Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01185 (
vasopressin
)
23,126
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We investigated the effects of the prolyl endopeptidase inhibitors 1-[1-(Benzyloxycarbonyl)-L-prolyl]prolinal (
Z-Pro-Prolinal
) and N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylaceta l (ZTTA) on delayed neuronal death induced by four-vessel-occlusion transient ischemia in rats. We also examined the effects of [pGlu4, Cyt6, ArgS]
vasopressin
(
vasopressin
-(4-9)) and thyrotropin-releasing hormone (TRH) on the delayed neuronal death. Furthermore, we investigated the role of
vasopressin
receptors in the effects of
vasopressin
and prolyl endopeptidase inhibitors.
Z-Pro-Prolinal
,
vasopressin
-(4-9) and TRH protected pyramidal cells in the CA1 subfield of the rat hippocampus from delayed neuronal death after 10-min ischemia. The effect of
vasopressin
-(4-9) was abolished by
vasopressin
receptor antagonists. The effect of
Z-Pro-Prolinal
was also abrogated by the antagonists. These results suggest that the neuroprotective effect of prolyl endopeptidase inhibitors is mediated by neuropeptides such as [Arg8]
vasopressin
and TRH, and indicate the involvement of
vasopressin
receptors in the neuroprotective effect of
vasopressin
-(4-9) and prolyl endopeptidase inhibitors.
...
PMID:Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats. 1039 93
