Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experimental results showed that the ECG changes (elevation of T wave, a shift of the S-T segment and disturbances of the atrio-ventricular conduction) under the effect of vasopressin occurred in rats aged 24-26 months after lower doses of vasopressin than in the animals aged 10-12 months. With the administration of the same doses coronary insufficiency was more pronounced in the old animals (more frequent disturbances of the atrio-ventricular conduction, grade II or III, and greater derangement of general hemodynamics).
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PMID:E1Age and the development of coronary insufficiency under the influence of vasopressin. 95 93

With aging the content of the blood vasopressin increases. In old animals smaller doses of vasopressin induce coronary insufficiency (rise of T wave, shift of S-T segment, disorders of the atrio-ventricular conductivity). On continuous administration of vasopressin (during a month), arterial hypertension appears only in old animals due to increase in cardiac output, stroke volume at unchanged cardiac rhythm, and to some decrease in the total peripheral resistance.
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PMID:[Vasopressin concentration in the blood and sensitivity of the cardiovascular system to it during aging]. 127 35

Adult and old rats and rabbits revealed age-related changes of the reactivity of isolated vessels to catecholamines, vasopressin and acetylcholine. Changes that occurred in the sensitivity of various vascular areas during ageing were irregular. The increase in sensitivity of coronary vessels to vasopressin and rise of concentration of hormones in the blood promoted the development of coronary insufficiency. Stress, catecholamines sharply increased the sensitivity of coronary vessels of old rats to vasopressin. In adult and old rabbits the dyslipoproteinemia altered the sensitivity of aortal smooth muscles to epinephrine, while in old animals it enhanced the contractile effect. The shifts in vascular endothelium were shown to play certain role in the changes of vascular reactivity during ageing. The vasopressin-induced rise of cGMP in the vascular smooth muscles was more obvious in old vs. adult rats.
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PMID:[The changes in vascular reactivity during aging]. 166 13

Ion transport properties and some components of lipid structure in myocardial sarcolemma were studied under conditions of short-term acute ischemia simulated in rabbits by means of intravenous administration of vasopressin at a dose of 0.2 U/kg. The acute coronary insufficiency was accompanied by distinct alterations in the parameters specific for calcium metabolism and transport: activity of Na+, K+-ATPase and the rate of Na+Ca2+ turnover were decreased, while 45Ca-binding ability and content of Ca2+ were increased in the myocardial sarcolemma. Alterations in lipid structure, phospholipid composition of membranes and accumulation of free fatty acids appear to be responsible for the phenomenon observed. The increased rate of calcium ions transport found may occur due to alterations in the sarcolemma structure.
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PMID:[Ion-transport system and various components of sarcolemma structure during acute myocardial ischemia]. 357 53

After short-term coronary insufficiency caused by administration of vasopressin, content of malonic dialdehyde and diene conjugates was increased in mitochondria and sarcoplasmic reticulum of rabbit myocardium. The alterations observed were prevented by means of preadministration of antioxidant belonging to 1,4-dihydropyridines.
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PMID:[Lipid peroxidation in myocardial mitochondria and the sarcoplasmic reticulum in short-term impairment of coronary circulation]. 398 65

Ergometrine usually depresses the S-T segment as in coronary insufficiency, when injected intravenously in rabbits with experimental coronary atherosclerosis and in patients with effort angina, but not in normal animals and man. To explain this difference, we carried out Langendorff perfusion studies in 32 normal and 29 atherosclerotic isolated rabbit hearts. Preliminary tests with ergometrine were done to ensure that advanced coronary atherosclerosis had developed in the rabbits fed a cholesterol diet; pathological examination of the heart after perfusion confirmed the result of the final test with ergometrine. Before drugs were perfused, the basal rate of coronary flow was greater, the heart rate was slower and the contractile amplitude was smaller in the atherosclerotic than in the normal hearts; nitroglycerin markedly increased flow in both normal and atherosclerotic groups. Ergometrine consistently caused a reduction in contractile amplitude with negligible changes in heart rate in both normal and atherosclerotic hearts. On coronary flow, however, the effects of ergometrine differed significantly in these groups; in doses of between 0.2 and 0.4 mg., the average decrease in flow was 8% in normal and 22% in atherosclerotic hearts. The effect was more variable in normal hearts and an increase in flow sometimes occurred. The difference in the response of normal and atherosclerotic hearts was particularly striking when ergometrine was given during recovery from a reduction of coronary flow which had been induced by vasopressin. Ergometrine then uniformly increased flow in the normal, but usually had the opposite effect in the atherosclerotic heart. In normal and atherosclerotic hearts, cardiac effects of vasopressin were similar. Tachyphylaxis to vasopressin, but not to ergometrine, was observed.
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PMID:Effects of ergometrine (ergonovine) on the isolated atherosclerotic heart of the cholsterol-fed rabbit. 1440 56