Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Conscious rats were given i. p. polyethylene glycol (PEG) or dextran injections to compare their efficacy in inducing moderate hypovolaemia. Dextran was found unsuitable, producing large variability in the plasma vasopressin (AVP) concentrations. Putative neurotransmitters involved in the AVP response to hypovolaemia and in basal release were examined using opioid, and beta-adrenoceptor and dopamine receptor-blocking agents. A dose of PEG was chosen to produce a decrease in blood volume of approx 14.5% giving plasma AVP concentrations of 19.0 +/- 4.6 pmol/l. Naloxone and phenoxybenzamine failed to influence AVP release under both hypovolaemic and basal conditions. Prazosin also failed to influence the AVP response. In contrast propranolol elevated the plasma AVP concentrations in both conditions. Haloperidol enhanced basal AVP release but did not influence release during hypovolaemia. Guanethidine pretreatment partially blocked the response to hypovolaemia, but did not affect basal plasma AVP. Thus it appears that aminergic pathways have an inhibitory influence on AVP release under hypovolaemic and basal conditions. However, endogenous opioids do not appear to contribute significantly to the hypovolaemic response.
 ...
PMID:Vasopressin release in response to hypovolaemia in the conscious rat and the effect of opioid and aminergic receptor antagonists. 168 65

Pig isolated renal arteries contract in response to addition of noradrenaline, 5-hydroxytryptamine, histamine, angiotensin II, vasopressin and carbachol, whereas cholecystokinin, adenosine, and inosine produce relaxation. Transmural stimulation of the tissue causes contraction of circular muscle in the arterial wall which produces apparent elongation of the vessel. The effects of transmural stimulation are partially blocked by prazosin and potentiated by propranolol, indicating that noradrenaline acts through both alpha- and beta-adrenoceptors. Guanethidine (10(-5) M) reduces the size of responses to transmural stimulation in the presence of both prazosin (10(-6) M) and propranolol (10(-7) M). Both saralasin (10(-7) M), and desensitization of angiotensin II receptors by prolonged contact with the peptide, produced a reduction in response to transmural stimulation, indicating that angiotensin II may be involved in neurotransmission. This effect was blocked by tetrodotoxin. Transmural stimulation produces relaxation of renal arteries in the presence of maximal doses of saralasin, prazosin, and propranolol, suggesting that a third unidentified substance is also released from autonomic nerves.
 ...
PMID:Responses of the pig isolated renal artery to transmural electrical stimulation and drugs. 400 89

Plasma vasopressin, arterial blood gas tensions, pH, arterial blood pressure, heart rate and respiration were monitored in conscious rats breathing room air or exposed to varying degrees of hypoxia. A similar series of observations was made in a group of anaesthetized rats and in rats treated with alpha- and beta-adrenergic and dopaminergic blocking agents. The effect of two opioid antagonists on the vasopressin response was also noted. Hypoxia produced an increase in circulating vasopressin concentrations in both conscious and anaesthetized rats. In the conscious animals the increase reached statistical significance when the animals were exposed to 12% oxygen in nitrogen, which produced a fall in arterial PaO2 of 44.7 +/- 5.0%. Guanethidine, phentolamine and propranolol all produced a significant fall in the basal concentrations of vasopressin, while guanethidine, phenoxybenzamine and propranolol blocked the increase seen on breathing 12% oxygen in nitrogen. Naloxone and levallorphan also reduced the vasopressin response to hypoxia. Thus it appears that aminergic pathways play a role in the maintenance of circulating concentrations of vasopressin and in the response to hypoxia. Endogenous opioids also appear to be involved in the hypoxic response.
 ...
PMID:Release of vasopressin in response to hypoxia and the effect of aminergic and opioid antagonists. 663 8