Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten male healthy volunteers were studied in order to determine whether the synthetic somatostatin analogue Sandostatin (SMS 201-995) has effects similar to those of natural somatostatin on renal water and electrolyte excretion. The study was carried out in three separate placebo-controlled randomized double-blind cross-over trials. The subjects received single sc injections of 100 micrograms Sandostatin and placebo under conditions of mild diuresis (trial 1), water load with enhanced diuresis (trial 2), and water load with exogenous lysin-vasopressin (5 IU sc) induced antidiuresis (trial 3). The following parameters were measured: urine flow rate, serum and urine osmolalities, osmolar clearance, free water and creatinine clearances, excretion rates of sodium, potassium, calcium, chloride, and phosphate, and immunoreactive insulin. A marked antidiuretic effect was observed within 2 h after dosing in all three trials. Urine flow rates were reduced by 45% in trial 1 and by 29 and 31% in trials 2 and 3, respectively (all P less than 0.05). There were no differences in effects on serum and urine osmolalities between Sandostatin and placebo. Osmolar clearance was significantly reduced in trial 1 (P less than 0.01). Free water clearance significantly decreased only in trial 2 (P less than 0.05). Sodium excretion decreased by 49, 48 and 67%, respectively, the differences being significant in trials 1 and 3 (P less than 0.05). Calcium excretion decreased by 66, 70 and 54% (all P less than 0.001). Chloride excretion decreased by 28, 22 and 44%, the differences being significant in trials 2 and 3 (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Antidiuretic effect of Sandostatin (SMS 201-995) in healthy volunteers. 265 54

Release of plasma ACTH- and beta-endorphin (beta-EP)-like immunoreactivity (LI) was studied in vivo in a patient with an ectopic ACTH-producing malignant thymoma. Administration of lysin vasopressin stimulated concomitant release of plasma ACTH- and beta-EP-LI. Administration of cyproheptadine, naloxone, and somatostatin significantly suppressed plasma levels of ACTH- and beta-EP-LI, while saline infusion did not. Gel exclusion chromatography of the plasma extracts revealed that ACTH-LI consisted of two components, large and small molecular weight form, while beta-EP-LI consisted of three components, large molecular weight, beta-lipotropin-, and beta-EP-sized form; each of these components was incompletely suppressed by somatostatin infusion. It is suggested that certain tumors may have acquired aberrant multiple receptors during malignant transformation which may lead to the paradoxical hormone response as demonstrated in this case.
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PMID:Concomitant suppression of plasma ACTH- and beta-endorphin-like immunoreactivity by cyproheptadine, naloxone, and somatostatin in the ectopic ACTH syndrome. 286 Nov 53

Triglycyl-lysin-vasopressin is a long-acting vasopressin derivative which is under consideration for the treatment of acute variceal bleeding in cirrhosis. However, its splanchnic hemodynamic effects have not been investigated thoroughly. In 11 patients with alcoholic cirrhosis, systemic and splanchnic hemodynamics were evaluated before and 20-40 min after intravenous administration of 2 mg triglycyl-lysin-vasopressin. Following the drug administration, heart rate decreased by 10% and cardiac index by 22% on the average, respectively; mean arterial pressure increased by 14% and systemic vascular resistence index by 48%. Hepatic venous pressure gradient showed a marked and persistent fall, averaging 31%. Hepatic and splenic blood flow decreased by 31% and 56%, respectively. A significant correlation was found between the decrease in hepatic venous pressure gradient and in splenic blood flow. By contrast, the decrease in the hepatic venous pressure gradient was not significantly correlated to the decrease in hepatic blood flow or in cardiac index. We conclude that in patients with alcoholic cirrhosis, triglycyl-lysin-vasopressin decreases portal pressure as well as hepatic and splenic blood flows. The decrease in portal pressure was due to the decrease in splanchnic blood inflow and not to the decrease in cardiac index.
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PMID:Hemodynamic changes of systemic, hepatic, and splenic circulation following triglycyl-lysin-vasopressin administration in alcoholic cirrhosis. 340 97

Behavioral effects of lysin-vasopressin (LVP) were investigated applying two paradigms from human experimental psychology. The first task was designed to simulate amnesic symptoms in normals. The second task addressed the emotional value of the items to be processed. Additionally, EEG recordings were used as indicators of the central nervous system effectiveness of LVP. Blood pressure and heart rate measured peripheral arousal. The co-twin control method was employed to increase experimental power. Contrary to the prediction of the vasopressin memory hypothesis none of the specific memory parameters was improved by LVP treatment. Changes in the electrical activity of the brain, but not in blood pressure and heart rate indicated central nervous system actions of LVP. However, interpretation of LVP effects in terms of memory processing seems not to be justified.
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PMID:Vasopressin does not enhance memory processes: a study in human twins. 404 Oct 34

Direct determination of cortisol (F) in human saliva and its clinical applications were investigated. For this purpose, a solid phase radioimmunoassay (RIA) was carried out. The detection limits for F in 50 and 400 microliter of saliva were 0.125 and 0.0156 micrograms/100 ml, respectively, and the intra-assay coefficient of variation was 5.9--12.2%. Salivary F levels measured by this method were in good agreement with those by the RIA after extraction with dichlormethane reported previously. Salivary F levels were studied in 10 healthy adults with regard to diurnal rhythms, in rapid ACTH tests, and following intravenous injections of 20 mg F, and they showed almost similar changes to serum unbound F levels. Diurnal variations of salivary F in 8 normal children were nearly the same as those in healthy adults. In patients with Cushing's syndrome, neither normal diurnal rhythm of salivary F nor suppressed salivary F with dexamethasone were observed. Patients with adrenocortical insufficiency showed a lack of responsiveness in salivary F levels to stimulation with ACTH or lysin-vasopressin. These findings suggest that salivary F can be measured directly by the solid phase RIA and accurately reflects serum unbound F. The method is simple, accurate and useful for assessing adrenocortical function, especially in pediatric subjects and/or outpatients.
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PMID:Direct assay of cortisol in human saliva by solid phase radioimmunoassay and its clinical applications. 627 17

