Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01185 (
vasopressin
)
23,126
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The most widely known oxytocic drug that can be used for the induction of labor or post-partum is oxytocin. In 1954, the american biochemist Vincent du Vigneaud was the first to describe an octapeptide amide with the hormonal activity of oxytocin. One year later, he was able to synthesize this octapeptide amide. In the same year he received the Nobel prize for his work in the field of biochemistry. A reprint of his brilliant publication is reproduced [with kind permission of the editors of the J Am Chem Soc]. With slight changes in structure, du Vigneaud was able to synthesize not only oxytocin, but also
vasopressin
. In our paper, however, we will focus on oxytocin only, as it is this synthetic hormone that has gained considerable importance in obstetrics. It is used for prevention of
PPH
as well as for induction of labour.
...
PMID:History and use of oxytocics. 1113 19
