Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01185 (vasopressin)
 23,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 79-year-old man hospitalized for treatment of a major depressive episode was found to be hyponatremic, and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was diagnosed. The SIADH had not been present on past medical evaluations and appeared to have developed during the course of the psychiatric illness. Other causes of SIADH were excluded. The SIADH showed very little response to the standard medical treatment of fluid restriction and intravenous normal saline. It improved dramatically during the course of 7 ECT sessions, paralleling the improvement in the patient's mood. It is suggested that ECT may be an effective treatment for SIADH, possibly exerting its effect on a specific hypothalamic dysfunction.
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PMID:ECT as a possible treatment for SIADH: case report. 705 8

Reliable observation of ECT-induced hormone release requires that other processes that affect hormone levels remain constant and not obscure it. This article reviews principles and pitfalls in making such observations. Clinical applicability and limitations of measurements of prolactin, cortisol, oxytocin, vasopressin, and other hormones are described. Applications include elucidation of ECT physiology and seizure quality, comparison of ECT techniques, and description of illness severity. Accounting for each of these different effects can be needed to characterize any of them. An important but unrealized application of neuroendocrine measurement is prediction of the stability of individual ECT response.
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PMID:Neuroendocrine effects of electroconvulsive therapy (ECT). 923 Jun 41