal effective concentration being 0.75 m units/kg or 0.012 m units/ml. An alteration in the molecular configuration of the antidiuretic hormone modified its ability to inhibit secretin-stimulated pancreatic exocrine secretion.
Am J Dig Dis 1975 Sep
PMID:Inhibitory action of antidiuretic hormone on canine pancreatic exocrine flow. 116 20

The vasoconstrictors angiotensin II, vasopressin and the alpha-sympathomimetic phenylephrine significantly inhibit the renin release caused by the beta-sympathomimetic isoprenaline. The mechanism of the inhibition is discussed.
Experientia 1975 Sep 15
PMID:Inhibition of isoprenaline-induced increase in plasma renin concentration by vasoconstrictors. 117 48

The hydrated goat was used for bioassays of antidiuretic hormone (ADH) activity recovered by resin column separation from the urine of other animals of the same species. A methodological innovation in the separation procedure was ethanol purification of the column before elution. In this manner substances which sometimes obscured the bioassays were eliminated without loss of ADH activity. With the bioassay method employed, it was possible to determine to the nearest 0.5 of a mU the ADH activity of unknown samples, provided they contained between 0-5 mU of ADH. When arginine vasopressin was infused intravenously into hydrated animals, slightly more than 10% of its antidiuretic activity was recovered in the urine. In the water replete goat the ADH activity found in the urine was of the order of 1 mU per hr urine secretion, indicating a neurohypophyseal ADH release of approximately 5 muU/kg min. After 48 h of dehydration in an environmental temperature of 20 degrees C the renal ADH excretion increased to about 8 mU/h, suggesting an 8-fold increase of ADH secretion over basic, water replete secretion of ADH. ADH secretion of the same high order was induced in hydrated animals by the infusion of angiotensin II together with hypertonic NaCl into the lateral cerebral ventricle.
Acta Physiol Scand 1975 Sep
PMID:Recovery of ADH activity in the urine of goats under normal and stimulated conditions. 118 95

Duriing water diuresis in conscious goats, noradrenaline (NA), its antagonists phentolamine, phenoxybenzamine and propranolol and also atropine were administered into the 3rd ventricle. The subsequent effects on water diuresis and on the excretion rates of Na+, K+ and Cl- were investigated. Infusion of NA into the 3rd ventricle induced a strong and significant antidiuretic response and a decrease in the Na+ : K+ excretion ratio; these effects were dose-dependent. High doses of NA produced a significant increase in urinary K+ excretion. Similar results were observed after i.v. administration of arginine-vasopressin. Pretreatment with phentolamine injected into the 3rd ventricle produced a dose-dependent inhibition of the NA-induced antidiuretic effects. Phenoxybenzamine also blocked the response to NA but a dose-response relationship was not apparent. Atropine and propranolol did not block the response to NA.
J Endocrinol 1975 Sep
PMID:Effect of intraventricular administration of noradrenaline on water diuresis in goats. 119 13


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