Using 750 outpatients as our material, the effects of dimethicon , simethicon - pankreatin and lysin-vasopressin, of the position of the patient and of the filling of the stomach with soup on the success of pancreatic ultrasonography were studied. Dimethicon had no, simethicon - pankreatin an almost significant and lysin-vasopressin a highly significant positive effect. Lysin-vasopressin caused several mild adverse reactions. The filling of the stomach with soup combined with erect position was effective in about 3/4 of the cases. Prone position was not usefull.
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PMID:The effect of drugs, position of the patient and filling of the stomach on pancreatic sonography. 637 40

In chronic alcoholic patients with reduced ability for memorizing, lysin-vasopressin (LVP) exerts an obvious positive effect upon the involuntary long-term memory. The effect is more obvious in tests demanding a semantic processing of information rather than the automatic memorizing. Under the LVP effect, an enhancement of the alpha-rhythm synchronization occurs in the EEG. The maximal "inhibitory" effect of the LVP occurs against background of desynchronization with an initial increased level of unspecific ascending influences. The LVP rises the upper limit of the response in the form of the EEG rhythms rearrangement, i. e. it increases the lability of cerebral structures. In conditioning therapy of chronic alcoholism the LVP increases the negative reflex to ethanol formed on the basis of apomorphine. The data obtained reveal an essential acceleration and increased durability of conditioning to ethanol as the result of the LVP use.
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PMID:[Effect of vasopressin on long-term memory (psychophysiological and clinical aspects)]. 648 70

Intravenous injection of vasopressin (lysin-8-vasopressin, LVP) in unanesthetized rats at an ambient temperature of 18 degrees C caused a decrease in heat production (M) followed by a fall in colonic temperature (Tco1). These changes were preceded by an elevation of aortic blood pressure (BP) and bradycardia, and were related to the dosage of LVP administered. Temperature of the interscapular brown adipose tissue (BAT) significantly fell after LVP injections. Therefore, it can be said that the decrease in metabolism by the peripheral LVP is at least partly due to suppression of BAT thermogenesis. After bilateral sino-aortic deafferentation, however, the changes in these variables were greatly but not completely reduced except for the elevation of BP. LVP of 0.25 micrograms, more than sufficient to cause a significant elevation of BP when administered peripherally, had no effect on M and Tco1 when injected into the anterior hypothalamus. From these results, we conclude that the hypothermic effect of vasopressin administered peripherally is largely attributed to the baroreflexive suppression of nonshivering thermogenesis, and is not due to the action on the temperature regulatory centers. The slight but insignificant suppression of metabolism in the sinoaortic denervated rats following injection of LVP may be caused by a decreased blood flow to the thermogenic tissues.
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PMID:Baroreflexive suppression of heat production and fall in body temperature following peripheral administration of vasopressin in rats. 649 92

The effect of intranasal administration of 10 micrograms of 1-deamino-8-d-arginine vasopressin (DDAVP) and intravenous administration of 200 micrograms of N-glycyl-glycyl-glycyl-lysin-vasopressin (TGLVP) on urinary concentration (UK) and fractional excretion (FEK) of potassium was investigated in healthy subjects. For comparison the same parameters were followed under conditions of 36-h water-intake restriction. Once the maximally concentrated urine had been reached, the average value of UK after DDAVP administration was 108 +/- 45 mmol/l and after TGLVP administration 102 +/- 48 mmol/l. These values are significantly higher (p less than 0.001) than the average value of UK observed under conditions of water deprivation (58 +/- 22 mol/l). The average value of FEK after DDAVP administration was 14.8 +/- 6.3% and after TGLVP administration, 14.9 +/- 6.5%. These values are also significantly higher (p less than 0.001) than the average values of FEK observed under control conditions (9.3 +/- 5.5%) The effect of DDAVP on UK and FEK was related to the age of the investigated subjects. The most pronounced changes were observed in younger individuals. The influence of vasopressin analogs on UK and FEK could not be explained on the basis of changes in urinary osmolarity, sodium excretion, or fractional water excretion. The results obtained are compatible with the hypothesis that DDAVP and TGLVP increase the tubular secretion of potassium. The mechanism of action has to be elucidated by further research.
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PMID:The influence of a single dose of vasopressin analogs on human renal potassium excretion. 707 44

In order to investigate the central and peripheral circulatory effects of a vasoactive drug, lysin vasopressin (LVP), in the early postburn period, 18 piglets were submitted to an experimental study. Anaesthesia was performed by thiopentone sodium as i.v. infusion and mechanically controlled ventilation via endotracheal intubation. Burn injury was brought about by heated metal stamps applied to the back and sides of the animals causing a full thickness skin burn corresponding to 32-35% of the total body surface area. Cardiac output decreased significantly after burn and so did organ blood flow, measured with radioactively labelled microspheres, especially after 4 hours. LVP-infusion did not further decrease cardiac output after burn but decreased the blood flow to the skin, carcass and proximal gastrointestinal tract. The liver perfusion was increased, while the flow in the other organs was not different from that in burned pigs not given LVP. The therapeutical implications are discussed.
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PMID:The effects of lysine-vasopressin on hemodynamics during early post burn period in pigs. 715 7


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