Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alterations in gastric physiology caused by selective embolization and vasopressin infusion of the left gastric artery were evaluated in 29 dogs. Gastric acidity was not significantly altered following Gelfoam embolization but decreased sharply with vasopressin infusion. These results suggest that the segmental occlusion caused by Gelfoam embolization permits significant collateral blood flow to the gastric mucosa, while the arteriolar and capillary constriction caused by vasopressin effectively decreases mucosal blood flow. These findings are consistent with the clincal observation that embolization is more effective in controlling bleeding ulcers, while vasopressin infusion is more effective for controlling hemorrhagic gastritis.
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PMID:Alterations in gastric physiology caused by selective embolization and vasopressin infusion of the left gastric artery. 108 10

1. Bovine neurophysin-II contains 1mol of tyrosine residue/10000g of protein. This residue could be readily nitrated with tetranitromethane. On hydrolysis and amino acid analysis 1mol of 3-nitrotyrosine was found/10000g of protein. Starchgel electrophoresis at pH8.5 showed that nitration had converted the native protein into a single, more acidic species. The increase in acidity was consistent with the observed fall in pK of the tyrosine hydroxyl from 9.2 in native neurophysin to 7.3 in the nitrated protein. Further, the absence of any intermediate species, even under conditions of minimum substitution, confirmed that the molecular weight of the monomer is 10000. 2. O-Acetylation of the tyrosine residue was carried out with N-acetylimidazole, in conjunction with the reversible blocking of amino groups by citraconylation. The degree of O-acetylation, determined spectroscopically, was 0.9mol of O-acetyltyrosine/10000g of protein. 3. The hormone-binding ability of modified protein was tested by equilibrium dialysis and was found to be unchanged by either nitration or O-acetylation of the tyrosine residue. 4. Interaction of neurophysin-II and [8-arginine]-vasopressin gave rise to a characteristic difference spectrum with a peak at 286.8nm and shoulder at 279.6nm. Part of this hyperchromicity is thought to result from entry of the tyrosine residue at position 2 in the hormone into the hydrophobic environment of the binding site. With nitrated neurophysin-II a second peak appeared at 436nm, showing that the tyrosine of the protein is also perturbed. The very large red shift (84nm) in this region suggests that the 3-nitrotyrosyl residue not only enters a more hydrophobic environment on protein-hormone interaction, but is caused to ionize more fully by the approach of some positively charged group.
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PMID:Studies on the chemical modification of the tyrosine residue in bovine neurophysin-II. 546 18

The experiments were performed on dogs with isolated pouches (according to Pavlov, Heidenhain and Gregory) to study the action of antidiuretic hormone (ADH) on gastric secretion produced by a food irritant (100 g of meat) and by administration of histamine and pentagastrin. ADH was shown to exert an inhibitory action on gastric secretion induced by food or humoral irritants in dogs with isolated pouches according to Pavlov and Heidenhain. In dogs with completely denervated isolated pouches, food irritant-induced gastric secretion was suppressed for 2 1/2--3 1/2 h. Then it exceeded the control level. During ADH administration the total acidity and the content of free hydrochloric acid noticeably decreased as compared to control. There was also a clear-cut tendency to a reduction in the concentration of common proteinases in gastric juice. Adrenoblockers abolished the inhibitor action of ADH on gastric secretion produced by food or humoral irritants, while the inhibitory action of fat was not reversed by phentolamine or obsidan. The data obtained indicate a different mechanism of the inhibitory effect of fat and ADH on gastric secretion.
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PMID:[Possible participation of the antidiuretic hormone in the inhibiting action of at on gastric secretion]. 740 31