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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of peripheral injection of various doses of lysine-vasopressin (LVP), administered 30 min before a 5-min session in a hole-board apparatus, were compared as a function of food restriction. Comparison of performance for various indices of general activity clearly showed that the food-restricted rats were more active and exhibited less photophobia than normally fed ones. The differences between the two groups were maintained in a second session 24 hours later. There was no sign of behavioral habituation to the apparatus among restricted animals. Different doses (0.2, 1, 2 micrograms of LVP) affected food-restricted animals differently from the rats fed ad lib. Only the highest dose reduced activity in both groups. A posttest injection of the smallest dose (0.2 micrograms) had an opposite effect on the activity in the hole-board, measured 24 hours after the injection. A second experiment showed that plasma and adrenal corticosterone were higher in deprived rats. The administration of 0.2 micrograms of LVP was followed by an increase in corticosterone. In food-restricted rats this increase was bigger and was still observed 24 hours after the injection. There is an interaction between feeding conditions and LVP injections which affects both the internal hormonal state and spontaneous reactivity to environment. These findings are of relevance to the effect of vasopressin on behavior.
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PMID:Food-restriction interacts with vasopressin modulation of activity. 194 19

The effects of subcutaneous administration of vasopressin on spontaneous black-white choice were investigated to determine whether they could account for modifications of performances during learning. First, pretrial injections of 0.2 microgram of lysine-vasopressin (LVP) were given to rats fed ad lib submitted after the last injection to ten consecutive choices in the T-maze. Rats received one or five injections and were tested after either 30 minutes or 24 hours. Treatment with LVP reduced natural photophobia and modified the activity. A more striking effect was observed after one injection and with an injection-test interval of 30 min. Second, the influence of repeated injections of LVP on free choices was studied in food-motivated rats. The effect of repeated injections was marked, suggesting greater sensitivity to treatment in such rats. Third, we compared the action of posttrial administration of the peptide on the behavior of food-restricted rats submitted to appetitive learning in the T-maze, or to free choices. The treatment slightly disturbed the learning of the white arm and altered the preference for black in free choices condition. The two actions were different, showing that the effect on spontaneous behavior cannot account for the effect on learning.
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PMID:Effects of vasopressin on spontaneous black-white choices in a T-maze. 234 69