Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ca2+ is thought to play a role in the enhancement of water permeability of toad urinary bladder epithelial cells by antidiuretic hormone (ADH) or theophylline. This study examined the effects of ADH and theophylline on intracellular free Ca2+ ([Ca2+]i) and total cellular exchangeable Ca2+ in isolated toad bladder epithelial cells. ADH or theophylline enhanced water permeability maximally by 15-25 min after a 4-min lag. 45Ca2+ efflux, a probe for total cellular exchangeable (plasma membrane plus intracellular) Ca2+, was enhanced by ADH within 2 min and returned to control by 8 min. Chlortetracycline fluorescence, a probe for intracellular Ca2+ only, was not affected, suggesting that ADH released only plasma membrane-bound Ca2+. Theophylline enhanced 45Ca2+ efflux and decreased chlortetracycline fluorescence, suggesting release of Ca2+ from intracellular sources. Both agents decreased [Ca2+]i as assessed by quin-2 fluorescence with a time course similar to the enhancement in water permeability. The results suggest that the changes in membrane-bound Ca2+ and [Ca2+]i induced by ADH and theophylline may play a role in the enhanced permeability to water in response to these agents.
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PMID:ADH or theophylline-induced changes in intracellular free and membrane-bound calcium. 643 53

In thoracic-spinal-cord-transected rats, mean circulatory pressure (Pmc) was measured during brief circulatory arrest by inflating an indwelling balloon in the right atrium and total blood volume (VB) was measured with 51Cr. The Pmc-VB relationship was determined over the range +/- 30% VB by rapid blood infusion or withdrawal. An infusion of 1.5 microgram/kg per min of epinephrine for 20-40 minutes caused the total circulatory compliance (Ctc) to decrease 18%, the extrapolated unstressed circulatory volume (V'o) and VB to decrease 8.6 and 7.3 ml/kg, respectively, and PMC to increase 41% (2.6 mm Hg). Total circulatory capacity (circulatory volume at a PMC of 8 mm Hg) was decreased 13.7 ml/kg by epinephrine at the above infusion rate. When vasopressin (20 ng/kg per min) and epinephrine (0.3 microgram/kg per min) were infused together for 20-40 minutes, compared to a 0.3 microgram/kg per min infusion of epinephrine alone, the net effect of vasopressin was a 4.8 ml per kg decrease in VB and a 5.9 ml/kg decrease in total circulatory capacity, with insignificant decreases in CTC and V'o. The results indicate that in rats both epinephrine and vasopressin act to decrease blood volume via transcapillary fluid shifts, and that vasopressin has a relatively small overall venoconstricting action.
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PMID:Total circulatory capacity in the rat. Effects of epinephrine and vasopressin on compliance and unstressed volume. 727 62

Nephrogenic diabetes insipidus (NDI) is caused by the inability of renal collecting duct cells to respond to arginine vasopressin (AVP)/antidiuretic hormone (ADH). We present the case of a 7-year-old boy with a history of excretion of large amounts of dilute urine and polydipsia since infancy. The boy had several vomiting episodes with mild dehydration during the first 3 years of life. There was no evidence of headaches, dizziness or visual problems. He drinks between 2 and 3 L/day and has 24-hour diuresis of 2 liters, now. He has prepubertal appearance with appropriate weight [+0.85 standard deviation score (SDS)] and height (+0.15 SDS) for his age. His intelligence was also normal. The water deprivation test showed low urine osmolality after 8 hours of dehydration. After desmopressin administration, urine osmolality remained low. Serum osmolality was in the normal range for sex and age before and after desmopressin administration. This indicated a nephrogenic form of diabetes insipidus. Molecular analyses revealed a P286L [p.Pro(CCC)286Leu(CTC)] mutation in the AVPR2 gene, that was inherited from his mother. This patient is the first case with genetically confirmed X-linked inherited form of NDI in the Republic of Macedonia. Molecular analysis confirmed the clinical diagnosis and enabled genetic advice for this family.
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PMID:X-Linked Recessive form of Nephrogenic Diabetes Insipidus in a 7-Year-Old Boy. 2593 2