Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The polymerase chain reaction (PCR) has been combined with hybrid somatic cell technology to extend the bovine physical map. Eight bovine loci--glycoprotein hormone alpha (CGA), coagulation factor X (F10), chromogranin A (CHGA), low-density lipoprotein receptor (LDLR), human prochymosin pseudogene (CYM), oxytocin (OXT), arginine-vasopressin (ARVP), and cytochrome oxidase c subunit IV pseudogene (COXP)--were assigned to bovine syntenic groups with this approach. CGA was assigned to bovine syntenic group U2, F10 to U27, CHGA to U4 [bovine Chromosome (Chr) 21], LDLR to U22, CYM to U6, OXT and ARVP to U11, and COXP to U3 (bovine Chr 5). Seven of these genes, CGA, F10, CHGA, LDLR, OXT, ARVP, and CYM, further delineate regions of chromosomal conservation on human Chrs 6, 13, 14, 19, 20, 20, and 1, respectively. CHGA, OXT, and ARVP are unmapped in the mouse. Comparative mapping predicts the mouse CHGA will map to Chr 12, and mouse OXT and ARVP will map to mouse Chr 2. Furthermore, human CYM is predicted to be sublocalized to 1p32-q21. The primers developed for these eight loci will be useful for the development of hybrid somatic cell panels in the future as well as establishing a collection of bovine expressed sequence tags.
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PMID:Assignment of eight loci to bovine syntenic groups by use of PCR: extension of a comparative gene map. 161 14

In a 59-year-old woman suffering from the syndrome of inappropriate antidiuretic hormone secretion, a small cell carcinoma of the uterine cervix was detected. The tumor was immunoreactive for antidiuretic hormone as well as for neuron specific enolase, chromogranin A, and Leu-7, but not vimentin. Electron microscopic examination of the tumor revealed neurosecretory granules. To our knowledge, this is only the second report of the syndrome of inappropriate antidiuretic hormone secretion with small cell carcinoma of the uterine cervix and the first one confirmed immunohistopathologically.
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PMID:Small cell carcinoma of the uterine cervix with syndrome of inappropriate antidiuretic hormone secretion. 872 79

Chromogranin A (CGA) is a calcium-binding glycoprotein thought to be the precursor of several peptides with defined biological activity. Chromogranin A has been localized in most endocrine cells and many neurons in the CNS. Here we studied its expression in neurons of the hypothalamo-neurohypophysial system, which secrete the neurohormones oxytocin and vasopressin. Light and electron microscopic immunocytochemistry and immunoblot analysis with antibodies specific for CGA revealed high levels of chromogranin A immunoreactivity throughout the hypothalamo-neurohypophysial system. In the supraoptic and paraventricular nuclei, it was characterized by intracytoplasmic labelling of magnocellular somata and processes and of certain astrocytes. Extensive labelling of fibres and dilatations characterized the internal layer of the median eminence and the neurohypophysis, transit and terminal site of the neurosecretory axons, respectively. Tanycyte-like cells in the median eminence also displayed reaction. Simultaneous immunofluorescence showed that oxytocinergic and vaso-pressinergic neurons contain chromogranin A. Electron microscopy revealed that chromogranin A immunoreactivity (visualized by pre-embedding immunoperoxidase or silver-enhanced colloidal gold techniques) was associated with neuro-secretory granules in hypothalamo-neurohypophysial system neurons. In astrocytes and pituicytes, it was seen over the cytoplasm and glial filaments. In tissue from colchicine-treated or immobilization-stressed rats, it was clear that chromogranin A immunoreactivity in the hypothalamus was confined to the hypothalamo-neurohypophysial system. In rats in which neurohypophysial secretion was strongly stimulated by dehydration, immunocytochemistry showed that hypothalamo-neurohypophysial system immunoreactivity significantly increased in the magnocellular nuclei but decreased in the neurohypophysis. On the other hand, chromogranin A distribution was not markedly affected by stress or lactation. These observations demonstrate that chromogranin A is present in neurons and, to a lesser degree, glial cells of the hypothalamo-neurohypophysial system and that its expression is closely related to that of the neurohypophysial peptides.
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PMID:Immunocytochemical localization of chromogranin A in the normal and stimulated hypothalamo-neurohypophysial system of the rat. 886 41

Although the production of pituitary hormones by adenohypophysial tumors has been studied extensively, an examination of the immunophenotype of pituitary adenomas using a broad spectrum of antibodies has not been previously investigated. We studied 23 pituitary adenomas using a large panel of antibodies to determine if these tumors exhibited a common immunophenotype. Various neuroendocrine markers, synaptophysin, neuron-specific enolase (NSE), and the intermediate filament protein, low-mol-wt keratin were expressed in most examples. There was, however, differential expression of chromogranin A in that few prolactin (PRL) and adenocorticotrophic hormone (ACTH) adenomas stained positively, whereas all other adenoma subtypes were reactive. The ACTH adenomas had a unique profile with positive staining for galanin, neurophysiri, vasopressin, and ubiquitin. These results indicate that (1) pituitary adenomas do not express a single "generic" immunophenotype; (2) synaptophysin is the most reliable and best broad spectrum marker for pituitary adenomas; (3) the neuroendocrine granule marker chromogranin A is useful in the identification of null cell adenoma, a tumor that usually does not stain for anterior pituitary tumors; and (4) among pituitary tumors, ACTH adenomas have a unique immunoprofile.
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PMID:The Immunophenotype of Pituitary Adenomas. 1211 42