Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 29 patients with severe hemorrhagic fever associated with the renal syndrome were studied for impact of extracorporeal hemodialysis on the activity of the renin-aldosterone system (RAS), plasma vasopressin and osmolality and the levels of the major osmotically active agents, as well as the circadian urine output and blood pressures. In patients with oliguria there was a significant activation of RAS, an increase in plasma vasopressin ad osmolality due to the increment of the urea in presence of hyponatremia. Hemodialysis led to a temporary normalization of plasma aldosterone and vasopressin levels and a decrease in blood pressure. No significant changes were documented in the activity of the plasma renin and circadian urinary output. A direct correlation was established between the plasma osmolality and the levels of vasopressin. In patients with polyuria developed in presence of hypernatremic hyperosmia plasma vasopressin elevated and aldosterone dropped.
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PMID:[The effect of hemodialysis on the vasopressin level and on the renin-aldosterone system in patients with hemorrhagic fever with renal syndrome]. 197 Sep 14

The aim of the study was a search of physiological approach to restoring osmotic homeostasis in rats with hypernatremia. Intraperitoneal administration of 1.8 ml/100 g BW 2.5% NaCl solution to Wistar rats induced hyperosmia (306 +/- 1 mOsm/kg H2O) and hypernatremia (150.3 +/- 0.3 mM in 60 min of experiment), increase in urinary sodium excretion (from 8 +/- 1 to 230 +/- 10 micromol/100 g BW for 2 h). Under these conditions enhancement of natriuresis up to 465 +/- 29 micromol/100 g BW and 667 +/- 24 micromol/100 g BW for 2 h was observed after injections of vasopressin analogue, deamino-vasotocin (dAVT, 0.05 microg/100 g BW), or loop diuretic, furosemide (1 mg/100 g BW), respectively. dAVT-induced natriuresis was accompanied by increase in solute-free water reabsorption; serum osmolality (301 +/- 1 mOsm/kg H2O) and sodium concentration (145.8 +/- 0.5 mM) were close to normal values by 60 min of experiment. Furosemide caused relatively greater excretion of water, than sodium; hypernatremia (150.2 +/- 0.4 mM) and hyperosmia (311 +/- 1 mOsm/kg H2O) persisted during 60 min of experiment. Thus, in rats with hypernatremia dAVT due to decrease in renal sodium reabsorption and increase in solute-free water reabsorption promotes recovery of serum osmolality and sodium concentration.
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PMID:[PHYSIOLOGICAL APPROACH TO RESTORING OSMOTIC HOMEOSTASIS IN RATS WITH HYPERNATREMIA]. 2659 Oct 53