Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to study structure-activity relationships as to Factor VIII release conscious dogs were injected with analogues of vasopressin. The peptides used were chemically modified either in the hexapeptide ring structure of the vasopressin molecule or in the C-terminal tripeptide or in both. The results showed that an intact C-terminal appears to be of importance for retaining Factor VIII releasing activity of the analogues, whereas at least some modifications of the ring structure are tolerated without loss of activity. Decreased activity was also observed when the disulphide bridge was substituted with a monocarba bond.
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PMID:Structure-activity relationships of vasopressin analogues on release of factor VIII in dogs. 171 19

The effect of leucine5-enkephalin (Leu-enkephalin) administered into the lateral (LV) or fourth (4V) cerebroventricle on angiotensin II (ANG II)-stimulated increase in blood pressure, plasma vasopressin concentration ([AVP]), and drinking behavior was determined in conscious rats. Leu-enkephalin (20, 50, or 100 micrograms) was injected into the LV (5 microliters) or 4V (2 microliters) less than or equal to 15 s before ANG II (50 or 500 ng, LV). LV and 4V administration of Leu-enkephalin (100 or 50 micrograms) significantly (P less than 0.05) delayed the drinking onset, decreased the number of animals drinking, and reduced the volume consumed (100 micrograms, 30 min) in response to ANG II (50 ng). ANG II-stimulated increases in plasma [AVP] and blood pressure were inhibited by 50 or 100 micrograms, respectively, of Leu-enkephalin administered into LV but not 4V. Decreased motor activity occurred after Leu-enkephalin (100 micrograms) administration into LV and 4V, whereas head shakes were more consistent after the former. Fast green dye administered into 4V did not reach anterior periaqueductal, third, or lateral cerebroventricular sites. Thus opioid peptide receptors inhibiting ANG II-stimulated drinking, vasopressin release, and pressor response are postulated to be in brain structures accessible from lateral or third cerebroventricles. Opiate receptors inhibitory to drinking are also reached from peri-4V sites.
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PMID:Cerebroventricular sites for enkephalin inhibition of the central actions of angiotensin. 634 May 33

Hypokinesia (decreased motor activity) induces significant morphological changes in the kidneys, but little is known about the effect of hypokinesia (HK) on the collecting duct nuclei of the kidney. The aim of this study was to measure the effect of prolonged HK on the nuclear size in the inner meduallary collecting ducts on the kidney of rats. Studies were done on one hundred ninety-two 13-week-old male rats (370 to 390 g) during 15 days pre HK period and 90 days HK period. Rats were equally divided into two groups: vivarium control rats (VCR) and hypokinetic rats (HKR). The HKR group kept in small individual cages. Nuclear size in renal collecting tubules, fluid excretion, sodium (Na) and potassium (K) in plasma and urine, plasma aldosterone (PA) and antidiuretic hormone (ADH) and body weight were measured. A significant (p < or = 0.01) increase in size of the collecting duct nuclei of the kidney, PA, plasma and urinary Na and K and fluid loss, and a significant (p < or = 0.01) decrease of body weight and plasma ADH observed in the HKR group when compared with the VCR. The measured parameters did not change significantly in the VCR group when compared with their baseline control values. It was concluded that prolonged HK induces a significant increase of the nuclear size in the inner meduallary collecting ducts of the kidney of hypokinetic rats when compared with the control rats.
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PMID:Measurements of nuclear size in collecting tubules of the kidney of rats during prolonged hypokinesia and ambulatory conditions. 1223 Feb 65