Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01185 (vasopressin)
23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This article briefly describes the recent progress and opinion on experimental pituitary tumors in various animals. 1) A high incidence of spontaneous pituitary tumor is known in Sprague-Dawley and Wistar rats. 2) Recent studies suggest that the pituitaries of estrogen-treated animals are not tumoral and only hyperplastic. 3) Salmon calcitonin injection for 6 months caused a higher incidence of pituitary hyperplasia or non-functioning adenoma. 4) Mice transgenic by hGRF shows GH-producing hyperplasia or adenoma in the pituitary. 5) Introduction of choleratoxin transgene into mice caused gigantism. 6) Transgenic mice, that develop ACTH-producing pituitary tumor, were generated by PyLT. 7) Mice transgenic for vasopressin-SV 40 hybrid oncogene develop tumors of the endocrine pancreas and the pituitary (as a model of MEN type II).
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PMID:[Recent progress in experimental pituitary tumors in various animals]. 825 25